A phase II study of vorinostat (MK-0683) in patients with polycythaemia vera and essential thrombocythaemia

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A phase II study of vorinostat (MK-0683) in patients with polycythaemia vera and essential thrombocythaemia

Andersen, Christen L. (author): Dept Haematol, Roskilde Hosp, Roskilde, Denmark.; Dept Haematol, Copenhagen Univ Hosp, Rigshosp, Copenhagen, Denmark

McMullin, Mary F. (author): Dept Haematol, Queens Univ Belfast, Antrim, North Ireland

Ejerblad, Elisabeth (author): Uppsala universitet,Hematologi,Dept Haematol, Univ Uppsala Hosp, Uppsala, Sweden

Zweegman, Sonja (author): Dept Haematol, Vrije Univ Amsterdam Med Ctr, Amsterdam, Netherlands

Harrison, Claire (author): Dept Haematol, Guys & St Thomas Hosp, London, England; NHS Foundation Trust, London, England

Fernandes, Savio (author)

Bareford, David (author): Dept Haematol, Russells Hall Hosp, Dudley, England

Knapper, Steven (author): Dept Haematol, Cardiff Univ, Cardiff, S Glam, UK

Samuelsson, Jan (author): Karolinska Institutet

Loefvenberg, Eva (author): Haematol Ctr, Karolinska Univ Hosp, Stockholm, Sweden

Linder, Olle (author)

Andreasson, Bjorn (author): Dept Haematol, NU Hosp Org, Uddevalla Hosp, Uddevalla, Sweden

Ahlstrand, Erik (author): Region Örebro län

Jensen, Morten K. (author): Dept Haematol, Herlev Hosp, Herlev, Denmark

Bjerrum, Ole W. (author)

Vestergaard, Hanne (author): Dept Haematol, Odense Univ Hosp, Odense, Denmark

Larsen, Herdis (author): Dept Internal Med, Dept Haematol, Viborg Hosp, Viborg, Denmark

Klausen, Tobias W. (author)

Mourits-Andersen, Torben (author): Dept Haematol, Esbjerg Cent Hosp, Esbjerg, Denmark

Hasselbalch, Hans C. (author): Dept Haematol, Roskilde Hosp, Roskilde, Denmark

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Dept Haematol, Roskilde Hosp, Roskilde, Denmark; Dept Haematol, Copenhagen Univ Hosp, Rigshosp, Copenhagen, Denmark Dept Haematol, Queens Univ Belfast, Antrim, North Ireland (creator_code:org_t)

2013-06-11
2013
English.
In: British Journal of Haematology. - : Wiley. - 0007-1048 .- 1365-2141. ; 162:4, s. 498-508

Related links:: https://urn.kb.se/re...; show more...; https://doi.org/10.1...; https://urn.kb.se/re...; http://kipublication...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Inhibition of histone deacetylases may be an important target in patients with myeloproliferative neoplasms. This investigator-initiated, non-randomized, open-label phase II multi-centre study included 63 patients (19 essential thrombocythaemia, 44 polycythaemia vera) from 15 centres. The primary objective was to evaluate if vorinostat was followed by a decline in clonal myeloproliferation as defined by European Leukaemia Net. Thirty patients (48%) completed the intervention period (24 weeks of therapy). An intention-to-treat response rate of 35% was identified. Pruritus was resolved [19% to 0% (P=0.06)] and the prevalence of splenomegaly was lowered from 50% to 27% (P=0.03). Sixty-five per cent of the patients experienced a decrease in JAK2 V617F allele burden (P=0.006). Thirty-three patients (52% of patients) discontinued study drug before end of intervention due to adverse events (28 patients) or lack of response (5 patients). In conclusion, vorinostat showed effectiveness by normalizing elevated leucocyte and platelet counts, resolving pruritus and significantly reducing splenomegaly. However, vorinostat was associated with significant side effects resulting in a high discontinuation rate. A lower dose of vorinostat in combination with conventional and/or novel targeted therapies may be warranted in future studies.

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Hematology

Articles in the publication: British Journal ...

By the university: Uppsala University; Örebro University; Karolinska Institutet

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A phase II study of vorinostat (MK-0683) in patients with polycythaemia vera and essential thrombocythaemia

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