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CYP2D6 Genotype and...
CYP2D6 Genotype and Adjuvant Tamoxifen : Meta-Analysis of Heterogeneous Study Populations
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- Province, M. A. (author)
- Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis MO, USA
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- Goetz, M. P. (author)
- Department of Oncology and Pharmacology, Mayo Clinic, Rochester MN, USA
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- Brauch, H. (author)
- Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany; Tübingen University, Tübingen, Germany
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- Flockhare, D. A. (author)
- Division of Clinical Pharmacology, School of Medicine, Indiana University, Bloomington IN, USA
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- Hebert, J. M. (author)
- Department of Genetics, School of Medicine, Stanford University, Stanford CA, USA
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- Whaley, R. (author)
- Department of Genetics, School of Medicine, Stanford University, Stanford CA, USA
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- Suman, V. J. (author)
- Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester MO, USA
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- Schroth, W. (author)
- Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany; Tübingen University, Tübingen, Germany
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- Winter, S. (author)
- Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology and University, Tuebingen, Germany
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- Zembutsu, H. (author)
- Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
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- Mushiroda, T. (author)
- Laboratory for Pharmacogenetics, RIKEN Center for Genomic Medicine, Yokohama, Japan
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- Newman, W. G. (author)
- Centre for Genetic Medicine, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK; Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK
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- Lee, M-TM. (author)
- Laboratory for International Alliance, RIKEN Center for Genomic Medicine, Yokohama, Japan
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- Ambrosone, C. B. (author)
- Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo NY, USA
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- Beckmann, M. W. (author)
- Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany
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- Choi, J-Y (author)
- Department of Biomedical Science, Graduate School, Seoul National University, Seoul, Korea
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- Dieudonne, A-S (author)
- Department of Oncology, Catholic University Leuven, Leuven, Belgium
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- Fasching, P. A. (author)
- Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany; Division of Hematology/Oncology, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles CA, USA
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- Ferraldeschi, R. (author)
- Centre for Genetic Medicine, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK; Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK
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- Gong, L. (author)
- Department of Genetics, School of Medicine, Stanford University, Stanford CA, USA
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- Haschke-Becher, E. (author)
- University Institute of Medical and Chemical Laboratory Diagnostics, Paracelsus Private Medical University, Salzburg, Austria
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- Howel, A. (author)
- The Christie NHS Foundation Trust, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK
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- Jordan, L. B. (author)
- Department of Pathology, Ninewells Hospital and Medical School, Dundee, UK
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- Hamann, U. (author)
- Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum, Heidelberg, Germany
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- Kiyotani, K. (author)
- Laboratory for Pharmacogenetics, RIKEN Center for Genomic Medicine, Yokohama, Japan
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- Krippl, P. (author)
- Medical University Graz, Graz, Austria
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- Lambrechts, D. (author)
- Vesalius Research Center, VIB and Laboratory of Translational Genetics, Department of Oncology, Catholic University Leuven, Leuven, Belgium
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- Latif, A. (author)
- Centre for Genetic Medicine, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK; Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK
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- Langsenlehner, U. (author)
- Medical University Graz, Graz, Austria
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- Lorizio, W. (author)
- Division of General Internal Medicine, Department of Medicine and Clinical Pharmacology and Experimental Therapeutics, and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco CA, USA
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- Neven, P. (author)
- Department of Gynecology and Obstetrics, University Hospitals Leuven, Leuven, Belgium
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- Nguyen, A. T. (author)
- Division of Clinical Pharmacology, School of Medicine, Indiana University, Bloomington IN, USA
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- Park, B-W. (author)
- Department of Surgery, Yonsei University Health System, Seoul, Korea
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- Purdie, C. A. (author)
- Department of Pathology, Ninewells Hospital and Medical School, Dundee, UK
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- Quinlan, P. (author)
- Dundee Cancer Centre, Dundee, UK
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- Renner, W. (author)
- Medical University Graz, Graz, Austria
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- Schmidt, M. (author)
- Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany; University Tübingen, Tübingen, Germany; Department of Gynecology and Obstetrics, University of Mainz, Mainz, Germany
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- Schwab, M. (author)
- Department of Clinical Pharmacology and Toxicology, University Hospital Tuebingen, Tuebingen, Germany
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- Shin, J-G (author)
- Department of Pharmacology and Pharmacogenomics Research Center, Inje University College of Medicine, Busan, Korea; Department of Clinical Pharmacology, Inje University Busan Paik Hospital, Busan, Korea
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- Stingl, J. C. (author)
- Division of Research, Federal Institute for Drugs and Medical Devices, University of Bonn Medical Faculty, Bonn, Germany
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- Wegman, Pia, 1964- (author)
- Örebro universitet,Hälsoakademin
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- Wingren, Sten, 1950- (author)
- Örebro universitet,Institutionen för läkarutbildning
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- Wu, A. H. B. (author)
- Department of Laboratory Medicine, University of California, San Francisco CA, USA
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- Ziv, E. (author)
- Division of General Internal Medicine, Department of Medicine and Clinical Pharmacology and Experimental Therapeutics, University of California, San Francisco CA, USA; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco CA, USA
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- Zirpoli, G. (author)
- Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo NY, USA
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- Thompson, A. M. (author)
- Dundee Cancer Centre, Dundee, UK
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- Jordan, V. C. (author)
- Department of Oncology, Georgetown University, Washington DC, USA
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- Nakamura, Y. (author)
- Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
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- Altman, R. B. (author)
- Department of Genetics, School of Medicine, Stanford University, Stanford CA, USA; Department of Bioengineering, Stanford University, Stanford CA, USA
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- Ames, M. M. (author)
- Department of Pharmacology, Mayo Clinic, Rochester MN, USA
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- Klein, T. E. (author)
- Department of Genetics, School of Medicine, Stanford University, Stanford CA, USA
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Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis MO, USA Department of Oncology and Pharmacology, Mayo Clinic, Rochester MN, USA (creator_code:org_t)
- 2013-09-23
- 2014
- English.
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In: Clinical Pharmacology and Therapeutics. - New York, USA : Nature Publishing Group. - 0009-9236 .- 1532-6535. ; 95:2, s. 216-227
- Related links:
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Abstract
Subject headings
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- The International Tamoxifen Pharmacogenomics Consortium was established to address the controversy regarding cytochrome P450 2D6 (CYP2D6) status and clinical outcomes in tamoxifen therapy. We performed a meta-analysis on data from 4,973 tamoxifen-treated patients (12 globally distributed sites). Using strict eligibility requirements (postmenopausal women with estrogen receptor-positive breast cancer, receiving 20 mg/day tamoxifen for 5 years, criterion 1), CYP2D6 poor metabolizer status was associated with poorer invasive disease-free survival (IDFS: hazard ratio = 1.25; 95% confidence interval = 1.06, 1.47; P = 0.009). However, CYP2D6 status was not statistically significant when tamoxifen duration, menopausal status, and annual follow-up were not specified (criterion 2, n = 2,443; P = 0.25) or when no exclusions were applied (criterion 3, n = 4,935; P = 0.38). Although CYP2D6 is a strong predictor of IDFS using strict inclusion criteria, because the results are not robust to inclusion criteria (these were not defined a priori), prospective studies are necessary to fully establish the value of CYP2D6 genotyping in tamoxifen therapy.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Keyword
- Medicine
- Medicin
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Province, M. A.
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Goetz, M. P.
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Brauch, H.
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Flockhare, D. A.
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Hebert, J. M.
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Whaley, R.
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show more...
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Suman, V. J.
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Schroth, W.
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Winter, S.
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Zembutsu, H.
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Mushiroda, T.
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Newman, W. G.
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Lee, M-TM.
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Ambrosone, C. B.
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Beckmann, M. W.
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Choi, J-Y
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Dieudonne, A-S
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Fasching, P. A.
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Ferraldeschi, R.
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Gong, L.
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Haschke-Becher, ...
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Howel, A.
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Jordan, L. B.
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Hamann, U.
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Kiyotani, K.
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Krippl, P.
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Lambrechts, D.
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Latif, A.
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Langsenlehner, U ...
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Lorizio, W.
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Neven, P.
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Nguyen, A. T.
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Park, B-W.
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Purdie, C. A.
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Quinlan, P.
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Renner, W.
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Schmidt, M.
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Schwab, M.
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Shin, J-G
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Stingl, J. C.
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Wegman, Pia, 196 ...
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Wingren, Sten, 1 ...
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Wu, A. H. B.
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Ziv, E.
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Zirpoli, G.
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Thompson, A. M.
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Jordan, V. C.
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Nakamura, Y.
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Altman, R. B.
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Ames, M. M.
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Klein, T. E.
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Örebro University