WFRF:(Louhio H)
Sökning: WFRF:(Louhio H) > (2006) > Kit ligand and c-Ki...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02966naa a2200361 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:1946186 | |
| 003 | SwePub | |
| 008 | 240701s2006 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:19461862 URI |
| 024 | 7 | a https://doi.org/10.1530/rep.1.008682 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Carlsson, IB4 aut |
| 245 | 1 0 | a Kit ligand and c-Kit are expressed during early human ovarian follicular development and their interaction is required for the survival of follicles in long-term culture |
| 264 | 1 | b Bioscientifica,c 2006 |
| 520 | a The receptor tyrosine c-Kit and its cognate ligand, c-Kit ligand (KL, stem cell factor, SCF), are involved in ovarian follicular development in several animal species. We studied the expression of KL and c-Kit usingin situhybridization and immunohistochemistry in donated human ovarian cortical tissue. The KL transcripts were expressed in granulosa cells of primary follicles, whereas the expression of c-Kit was confined to the oocyte and granulosa cells in primary and secondary follicles. We employed an ovarian organ culture using firstly serum-containing and then serum-free medium to study the effects of KL and an anti-c-Kit antibody, ACK2, on the development and survival of ovarian folliclesin vitro. Culture of ovarian cortical slices for 7 days resulted in a 37% increase in the number of primary follicles and a 6% increase in secondary follicles. The proportion of viable follicles decreased in all cultures. The addition of KL (1, 10 and 100 ng/ml) into the culture media did not affect the developmental stages of the follicles or the proportion of atretic follicles. Inclusion of ACK2 (800 ng/ml) in the culture medium significantly increased the proportion of atretic follicles on days 7 (49 vs 28% in control cultures) and 14 (62 vs 38%) of culture. In conclusion, c-Kit and KL are expressed in human ovaries during follicular development. Blocking the c-Kit receptor induces follicular atresia. The KL/c-Kit signaling system is likely to control the survival of human ovarian follicles during early follicular development. | |
| 700 | 1 | a Laitinen, MPE4 aut |
| 700 | 1 | a Scott, JE4 aut |
| 700 | 1 | a Louhio, H4 aut |
| 700 | 1 | a Velentzis, L4 aut |
| 700 | 1 | a Tuuri, T4 aut |
| 700 | 1 | a Aaltonen, J4 aut |
| 700 | 1 | a Ritvos, O4 aut |
| 700 | 1 | a Winston, RML4 aut |
| 700 | 1 | a Hovatta, Ou Karolinska Institutet4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t Reproduction (Cambridge, England)d : Bioscientificag 131:4, s. 641-649q 131:4<641-649x 1470-1626x 1741-7899 |
| 856 | 4 | u https://rep.bioscientifica.com/downloadpdf/journals/rep/131/4/1310641.pdf |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:1946186 |
| 856 | 4 8 | u https://doi.org/10.1530/rep.1.00868 |
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