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FältnamnIndikatorerMetadata
00011657naa a2200853 4500
001oai:DiVA.org:oru-105529
003SwePub
008230417s2023 | |||||||||||000 ||eng|
009oai:slubar.slu.se:121998
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-1055292 URI
0247 a https://doi.org/10.1126/science.abo50442 DOI
0247 a https://res.slu.se/id/publ/1219982 URI
040 a (SwePub)orud (SwePub)slu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Thienel, Manuelau Department of Cardiology, University Hospital, LMU Munich, 81377 Munich, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 80802 Munich, Germany4 aut
2451 0a Immobility-associated thromboprotection is conserved across mammalian species from bear to human
264 1b American Association for the Advancement of Science (AAAS),c 2023
338 a print2 rdacarrier
500 a Funding agencies:German Research Foundation (DFG) PE2704/2-1 PE2704/3-1DZHK (German Center for Cardiovascular Research) 80JSC018P0078 80JSC019P0010 100378833 806 32 006LMU Munich's Clinician scientist program in vascular medicine (PRIME)LMU Munich's institutional Forderprogramm fur Forschung und Lehre (FuFoLe)European Research Council (ERC) IFF 2020-26Helmholtz AssociationGerman Aerospace Centre (DLR)National Aeronautics & Space Administration (NASA)Faculty of Health at Witten/Herdecke University, GermanyBritish Heart Foundation FS/17/31/32848 SFB 1123Norwegian Environment Agency TRR267LMU Munich's Institutional Strategy LMU excellent
520 a Venous thromboembolism (VTE) comprising deep venous thrombosis and pulmonary embolism is a major cause of morbidity and mortality. Short-term immobility-related conditions are a major risk factor for the development of VTE. Paradoxically, long-term immobilized free-ranging hibernating brown bears and paralyzed spinal cord injury (SCI) patients are protected from VTE. We aimed to identify mechanisms of immobility-associated VTE protection in a cross-species approach. Mass spectrometry-based proteomics revealed an antithrombotic signature in platelets of hibernating brown bears with heat shock protein 47 (HSP47) as the most substantially reduced protein. HSP47 down-regulation or ablation attenuated immune cell activation and neutrophil extracellular trap formation, contributing to thromboprotection in bears, SCI patients, and mice. This cross-species conserved platelet signature may give rise to antithrombotic therapeutics and prognostic markers beyond immobility-associated VTE.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
650 7a NATURVETENSKAPx Biologix Zoologi0 (SwePub)106082 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Zoology0 (SwePub)106082 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng
7001 a Müller-Reif, Johannes B.u Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany; Omicera Diagnostics, 82152 Martinsried, Germany4 aut
7001 a Zhang, Zheu Department of Cardiology, University Hospital, LMU Munich, 81377 Munich, Germany4 aut
7001 a Ehreiser, Vincentu Department of Cardiology, University Hospital, LMU Munich, 81377 Munich, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 80802 Munich, Germany4 aut
7001 a Huth, Judithu Department of Cardiology, University Hospital, LMU Munich, 81377 Munich, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 80802 Munich, Germany4 aut
7001 a Shchurovska, Khrystynau Department of Cardiology, University Hospital, LMU Munich, 81377 Munich, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 80802 Munich, Germany4 aut
7001 a Kilani, Badru Department of Cardiology, University Hospital, LMU Munich, 81377 Munich, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 80802 Munich, Germany4 aut
7001 a Schweizer, Lisau Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany4 aut
7001 a Geyer, Philipp E.u Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany; Omicera Diagnostics, 82152 Martinsried, Germany4 aut
7001 a Zwiebel, Maximilianu Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany4 aut
7001 a Novotny, Juliau Department of Cardiology, University Hospital, LMU Munich, 81377 Munich, Germany4 aut
7001 a Lüsebrink, Enzou Department of Cardiology, University Hospital, LMU Munich, 81377 Munich, Germany4 aut
7001 a Little, Gemmau Institute for Cardiovascular and Metabolic Research, School of Biological Sciences, Health and Life Sciences Building, University of Reading, RG6 6UR, UK4 aut
7001 a Orban, Martinu Department of Cardiology, University Hospital, LMU Munich, 81377 Munich, Germany4 aut
7001 a Nicolai, Leou Department of Cardiology, University Hospital, LMU Munich, 81377 Munich, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 80802 Munich, Germany4 aut
7001 a El Nemr, Shazau Department of Cardiology, University Hospital, LMU Munich, 81377 Munich, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 80802 Munich, Germany4 aut
7001 a Titova, Annau Department of Cardiology, University Hospital, LMU Munich, 81377 Munich, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 80802 Munich, Germany4 aut
7001 a Spannagl, Michaelu Anesthesiology and Transfusion Medicine, Cell Therapeutics and Hemostaseology, Ludwig-Maximilians-University Munich, 80336 Munich, Germany4 aut
7001 a Kindberg, Jonasu Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för vilt, fisk och miljö,Department of Wildlife, Fish and Environmental Studies,Norwegian Institute Nature Research4 aut0 (Swepub:slu)48411
7001 a Evans, Alina L.u Department of Forestry and Wildlife Management, Faculty of Applied Ecology and Agricultural Sciences, Inland Norway University of Applied Sciences, 2480 Koppang, Norway4 aut
7001 a Mach, Orpheusu Zentrum für Rückenmarkverletzte mit Neuro-Urologie, BG Unfallklinik Murnau, 82418 Murnau am Staffelsee, Germany4 aut
7001 a Vogel, Matthiasu Zentrum für Rückenmarkverletzte mit Neuro-Urologie, BG Unfallklinik Murnau, 82418 Murnau am Staffelsee, Germany4 aut
7001 a Tiedt, Steffenu Neurologische Klinik und Poliklinik, Klinikum der Universität München, Ludwig-Maximilians- University Munich, 81377 Munich, Germany4 aut
7001 a Ormanns, Steffenu Pathologisches Institut, Klinikum der Universität München, Ludwig-Maximilians- University Munich, 81377 Munich, Germany4 aut
7001 a Kessler, Barbarau Gene Center, Ludwig-Maximilians-University Munich, 81377 Munich, Germany4 aut
7001 a Dueck, Anneu DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 80802 Munich, Germany; Institute of Pharmacology and Toxicology, Technical University of Munich, 80802 Munich, Germany4 aut
7001 a Friebe, Andreau Norwegian Institute for Nature Research, 7034 Trondheim, Norway; Scandinavian Brown Bear Research Project, Tackåsen 2, SE-79498 Orsa, Sweden4 aut
7001 a Jørgensen, Peter Godsku Herlev and Gentofte University Hospital, Borgmester Ib Juuls Vej 1, DK-2730, Herlev, Copenhagen, Denmark4 aut
7001 a Majzoub-Altweck, Moniru Institute of Veterinary Pathology, Center for Clinical Veterinary Medicine, LMU Munich, 80539 Munich, Germany4 aut
7001 a Blutke, Andreasu Institute of Veterinary Pathology, Center for Clinical Veterinary Medicine, LMU Munich, 80539 Munich, Germany4 aut
7001 a Polzin, Aminu Division of Cardiology, Pulmonology, and Vascular Medicine, Heinrich Heine University Medical Center Dusseldorf, 40225 Dusseldorf, Germany4 aut
7001 a Stark, Konstantinu Department of Cardiology, University Hospital, LMU Munich, 81377 Munich, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 80802 Munich, Germany4 aut
7001 a Kääb, Stefanu Department of Cardiology, University Hospital, LMU Munich, 81377 Munich, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 80802 Munich, Germany4 aut
7001 a Maier, Dorisu Zentrum für Rückenmarkverletzte mit Neuro-Urologie, BG Unfallklinik Murnau, 82418 Murnau am Staffelsee, Germany4 aut
7001 a Gibbins, Jonathan M.u Institute for Cardiovascular and Metabolic Research, School of Biological Sciences, Health and Life Sciences Building, University of Reading, RG6 6UR, UK4 aut
7001 a Limper, Ulrichu Institute of Aerospace Medicine, German Aerospace Center (DLR), 51147 Cologne, Germany; Department of Anesthesiology and Intensive Care Medicine, Merheim Medical Center, Hospitals of Cologne, University of Witten/Herdecke, 51109 Cologne, Germany4 aut
7001 a Fröbert, Ole,d 1964-u Örebro universitet,Institutionen för medicinska vetenskaper,Faculty of Health, Department of Cardiology, Örebro University, 701 85 Örebro, Sweden; Department of Clinical Medicine, Faculty of Health, Aarhus University, 8000 Aarhus, Denmark; Department of Clinical Pharmacology, Aarhus University Hospital, 8000 Aarhus, Denmark; Steno Diabetes Center Aarhus, Aarhus University Hospital, 8000 Aarhus, Denmark4 aut0 (Swepub:oru)oft
7001 a Mann, Matthiasu Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany4 aut
7001 a Massberg, Steffenu Department of Cardiology, University Hospital, LMU Munich, 81377 Munich, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 80802 Munich, Germany4 aut
7001 a Petzold, Tobiasu Department of Cardiology, University Hospital, LMU Munich, 81377 Munich, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 80802 Munich, Germany4 aut
7102 a Department of Cardiology, University Hospital, LMU Munich, 81377 Munich, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 80802 Munich, Germanyb Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany; Omicera Diagnostics, 82152 Martinsried, Germany4 org
7102 a Sveriges lantbruksuniversitet
7730 t Scienced : American Association for the Advancement of Science (AAAS)g 380:6641, s. 178-187q 380:6641<178-187x 0036-8075x 1095-9203
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-105529
8564 8u https://doi.org/10.1126/science.abo5044
8564 8u https://res.slu.se/id/publ/121998

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