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FältnamnIndikatorerMetadata
00003645naa a2200505 4500
001oai:gup.ub.gu.se/326570
003SwePub
008240528s2023 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:152580303
0247 a https://gup.ub.gu.se/publication/3265702 URI
0247 a https://doi.org/10.1111/petr.145202 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1525803032 URI
040 a (SwePub)gud (SwePub)ki
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Mellgren, Karin,d 1962u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics4 aut0 (Swepub:gu)xmellk
2451 0a A retrospective case-control study of gastrostomy use in children undergoing hematopoietic cell transplantation
264 1c 2023
520 a BackgroundMaintaining a good nutritional status during the hematopoietic cell transplantation (HCT) procedure is challenging in the pediatric population. MethodsIn a multicentric retrospective study, we compared the outcome of nutritional status and HCT-related parameters in 227 pediatric patients during and after HCT between 2005 and 2015. 112 patients received a gastrostomy before the start of HCT (GS group), and 115 did not receive a gastrostomy (NGS). Data collection was performed at HCT, 3, 6, and 12 months post-HCT. ResultsAt time point of HCT the Standard Deviation Score (SDS) of weight was 0.17 in the NGS group, and 0.71 in the GS group (p = .01) Patients in the NGS group lost more weight during the first 3 months after HCT than patients in the GS group. At 12 months, patients in the NGS remained at a lower weight, while patients in the GS group slightly increased their weight.There were no differences between the groups in the incidence of acute graft-versus-host-disease (GvHD), overall survival, and non-relapse mortality. However, the number of febrile episodes requiring intravenous treatment with antibiotics, was higher in the GS group as compared to the NGS group, during the first 3 months post-HCT (p < .001). ConclusionsOur results indicate that gastrostomy can be utilized in children undergoing HCT without any negative effects on mortality. Therefore, the use of a gastrostomy appears to be a safe option to maintain a good nutritional status during the HCT procedure.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Pediatrik0 (SwePub)302212 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Pediatrics0 (SwePub)302212 hsv//eng
653 a Hematopoietic stem cell transplantation
653 a gastrostomy
653 a nutritional
653 a support
653 a pediatric patients
653 a pediatric-patients
653 a cancer
653 a nutrition
653 a Pediatrics
653 a Transplantation
7001 a Nicolajsen, T.4 aut
7001 a Christoforaki, T. P.4 aut
7001 a Juan, S. M.4 aut
7001 a Martensson, T.4 aut
7001 a Toporski, J.4 aut
7001 a Casswall, T. H.u Karolinska Institutet4 aut
7001 a Gustafsson, B.u Karolinska Institutet4 aut
7102 a Göteborgs universitetb Institutionen för kliniska vetenskaper, Avdelningen för pediatrik4 org
7730 t Pediatric Transplantationg 27:4q 27:4x 1397-3142x 1399-3046
8564 8u https://gup.ub.gu.se/publication/326570
8564 8u https://doi.org/10.1111/petr.14520
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:152580303

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