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Sökning: WFRF:(Martinez Conejero José A) > (2013) > MicroRNAs miR-30b, ...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003368naa a2200349 4500
001oai:DiVA.org:uu-185544
003SwePub
008121126s2013 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1855442 URI
0247 a https://doi.org/10.1177/19337191124535072 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Altmäe, Signe,d 1978-u Competence Centre on Reproductive Medicine and Biology, Tartu, Estonia,Klinisk och experimentell reproduktionsbiologi/Olovsson4 aut0 (Swepub:uu)sigal891
2451 0a MicroRNAs miR-30b, miR-30d, and miR-494 Regulate Human Endometrial Receptivity
264 c 2013-12-30
264 1b Springer Science and Business Media LLC,c 2013
338 a print2 rdacarrier
520 a MicroRNAs (miRNAs) act as important epigenetic posttranscriptional regulators of gene expression. We aimed to gain more understanding of the complex gene expression regulation of endometrial receptivity by analyzing miRNA signatures of fertile human endometria. We set up to analyze miRNA signatures of receptive (LH + 7, n = 4) versus prereceptive (LH + 2, n = 5) endometrium from healthy fertile women. We found hsa-miR-30b and hsa-miR-30d to be significantly upregulated, and hsa-miR-494 and hsa-miR-923 to be downregulated in receptive endometrium. Three algorithms (miRanda, PicTar, and TargetScan) were used for target gene prediction. Functional analyses of the targets using Ingenuity Pathways Analysis and The Database for Annotation, Visualization and Integrated Discovery indicated roles in transcription, cell proliferation and apoptosis, and significant involvement in several relevant pathways, such as axon guidance, Wnt/β-catenin, ERK/MAPK, transforming growth factor β (TGF-β), p53 and leukocyte extravasation. Comparison of predicted miRNA target genes and our previous messenger RNA microarray data resulted in a list of 12 genes, including CAST, CFTR, FGFR2, and LIF that could serve as a panel of genes important for endometrial receptivity. In conclusion, we suggest that a subset of miRNAs and their target genes may play important roles in endometrial receptivity.
7001 a Martinez-Conejero, José Au IVIOMICS, Valencia, Spain4 aut
7001 a Esteban, Francisco Ju Department of Experimental Biology, University of Jaen, Jaen, Spain4 aut
7001 a Ruiz-Alonso, Mariau IVIOMICS, Valencia, Spain4 aut
7001 a Stavreus-Evers, Anneli,d 1955-u Uppsala universitet,Obstetrik & gynekologi,Klinisk och experimentell reproduktionsbiologi/Olovsson4 aut0 (Swepub:uu)annst384
7001 a Horcajadas, José Au Araid at IþCS, Hospital Miguel Servet, Zaragoza, Spain4 aut
7001 a Salumets, Andresu Competence Centre on Reproductive Medicine and Biology, Tartu, Estonia4 aut
7102 a Competence Centre on Reproductive Medicine and Biology, Tartu, Estoniab Klinisk och experimentell reproduktionsbiologi/Olovsson4 org
7730 t Reproductive Sciencesd : Springer Science and Business Media LLCg 20:3, s. 308-317q 20:3<308-317x 1933-7191x 1933-7205
8564 u https://europepmc.org/articles/pmc4077381?pdf=render
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-185544
8564 8u https://doi.org/10.1177/1933719112453507

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