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National Cancer Institute Think-Tank Meeting Report on Proteomic Cartography and Biomarkers at the Single-Cell Level : Interrogation of Premalignant Lesions

Kagan, Jacob (författare)
NCI, Canc Biomarkers Res Grp, Div Canc Prevent, Bethesda, MD 20892 USA.
Moritz, Robert L. (författare)
Inst Syst Biol, Seattle, WA 98109 USA.
Mazurchuk, Richard (författare)
NCI, Canc Biomarkers Res Grp, Div Canc Prevent, Bethesda, MD 20892 USA.
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Lee, Je Hyuk (författare)
Cold Spring Harbor Lab, POB 100, Cold Spring Harbor, NY 11724 USA.
Kharchenko, Peter Vasili (författare)
Harvard Med Sch, Blavatn Inst Biomed Informat, Boston, MA 02115 USA.
Rozenblatt-Rosen, Orit (författare)
Broad Inst, Klarman Cell Observ, Boston, MA USA.
Ruppin, Eytan (författare)
NCI, Canc Data Sci Lab, Ctr Canc Res, Bethesda, MD 20892 USA.
Edfors, Fredrik (författare)
KTH,Science for Life Laboratory, SciLifeLab,Systembiologi
Ginty, Fiona (författare)
GE Global Res Ctr, Life Sci & Mol Diagnost Lab, Niskayuna, NY USA.
Goltsev, Yury (författare)
Stanford Univ, Stanford Med Sch, Dept Microbiol & Immunol, Baxter Lab Stem Cell Biol, Stanford, CA 94305 USA.
Wells, James A. (författare)
Univ Calif San Francisco, Dept Pharmaceut Sci, San Francisco, CA 94143 USA.
LaCava, John (författare)
Rockefeller Univ, Lab Cellular & Struct Biol, 1230 York Ave, New York, NY 10021 USA.
Riesterer, Jessica L. (författare)
Oregon Hlth & Sci Univ, Ctr Spatial Syst Biomed, Portland, OR 97201 USA.
Germain, Ronald N. (författare)
NIAID, Lab Immune Syst Biol, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.
Shi, Tujin (författare)
Pacific Northwest Natl Lab, Biol Sci Div, Richland, WA 99352 USA.
Chee, Mark S. (författare)
Encodia Inc, San Diego, CA USA.
Budnik, Bogdan A. (författare)
Harvard Univ, Fac Arts & Sci, Div Sci, Boston, MA 02115 USA.
Yates, John R., III (författare)
Scripps Res Inst, Dept Mol Med, La Jolla, CA USA.
Chait, Brian T. (författare)
Rockefeller Univ, Lab Mass Spectrometry & Gaseous Ion Chem, 1230 York Ave, New York, NY 10021 USA.
Moffitt, Jeffery R. (författare)
Boston Childrens Hosp, Boston, MA USA.;Harvard Univ, Med Sch, Boston, MA 02115 USA.
Smith, Richard D. (författare)
Pacific Northwest Natl Lab, Biol Sci Div, Richland, WA 99352 USA.
Srivastava, Sudhir (författare)
NCI, Canc Biomarkers Res Grp, Div Canc Prevent, Bethesda, MD 20892 USA.
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NCI, Canc Biomarkers Res Grp, Div Canc Prevent, Bethesda, MD 20892 USA Inst Syst Biol, Seattle, WA 98109 USA. (creator_code:org_t)
2020-03-12
2020
Engelska.
Ingår i: Journal of Proteome Research. - : American Chemical Society (ACS). - 1535-3893 .- 1535-3907. ; 19:5, s. 1900-1912
Relaterad länk:
https://www.osti.gov...
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https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • A Think-Tank Meeting was convened by the National Cancer Institute (NCI) to solicit experts' opinion on the development and application of multiomic single-cell analyses, and especially single-cell proteomics, to improve the development of a new generation of biomarkers for cancer risk, early detection, diagnosis, and prognosis as well as to discuss the discovery of new targets for prevention and therapy. It is anticipated that such markers and targets will be based on cellular, subcellular, molecular, and functional aberrations within the lesion and within individual cells. Single-cell proteomic data will be essential for the establishment of new tools with searchable and scalable features that indude spatial and temporal cartographies of premalignant and malignant lesions. Challenges and potential solutions that were discussed included (i) The best way/s to analyze single-cells from fresh and preserved tissue; (ii) Detection and analysis of secreted molecules and from single cells, especially from a tissue slice; (iii) Detection of new, previously undocumented cell type/s in the premalignant and early stage cancer tissue microenvironment; (iv) Multiomic integration of data to support and inform proteomic measurements; (v) Subcellular organelles-identifying abnormal structure, function, distribution, and location within individual premalignant and malignant cells; (vi) How to improve the dynamic range of single-cell proteomic measurements for discovery of differentially expressed proteins and their post-translational modifications (PTM); (vii) The depth of coverage measured concurrently using single-cell techniques; (viii) Quantitation - absolute or semiquantitative? (ix) Single methodology or multiplexed combinations? (x) Application of analytical methods for identification of biologically significant subsets; (xi) Data visualization of N-dimensional data sets; (xii) How to construct intercellular signaling networks in individual cells within premalignant tumor microenvironments (TME); (xiii) Associations between intrinsic cellular processes and extrinsic stimuli; (xiv) How to predict cellular responses to stress-inducing stimuli; (xv) Identification of new markers for prediction of progression from precursor, benign, and localized lesions to invasive cancer, based on spatial and temporal changes within individual cells; (xvi) Identification of new targets for immunoprevention or immunotherapy-identification of neoantigens and surfactome of individual cells within a lesion.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinsk bioteknologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Medical Biotechnology (hsv//eng)

Nyckelord

single-cell proteomics
single-cell mass spectrometry
targeted proteomics
precursor lesion
precancer
tumorigenic lesion
lesion's heterogeneity
clonal evolution
spatial and temporal cartography
biomarkers
early detection
targets for prevention and therapy

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