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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005795naa a2200589 4500
001oai:lup.lub.lu.se:dad2bb00-7656-4bf7-9e1e-c93bc6ee01ad
003SwePub
008240111s2023 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/dad2bb00-7656-4bf7-9e1e-c93bc6ee01ad2 URI
0247 a https://doi.org/10.1093/cvr/cvac0842 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Bosmans, Laura A.u Academic Medical Center of University of Amsterdam (AMC)4 aut
2451 0a Myeloid CD40 deficiency reduces atherosclerosis by impairing macrophages’ transition into a pro-inflammatory state
264 c 2022-05-19
264 1b Oxford University Press (OUP),c 2023
300 a 15 s.
520 a Aims CD40 and its ligand, CD40L, play a critical role in driving atherosclerotic plaque development. Disrupted CD40-signalling reduces experimental atherosclerosis and induces a favourable stable plaque phenotype. We recently showed that small molecule-based inhibition of CD40-tumour necrosis factor receptor associated factor-6 interactions attenuates atherosclerosis in hyperlipidaemic mice via macrophage-driven mechanisms. The present study aims to detail the function of myeloid CD40 in atherosclerosis using myeloid-specific CD40-deficient mice. Method and Cd40flox/flox and LysM-cre Cd40flox/flox mice on an Apoe−/− background were generated (CD40wt and CD40mac−/− , respect-Results ively). Atherosclerotic lesion size, as well as plaque macrophage content, was reduced in CD40mac−/− compared to CD40wt mice, and their plaques displayed a reduction in necrotic core size. Transcriptomics analysis of the CD40mac−/− atherosclerotic aorta revealed downregulated pathways of immune pathways and inflammatory responses. Loss of CD40 in macrophages changed the representation of aortic macrophage subsets. Mass cytometry analysis revealed a higher content of a subset of alternative or resident-like CD206+CD209b− macrophages in the atherosclerotic aorta of CD40mac−/− compared to CD40wt mice. RNA-sequencing of bone marrow-derived macrophages of CD40mac−/− mice demonstrated upregulation of genes associated with alternatively activated macrophages (including Folr2, Thbs1, Sdc1, and Tns1). Conclusions We here show that absence of CD40 signalling in myeloid cells reduces atherosclerosis and limits systemic inflammation by preventing a shift in macrophage polarization towards pro-inflammatory states. Our study confirms the merit of macrophage-targeted inhibition of CD40 as a valuable therapeutic strategy to combat atherosclerosis.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
653 a Atherosclerosis
653 a CD40
653 a Inflammation
653 a Macrophage
7001 a van Tiel, Claudia M.u Academic Medical Center of University of Amsterdam (AMC)4 aut
7001 a Aarts, Suzanne A.B.M.u Academic Medical Center of University of Amsterdam (AMC)4 aut
7001 a Willemsen, Lisau Academic Medical Center of University of Amsterdam (AMC)4 aut
7001 a Baardman, Jeroenu Academic Medical Center of University of Amsterdam (AMC)4 aut
7001 a van Os, Bram W.u Academic Medical Center of University of Amsterdam (AMC)4 aut
7001 a den Toom, Myrtheu Academic Medical Center of University of Amsterdam (AMC)4 aut
7001 a Beckers, Lindau Academic Medical Center of University of Amsterdam (AMC)4 aut
7001 a Ahern, David J.u Kennedy Institute of Rheumatology4 aut
7001 a Levels, Johannes H.M.u Academic Medical Center of University of Amsterdam (AMC)4 aut
7001 a Jongejan, Aldou Academic Medical Center of University of Amsterdam (AMC)4 aut
7001 a Moerland, Perry D.u Academic Medical Center of University of Amsterdam (AMC)4 aut
7001 a Verberk, Sanne G.S.u Vrije Universiteit Amsterdam4 aut
7001 a van den Bossche, Janu Vrije Universiteit Amsterdam,Academic Medical Center of University of Amsterdam (AMC)4 aut
7001 a de Winther, Menno M.P.J.u Academic Medical Center of University of Amsterdam (AMC)4 aut
7001 a Weber, Christianu University Hospital Munich,Munich Cluster for Systems Neurology,German Centre for Cardiovascular Research,Maastricht University Medical Centre4 aut
7001 a Atzler, Dorotheeu Munich Cluster for Systems Neurology,Ludwig-Maximilian University of Munich,University Hospital Munich4 aut
7001 a Monaco, Claudiau Kennedy Institute of Rheumatology4 aut
7001 a Gerdes, Norbertu University Hospital of Düsseldorf4 aut
7001 a Shami, Annelieu Lund University,Lunds universitet,Kardiovaskulär forskning - translationella studier,Forskargrupper vid Lunds universitet,Cardiovascular Research - Translational Studies,Lund University Research Groups,Academic Medical Center of University of Amsterdam (AMC)4 aut0 (Swepub:lu)med-ais
7001 a Lutgens, Estheru Academic Medical Center of University of Amsterdam (AMC),Ludwig-Maximilian University of Munich,Mayo Clinic Minnesota,German Centre for Cardiovascular Research4 aut
7102 a Academic Medical Center of University of Amsterdam (AMC)b Kennedy Institute of Rheumatology4 org
7730 t Cardiovascular Researchd : Oxford University Press (OUP)g 119:5, s. 1146-1160q 119:5<1146-1160x 0008-6363x 1755-3245
8564 u http://dx.doi.org/10.1093/cvr/cvac084x freey FULLTEXT
8564 8u https://lup.lub.lu.se/record/dad2bb00-7656-4bf7-9e1e-c93bc6ee01ad
8564 8u https://doi.org/10.1093/cvr/cvac084

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