WFRF:(Moyle B.)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 06488naa a2200505 4500 | |
| 001 | oai:DiVA.org:oru-112591 | |
| 003 | SwePub | |
| 008 | 240325s2023 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:155148292 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-1125912 URI |
| 024 | 7 | a https://doi.org/10.1136/thorax-2023-BTSabstracts.952 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1551482922 URI |
| 040 | a (SwePub)orud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a vet2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Parker, W. A. E.u Cardiovascular Research Unit, Division of Clinical Medicine, University of Sheffield, Sheffield, UK; NIHR Sheffield Biomedical Research Centre, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK4 aut |
| 245 | 1 0 | a Prevalence of microspirometry-defined chronic obstructive pulmonary disease in two European cohorts of patients with significant smoking history hospitalised for acute myocardial infarction |
| 264 | 1 | b BMJ Publishing Group Ltd,c 2023 |
| 338 | a print2 rdacarrier | |
| 520 | a Introduction: Smoking is a major risk factor for both chronic obstructive pulmonary disease (COPD) and myocardial infarction (MI). Systemic inflammation also contributes to both diseases and has been suggested as a potential target for intervention. Prevalence of COPD in those with a significant smoking history hospitalised for MI has not been well-characterised. We sought to obtain an accurate estimate of COPD burden in this group and characterise the population.Methods: Two consecutive cohorts of patients hospitalised for MI with a smoking history of ≥10 pack-years were recruited in Sweden and the United Kingdom (UK). Baseline characteristics were recorded, including treatment with inhaled corticosteroids (ICS) and eosinophil count in blood. Microspirometry was performed using the Vitalograph COPD-6 device and symptom burden assessed using the COPD Assessment Test (CAT). The primary outcome was the prevalence of a preliminary diagnosis of clinically-significant COPD, here defined as a ratio of forced expiratory volume in 1 and 6 seconds (FEV1/FEV6) <0.7 and with FEV1 <80% of predicted value.Results: In the UK cohort, 216 participants with MI (26% female, median age 60 (IQR 53–67) years, smoking history 32 (23–45) pack-years) were recruited. The proportion with any COPD was 36%. Clinically-significant COPD was found in 30 participants (13.9%, 95% CI 9.5–19.2). Of these, 43% had a prior COPD diagnosis, 20% had an eosinophil count ≥300 cells/mm3, mean CAT score was 14.4 ± 9.3), 80% had high symptom burden (CAT score >10) and 23% were receiving ICS. The Swedish cohort included 302 participants with MI (24% female, median age 68 (IQR 61–76) years, 26 (15–38) pack years), and clinically-significant COPD was found in 52 (17.2%; 12.9–21.5). In these 52 participants, 17% had a prior COPD diagnosis, 20% had an eosinophil count ≥300 cells/mm3, mean CAT score was 12.9 ± 7.2, 63% had CAT score ≥10 and 15% had treatment with ICS.Conclusions: The prevalence of preliminary diagnosis of clinically-significant COPD in patients with a ≥10 pack-year smoking history hospitalised for MI is similar between two European cohorts and under-recognised. Further work is warranted to determine whether identification and treatment of COPD improves clinical outcomes following MI. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
| 700 | 1 | a Sundh, Josefin,d 1972-u Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Respiratory Medicine4 aut0 (Swepub:oru)jnsh |
| 700 | 1 | a Oldgren, J.u Department of Medical Sciences, Uppsala University, Uppsala, Sweden; Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden4 aut |
| 700 | 1 | a Konstantinidis, K. , Vu AstraZeneca, Cambridge, UK4 aut |
| 700 | 1 | a Lindback, J.u Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden4 aut |
| 700 | 1 | a Janson, C.u Department of Medical Sciences, Uppsala University, Uppsala, Sweden4 aut |
| 700 | 1 | a Andell, P.u Unit of Cardiology, Department of Medicine, Karolinska Institute, Stockholm, Sweden; Heart and Vascular Division, Karolinska University Hospital, Stockholm, Sweden4 aut |
| 700 | 1 | a Björkenheim, Anna,d 1980-u Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Cardiology4 aut0 (Swepub:oru)anbm |
| 700 | 1 | a Elamin, N.u Cardiovascular Research Unit, Division of Clinical Medicine, University of Sheffield, Sheffield, UK; NIHR Sheffield Biomedical Research Centre, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK4 aut |
| 700 | 1 | a McMellon, H.u Cardiovascular Research Unit, Division of Clinical Medicine, University of Sheffield, Sheffield, UK4 aut |
| 700 | 1 | a Moyle, B.u Cardiovascular Research Unit, Division of Clinical Medicine, University of Sheffield, Sheffield, UK4 aut |
| 700 | 1 | a Patel, M.u AstraZeneca, Cambridge, UK4 aut |
| 700 | 1 | a El Khoury, J.u AstraZeneca, Cambridge, UK4 aut |
| 700 | 1 | a Surujbally, R.u AstraZeneca, Cambridge, UK4 aut |
| 700 | 1 | a Storey, R. F.u Cardiovascular Research Unit, Division of Clinical Medicine, University of Sheffield, Sheffield, UK; NIHR Sheffield Biomedical Research Centre, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK4 aut |
| 700 | 1 | a James, S.u Department of Medical Sciences, Uppsala University, Uppsala, Sweden; Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden4 aut |
| 710 | 2 | a Cardiovascular Research Unit, Division of Clinical Medicine, University of Sheffield, Sheffield, UK; NIHR Sheffield Biomedical Research Centre, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UKb Institutionen för medicinska vetenskaper4 org |
| 773 | 0 | t Thoraxd : BMJ Publishing Group Ltdg 78:Suppl. 4, s. A66-A66q 78:Suppl. 4<A66-A66x 0040-6376x 1468-3296 |
| 856 | 4 | u https://doi.org/10.1136/thorax-2023-BTSabstracts.95y Fulltext |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-112591 |
| 856 | 4 8 | u https://doi.org/10.1136/thorax-2023-BTSabstracts.95 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:155148292 |
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