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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003549naa a2200517 4500
001oai:lup.lub.lu.se:8cf1e0ff-71cd-4555-af26-80e82b2eb83f
003SwePub
008160401s2002 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/3318302 URI
0247 a https://doi.org/10.1046/j.1469-1809.2002.00102.x2 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Popat, S4 aut
2451 0a Variation in the CTLA4/CD28 gene region confers an increased risk of coeliac disease
264 1b Wiley,c 2002
520 a Susceptibility to coeliae disease involves HLA and non-HLA-linked genes. The CTLA4/CD28 gene region encodes immune regulatory T-cell surface molecules and is a strong candidate as a susceptibility locus. We evaluated CTLA4/CD28 in coeliac disease by genetic linkage and association and combined Our findings with published studies through a meta-analysis. 116 multiplex families were genotyped across CTLA4/CD28 using eight markers. The contribution of CTLA4/CD28 to coeliac disease was assessed by non-parametric linkage and association analyses. Seven studies were identified that had evaluated the relationship between CTLA4/CD28 and coeliac disease and a pooled analysis of data undertaken. In our study there was evidence for a relationship between variation in the CTLA4/CD28 region and coeliae disease by linkage and association analyses. However. the findings did not attain formal statistical significance (p=0.004 and 0.039. respectively). Pooling findings with published results showed significant evidence for linkage (504 families) and association (910 families) : p values. 0.0001 and 0.0014 at D2S2214. respectively. and 0.0008 and 0.0006 at D2S116, respectively. These findings suggest that variation in the CD28/CTLA4 gene region is a determinant of coeliac disease susceptibility. Dissecting the sequence variation underlying this relationship will depend on further analyses utilising denser sets of markers.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng
7001 a Hearle, N4 aut
7001 a Hogberg, L4 aut
7001 a Braegger, CP4 aut
7001 a O'Donoghue, D4 aut
7001 a Falth-Magnusson, K4 aut
7001 a Holmes, GKT4 aut
7001 a Howdle, PD4 aut
7001 a Jenkins, H4 aut
7001 a Johnston, S4 aut
7001 a Kennedy, NP4 aut
7001 a Kumar, PJ4 aut
7001 a Logan, RFA4 aut
7001 a Marsh, MN4 aut
7001 a Mulder, CJ4 aut
7001 a Naluai, AT4 aut
7001 a Sjöberg, Klasu Lund University,Lunds universitet,Gastroenterologi,Forskargrupper vid Lunds universitet,Enheten för kroniska inflammatoriska och degenerativa sjukdomar,Gastroenterology,Lund University Research Groups,Chronic Inflammatory and Degenerative Diseases Research Unit4 aut0 (Swepub:lu)medf-ksj
7001 a Stenhammar, L4 aut
7001 a Walters, JRF4 aut
7001 a Jewell, DP4 aut
7001 a Houlston, RS4 aut
7102 a Gastroenterologib Forskargrupper vid Lunds universitet4 org
7730 t Annals of Human Geneticsd : Wileyg 66:2, s. 125-137q 66:2<125-137x 1469-1809x 0003-4800
8564 u http://dx.doi.org/10.1046/j.1469-1809.2002.00102.xy FULLTEXT
8564 8u https://lup.lub.lu.se/record/331830
8564 8u https://doi.org/10.1046/j.1469-1809.2002.00102.x

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