WFRF:(Nasim M)
Sökning: WFRF:(Nasim M) > (2004) > Idling by DNA polym...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03088naa a2200445 4500 | |
| 001 | oai:DiVA.org:umu-6352 | |
| 003 | SwePub | |
| 008 | 071209s2004 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-63522 URI |
| 024 | 7 | a https://doi.org/10.1101/gad.12523042 DOI |
| 040 | a (SwePub)umu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Garg, Parie4 aut |
| 245 | 1 0 | a Idling by DNA polymerase delta maintains a ligatable nick during lagging-strand DNA replication. |
| 264 | c 2004-11-01 | |
| 264 | 1 | b Cold Spring Harbor Laboratory,c 2004 |
| 338 | a print2 rdacarrier | |
| 520 | a During each yeast cell cycle, ∼100,000 nicks are generated during lagging-strand DNA replication. Efficient nick processing during Okazaki fragment maturation requires the coordinated action of DNA polymerase δ (Pol δ) and the FLAP endonuclease FEN1. Misregulation of this process leads to the accumulation of double-stranded breaks and cell lethality. Our studies highlight a remarkably efficient mechanism for Okazaki fragment maturation in which Pol δ by default displaces 2–3 nt of any downstream RNA or DNA it encounters. In the presence of FEN1, efficient nick translation ensues, whereby a mixture of mono- and small oligonucleotides are released. If FEN1 is absent or not optimally functional, the ability of Pol δ to back up via its 3′–5′-exonuclease activity, a process called idling, maintains the polymerase at a position that is ideal either for ligation (in case of a DNA–DNA nick) or for subsequent engagement by FEN1 (in case of a DNA–RNA nick). Consistent with the hypothesis that DNA polymerase ϵ is the leading-strand enzyme, we observed no idling by this enzyme and no cooperation with FEN1 for creating a ligatable nick. | |
| 653 | a DNA/*metabolism | |
| 653 | a DNA Helicases/metabolism | |
| 653 | a DNA Polymerase III/*metabolism | |
| 653 | a DNA Primers | |
| 653 | a DNA Replication | |
| 653 | a Exonucleases/metabolism | |
| 653 | a Flap Endonucleases/*metabolism | |
| 653 | a Oligonucleotides/metabolism | |
| 653 | a Saccharomyces cerevisiae/*enzymology/*genetics | |
| 700 | 1 | a Stith, Carrie M4 aut |
| 700 | 1 | a Sabouri, Nasimu Umeå universitet,Institutionen för medicinsk kemi och biofysik4 aut0 (Swepub:umu)namsai01 |
| 700 | 1 | a Johansson, Eriku Umeå universitet,Institutionen för medicinsk kemi och biofysik4 aut0 (Swepub:umu)erjo0002 |
| 700 | 1 | a Burgers, Peter M4 aut |
| 710 | 2 | a Umeå universitetb Institutionen för medicinsk kemi och biofysik4 org |
| 773 | 0 | t Genes & Developmentd : Cold Spring Harbor Laboratoryg 18:22, s. 2764-2773q 18:22<2764-2773x 0890-9369x 1549-5477 |
| 856 | 4 | u http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=15520275&dopt=Citation |
| 856 | 4 | u http://genesdev.cshlp.org/content/18/22/2764.full.pdf |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-6352 |
| 856 | 4 8 | u https://doi.org/10.1101/gad.1252304 |
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