SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Nordström Randi)
 

Sökning: WFRF:(Nordström Randi) > Peptide-Loaded Cubo...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00007069naa a2200757 4500
001oai:DiVA.org:ri-39268
003SwePub
008190703s2019 | |||||||||||000 ||eng|
009oai:research.chalmers.se:c5bcd522-a213-430a-a5f3-e19d04bb3226
009oai:DiVA.org:uu-390683
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:ri:diva-392682 URI
0247 a https://doi.org/10.1021/acsami.9b018262 DOI
0247 a https://research.chalmers.se/publication/5110552 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3906832 URI
040 a (SwePub)rid (SwePub)cthd (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Boge, Lukasu RISE,Yta, process och formulering,Chalmers University of Technology, Sweden,Chalmers tekniska högskola,RISE Research Institutes of Sweden,RISE Res Inst Sweden, S-50115 Boras, Sweden;Chalmers Univ Technol, Dept Chem & Chem Engn, S-41296 Gothenburg, Sweden4 aut0 (Swepub:cth)boge
2451 0a Peptide-Loaded Cubosomes Functioning as an Antimicrobial Unit against Escherichia coli
264 c 2019-05-23
264 1b American Chemical Society,c 2019
338 a print2 rdacarrier
500 a Funding details: MAX4ESSFUN, 2016-11-01, CTH-009; Funding details: 604182; Funding text 1: The authors thank Carolina Tangemö at the Centre for Cellular Imaging (CCI, University of Gothenburg, Sweden), Camilla Holmlund at Umeå core facility for electron microscopy (Umeå University, Sweden), and the National Microscopy Infrastructure, NMI (VR-RFI 2016-00968) for providing assistance in high-resolution confocal and cryogenic electron microscopy imaging. ISIS Neutron and Muon Source, Rutherford Appleton Laboratory, Didcot, U.K. (RB number: 1810031 DOI:10.5286/ISIS.E.92922658) is acknowledged for beamtime allocation from the Science and Technology Facilities Council. Adrian Rennie (Uppsala University, Sweden) is greatly acknowledged for fruitful discussions about NR data. Financial support was obtained from the European Union’s Seventh Framework Program grant agreement No. 604182 within the FORMAMP project (L.B and L.R. and R.N.) and from RISE Research Institutes of Sweden (Stockholm, Sweden) (L.B., L.R., M.H., and J.S.-C.). Financial support is also acknowledged from the LEO Foundation Center for Cutaneous Drug Delivery (grant number 2016-11-01; K.L.B. and L.S.E.D.) and MAX4ESSFUN (grant number CTH-009; L.B., K.L.B., and M.A.).
520 a Dispersions of cubic liquid crystalline phases, also known as cubosomes, have shown great promise as delivery vehicles for a wide range of medicines. Due to their ordered structure, comprising alternating hydrophilic and hydrophobic domains, cubosomes possess unique delivery properties and compatibility with both water-soluble and -insoluble drugs. However, the drug delivery mechanism and cubosome interaction with human cells and bacteria are still poorly understood. Herein, we reveal how cubosomes loaded with the human cathelicidin antimicrobial peptide LL-37, a system with high bacteria-killing effect, interact with the bacterial membrane and provide new insights into the eradication mechanism. Combining the advanced experimental techniques neutron reflectivity and quartz crystal microbalance with dissipation monitoring, a mechanistic drug delivery model for LL-37-loaded cubosomes on bacterial mimicking bilayers was constructed. Moreover, the cubosome interaction with Escherichia coli was directly visualized using super-resolution laser scanning microscopy and cryogenic electron tomography. We could conclude that cubosomes loaded with LL-37 adsorbed and distorted bacterial membranes, providing evidence that the peptide-loaded cubosomes function as an antimicrobial unit.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmaceutiska vetenskaper0 (SwePub)301012 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmaceutical Sciences0 (SwePub)301012 hsv//eng
650 7a NATURVETENSKAPx Kemix Fysikalisk kemi0 (SwePub)104022 hsv//swe
650 7a NATURAL SCIENCESx Chemical Sciencesx Physical Chemistry0 (SwePub)104022 hsv//eng
650 7a NATURVETENSKAPx Biologix Strukturbiologi0 (SwePub)106012 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Structural Biology0 (SwePub)106012 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmakologi och toxikologi0 (SwePub)301022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmacology and Toxicology0 (SwePub)301022 hsv//eng
653 a antimicrobial peptide
653 a bacteria
653 a cubosome
653 a LL-37
653 a membrane
653 a Controlled drug delivery
653 a Electric impedance tomography
653 a Escherichia coli
653 a Membranes
653 a Peptides
653 a Targeted drug delivery
653 a Cubosomes
653 a Experimental techniques
653 a Hydrophilic and hydrophobic
653 a Laser scanning microscopy
653 a Liquid-crystalline phasis
653 a Quartz crystal microbalance with dissipation monitoring
653 a Drug interactions
7001 a Browning, Kathrynu University of Copenhagen, Denmark,Köpenhamns universitet,Univ Copenhagen, Dept Pharm, DK-2100 Copenhagen, Denmark4 aut
7001 a Nordström, Randiu Uppsala universitet,Institutionen för farmaci4 aut0 (Swepub:uu)ranra372
7001 a Campana, Mariou Rutherford Appleton Laboratory, UK,STFC Rutherford Appleton Laboratory,Rutherford Appleton Lab, Didcot OX11 0DE, Oxon, England4 aut
7001 a Damgaard, Livu University of Copenhagen, Denmark,Köpenhamns universitet,Univ Copenhagen, Dept Pharm, DK-2100 Copenhagen, Denmark4 aut
7001 a Seth Caous, Josefinu RISE,Kemi och material,Metodik för produktframtagning,RISE Research Institutes of Sweden,RISE Res Inst Sweden, S-50115 Boras, Sweden4 aut0 (Swepub:ri)josefinca@ri.se
7001 a Hellsing, Majau RISE,Yta, process och formulering,RISE Research Institutes of Sweden,RISE Res Inst Sweden, S-50115 Boras, Sweden4 aut
7001 a Ringstad, Lovisau RISE,Kemi och material,RISE Research Institutes of Sweden,RISE Res Inst Sweden, S-50115 Boras, Sweden4 aut
7001 a Andersson, Martin,d 1974u Chalmers University of Technology, Sweden,Chalmers tekniska högskola,Chalmers Univ Technol, Dept Chem & Chem Engn, S-41296 Gothenburg, Sweden4 aut0 (Swepub:cth)martina
7102 a RISEb Yta, process och formulering4 org
7730 t ACS Applied Materials and Interfacesd : American Chemical Societyg 11:24, s. 21314-21322q 11:24<21314-21322x 1944-8244x 1944-8252
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:ri:diva-39268
8564 8u https://doi.org/10.1021/acsami.9b01826
8564 8u https://research.chalmers.se/publication/511055
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-390683

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy