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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006909naa a2200481 4500
001oai:DiVA.org:umu-215391
003SwePub
008231027s2023 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-2153912 URI
0247 a https://doi.org/10.1002/mdc3.138762 DOI
040 a (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Wirth, Thomasu Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology and the National Hospital for Neurology and Neurosurgery, London, United Kingdom; Neurology Department, Strasbourg University Hospital, Strasbourg, France; Institute of Genetics and Cellular and Molecular Biology, INSERM-U964, CNRS-UMR7104, University of Strasbourg, Strasbourg, France; Strasbourg Translational Medicine Federation, University of Strasbourg, Strasbourg, France4 aut
2451 0a Parkinson's disease tremor differentially responds to levodopa and subthalamic stimulation
264 1b John Wiley & Sons,c 2023
338 a print2 rdacarrier
520 a Background: Tremor in Parkinson's disease (PD) has an inconsistent response to levodopa and subthalamic deep brain stimulation (STN-DBS).Objectives: To identify predictive factors of PD tremor responsiveness to levodopa and STN-DBS.Material and Methods: PD patients with upper limb tremor who underwent STN-DBS were included. The levodopa responsiveness of tremor (overall, postural, and rest sub-components), was assessed using the relevant Unified Parkinson's Disease Rating Scale-III items performed during the preoperative assessment. Post-surgical outcomes were similarly assessed ON and OFF stimulation. A score for the rest/postural tremor ratio was used to determine the influence of rest and postural tremor severity on STN-DBS outcome. Factors predictive of tremor responsiveness were determined using multiple linear regression modeling. Volume of tissue activated measurement coupled to voxel-based analysis was performed to identify anatomical clusters associated with motor symptoms improvement.Results: One hundred and sixty five patients were included in this study. Male gender was negatively correlated with tremor responsiveness to levodopa, whereas the ratio of rest/postural tremor was positively correlated with both levodopa responsiveness and STN-DBS tremor outcome. Clusters corresponding to improvement of tremor were in the subthalamic nucleus, the zona incerta and the thalamus, whereas clusters corresponding to improvement for akinesia and rigidity were located within the subthalamic nucleus.Conclusion: More severe postural tremor and less severe rest tremor were associated with both poorer levodopa and STN-DBS response. The different locations of clusters associated with best correction of tremor and other parkinsonian features suggest that STN-DBS effect on PD symptoms is underpinned by the modulation of different networks.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng
653 a levodopa
653 a Parkinson's disease
653 a subthalamic stimulation
653 a tremor
653 a volume of tissue activated
7001 a Ferreira, Franciscau Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology and the National Hospital for Neurology and Neurosurgery, London, United Kingdom; Wellcome Centre for Human Neuroimaging, London, United Kingdom4 aut
7001 a Vijiaratnam, Nirosenu Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology and the National Hospital for Neurology and Neurosurgery, London, United Kingdom4 aut
7001 a Girges, Christineu Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology and the National Hospital for Neurology and Neurosurgery, London, United Kingdom4 aut
7001 a Pakzad, Ashkanu EPSRC Centre for Doctoral Training i4health, University College London, London, United Kingdom4 aut
7001 a de Roquemaurel, Alexisu Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology and the National Hospital for Neurology and Neurosurgery, London, United Kingdom4 aut
7001 a Sinani, Olgau Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology and the National Hospital for Neurology and Neurosurgery, London, United Kingdom4 aut
7001 a Hyam, Jonathanu Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology and the National Hospital for Neurology and Neurosurgery, London, United Kingdom4 aut
7001 a Hariz, Marwanu Umeå universitet,Neurovetenskaper,Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology and the National Hospital for Neurology and Neurosurgery, London, United Kingdom4 aut0 (Swepub:umu)hama0032
7001 a Zrinzo, Ludvicu Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology and the National Hospital for Neurology and Neurosurgery, London, United Kingdom4 aut
7001 a Akram, Harithu Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology and the National Hospital for Neurology and Neurosurgery, London, United Kingdom4 aut
7001 a Limousin, Patriciau Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology and the National Hospital for Neurology and Neurosurgery, London, United Kingdom4 aut
7001 a Foltynie, Thomasu Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology and the National Hospital for Neurology and Neurosurgery, London, United Kingdom4 aut
7102 a Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology and the National Hospital for Neurology and Neurosurgery, London, United Kingdom; Neurology Department, Strasbourg University Hospital, Strasbourg, France; Institute of Genetics and Cellular and Molecular Biology, INSERM-U964, CNRS-UMR7104, University of Strasbourg, Strasbourg, France; Strasbourg Translational Medicine Federation, University of Strasbourg, Strasbourg, Franceb Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology and the National Hospital for Neurology and Neurosurgery, London, United Kingdom; Wellcome Centre for Human Neuroimaging, London, United Kingdom4 org
7730 t Movement Disorders Clinical Practiced : John Wiley & Sonsg 10:11, s. 1639-1649q 10:11<1639-1649x 2330-1619
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-215391
8564 8u https://doi.org/10.1002/mdc3.13876

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