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FältnamnIndikatorerMetadata
00008380naa a2201129 4500
001oai:gup.ub.gu.se/100357
003SwePub
008240528s2008 | |||||||||||000 ||eng|
009oai:lup.lub.lu.se:708e5202-accf-49d1-9db8-85f6186a02b2
009oai:DiVA.org:uu-105474
009oai:prod.swepub.kib.ki.se:117783253
009oai:DiVA.org:liu-50265
0247 a https://gup.ub.gu.se/publication/1003572 URI
0247 a https://doi.org/10.1016/j.radonc.2008.07.0192 DOI
0247 a https://lup.lub.lu.se/record/12841302 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1054742 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1177832532 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-502652 URI
040 a (SwePub)gud (SwePub)lud (SwePub)uud (SwePub)kid (SwePub)liu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Baumann, Piau Karolinska Institutet,Divisions of Oncology, Hospital Physics, Radiumhemment, Sweden4 aut
2451 0a Stereotactic body radiotherapy for medically inoperable patients with stage I non-small cell lung cancer - a first report of toxicity related to COPD/CVD in a non-randomized prospective phase II study.
264 1b Elsevier BV,c 2008
520 a BACKGROUND AND AIMS: In a retrospective study using stereotactic body radiotherapy (SBRT) in medically inoperable patients with stage I NSCLC we previously reported a local control rate of 88% utilizing a median dose of 15Gyx3. This report records the toxicity encountered in a prospective phase II trial, and its relation to coexisting chronic obstructive pulmonary disease (COPD) and cardio vascular disease (CVD). MATERIAL AND METHODS: Sixty patients were entered in the study between August 2003 and September 2005. Fifty-seven patients (T1 65%, T2 35%) with a median age of 75 years (59-87 years) were evaluable. The baseline mean FEV1% was 64% and median Karnofsky index was 80. A total dose of 45Gy was delivered in three fractions at the 67% isodose of the PTV. Clinical, pulmonary and radiological evaluations were made at 6 weeks, 3, 6, 9, 12, 18, and 36 months post-SBRT. Toxicity was graded according to CTC v2.0 and performance status was graded according to the Karnofsky scale. RESULTS: At a median follow-up of 23 months, 2 patients had relapsed locally. No grade 4 or 5 toxicity was reported. Grade 3 toxicity was seen in 12 patients (21%). There was no significant decline of FEV1% during follow-up. Low grade pneumonitis developed to the same extent in the CVD 3/17 (18%) and COPD 7/40 (18%) groups. The incidence of fibrosis was 9/17 (53%) and pleural effusions was 8/17 (47%) in the CVD group compared with 13/40 (33%) and 5/40 (13%) in the COPD group. CONCLUSION: SBRT for stage I NSCLC patients who are medically inoperable because of COPD and CVD results in a favourable local control rate with a low incidence of grade 3 and no grade 4 or 5 toxicity.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Radiologi och bildbehandling0 (SwePub)302082 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Radiology, Nuclear Medicine and Medical Imaging0 (SwePub)302082 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng
653 a Aged
653 a Aged
653 a 80 and over
653 a Carcinoma
653 a Non-Small-Cell Lung
653 a pathology
653 a physiopathology
653 a radiotherapy
653 a Cardiovascular Diseases
653 a complications
653 a Chi-Square Distribution
653 a Dose Fractionation
653 a Female
653 a Humans
653 a Lung Neoplasms
653 a pathology
653 a physiopathology
653 a radiotherapy
653 a Male
653 a Middle Aged
653 a Neoplasm Staging
653 a Prospective Studies
653 a Pulmonary Disease
653 a Chronic Obstructive
653 a complications
653 a Radiosurgery
653 a methods
653 a Radiotherapy Dosage
653 a Respiratory Function Tests
653 a Retrospective Studies
653 a Treatment Outcome
653 a COPD
653 a SBRT
653 a Inoperable stage I NSCLC
653 a CVD
653 a MEDICINE
7001 a Nyman, Jan,d 1956u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences,Department of Oncology and Radiation Physics, Sahlgrenska University Hospital, Gothenburg, Sweden4 aut0 (Swepub:gu)xnymja
7001 a Hoyer, Mortenu Divisions of Oncology and Medical Physics, Aarhus University Hospital, Denmark4 aut
7001 a Gagliardi, Giovannau Karolinska Institutet,Divisions of Oncology, Hospital Physics, Radiumhemment, Sweden4 aut
7001 a Lax, Ingmaru Karolinska Institutet,Divisions of Oncology, Hospital Physics, Radiumhemment, Sweden4 aut
7001 a Wennberg, Beritu Karolinska Institutet,Divisions of Oncology, Hospital Physics, Radiumhemment, Sweden4 aut
7001 a Drugge, Ninniu Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences,Department of Oncology and Radiation Physics, Sahlgrenska University Hospital, Gothenburg, Sweden4 aut
7001 a Ekberg, Larsu Divisions of Oncology, Hospital Physics, Malmö University Hospital, Sweden4 aut
7001 a Friesland, Signeu Karolinska Institutet,Divisions of Oncology, Hospital Physics, Radiumhemment, Sweden4 aut
7001 a Johansson, Karl-Axelu Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences,Department of Oncology and Radiation Physics, Sahlgrenska University Hospital, Gothenburg, Sweden4 aut
7001 a Lund, Jo-Smund4 aut
7001 a Morhed, Elisabethu Department of Oncology and Radiotherapy, Akademiska University Hospital, Uppsala, Sweden4 aut
7001 a Nilsson, Kristinau Uppsala universitet,Enheten för onkologi,Department of Oncology and Radiotherapy, Akademiska University Hospital, Uppsala, Sweden4 aut0 (Swepub:uu)kristnil
7001 a Levin, Ninau Department of Oncology, Trondheim University Hospital, Norway4 aut
7001 a Paludan, Mereteu Divisions of Oncology and Medical Physics, Aarhus University Hospital, Denmark4 aut
7001 a Sederholm, Christeru Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Lungmedicin,Lungmedicinska kliniken US4 aut0 (Swepub:liu)chrse81
7001 a Traberg, Andersu Divisions of Oncology and Medical Physics, Aarhus University Hospital, Denmark4 aut
7001 a Wittgren, Lenau Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine,Divisions of Oncology, Hospital Physics, Malmö University Hospital, Sweden4 aut0 (Swepub:lu)rfa-lwi
7001 a Lewensohn, Rolfu Karolinska Institutet,Divisions of Oncology, Hospital Physics, Radiumhemment, Sweden4 aut
7001 a Lund, JAu Lund, J.-Å., Department of Oncology, Trondheim University Hospital, Norway4 aut
7102 a Karolinska Institutetb Divisions of Oncology, Hospital Physics, Radiumhemment, Sweden4 org
7730 t Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncologyd : Elsevier BVg 88:3, s. 359-67q 88:3<359-67x 0167-8140x 1879-0887
8564 u http://dx.doi.org/10.1016/j.radonc.2008.07.019y FULLTEXT
8564 8u https://gup.ub.gu.se/publication/100357
8564 8u https://doi.org/10.1016/j.radonc.2008.07.019
8564 8u https://lup.lub.lu.se/record/1284130
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-105474
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:117783253
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-50265

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