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Multidisciplinary d...
Multidisciplinary development of the Geriatric Core Dataset for clinical research in older patients with cancer: A French initiative with international survey
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Paillaud, E. (författare)
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Soubeyran, P. (författare)
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Caillet, P. (författare)
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Cudennec, T. (författare)
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Brain, E. (författare)
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Terret, C. (författare)
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Etchepare, F. (författare)
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Mourey, L. (författare)
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Aparicio, T. (författare)
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Pamoukdjian, F. (författare)
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- Audisio, Riccardo A (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery
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Rostoft, S. (författare)
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Hurria, A. (författare)
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Bellera, C. (författare)
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Mathoulin-Pelissier, S. (författare)
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(creator_code:org_t)
- Elsevier BV, 2018
- 2018
- Engelska.
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Ingår i: European Journal of Cancer. - : Elsevier BV. - 0959-8049. ; 103, s. 61-68
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Background: To define a core set of geriatric data to be methodically collected in clinical cancer trials of older adults, enabling comparison across trials. Patients and methods: Following a consensus approach, a panel of 14 geriatricians from oncology clinics identified seven domains of importance in geriatric assessment. Based on the international recommendations, geriatricians selected the mostly commonly used tools/items for geriatric assessment by domain (January-October 2015). The Geriatric Core Dataset (G-CODE) was progressively developed according to RAND appropriateness ratings and feedback during three successive Delphi rounds (July-September 2016). The face validity of the G-CODE was assessed with two large panels of health professionals (55 national and 42 international experts) involved both in clinical practice and cancer trials (March-September 2017). Results and discussion: After the last Delphi round, the tools/items proposed for the G-CODE were the following: (1) social assessment: living alone or support requested to stay at home; (2) functional autonomy: Activities of Daily Living (ADL) questionnaire and short instrumental ADL questionnaire; (3) mobility: Timed Up and Go test; (4) nutrition: weight loss during the past 6 months and body mass index; (5) cognition: Mini-Cog test; (6) mood: mini-Geriatric Depression Scale and (7) comorbidity: updated Charlson Comorbidity Index. More than 70% of national experts (42 from 20 cities) and international experts (31 from 13 countries) participated. National and international surveys showed good acceptability of the G-CODE. Specific points discussed included age-year cut-off, threshold of each tool/item and information about social support, but no additional item was proposed. Conclusion: We achieved formal consensus on a set of geriatric data to be collected in cancer trials of older patients. The dissemination and prospective use of the G-CODE is needed to assess its utility. (C) 2018 Elsevier Ltd. All rights reserved.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Clinical trials
- Data set
- Delphi consensus
- Geriatric assessment
- Cancer
- Older patients
- elderly-patients
- 1st-line chemotherapy
- task-force
- feasibility
- depression
- oncology
- methodology
- validation
- predictors
- dementia
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Paillaud, E.
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Soubeyran, P.
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Caillet, P.
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Cudennec, T.
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Brain, E.
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Terret, C.
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visa fler...
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Etchepare, F.
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Mourey, L.
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Aparicio, T.
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Pamoukdjian, F.
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Audisio, Riccard ...
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Rostoft, S.
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Hurria, A.
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Bellera, C.
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Mathoulin-Peliss ...
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visa färre...
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Göteborgs universitet