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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04224naa a2201021 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:147389237 | |
| 003 | SwePub | |
| 008 | 240701s2021 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1473892372 URI |
| 024 | 7 | a https://doi.org/10.1084/jem.202105542 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Bastard, P4 aut |
| 245 | 1 0 | a Preexisting autoantibodies to type I IFNs underlie critical COVID-19 pneumonia in patients with APS-1 |
| 264 | c 2021-04-23 | |
| 264 | 1 | b Rockefeller University Press,c 2021 |
| 520 | a Patients with biallelic loss-of-function variants of AIRE suffer from autoimmune polyendocrine syndrome type-1 (APS-1) and produce a broad range of autoantibodies (auto-Abs), including circulating auto-Abs neutralizing most type I interferons (IFNs). These auto-Abs were recently reported to account for at least 10% of cases of life-threatening COVID-19 pneumonia in the general population. We report 22 APS-1 patients from 21 kindreds in seven countries, aged between 8 and 48 yr and infected with SARS-CoV-2 since February 2020. The 21 patients tested had auto-Abs neutralizing IFN-α subtypes and/or IFN-ω; one had anti–IFN-β and another anti–IFN-ε, but none had anti–IFN-κ. Strikingly, 19 patients (86%) were hospitalized for COVID-19 pneumonia, including 15 (68%) admitted to an intensive care unit, 11 (50%) who required mechanical ventilation, and four (18%) who died. Ambulatory disease in three patients (14%) was possibly accounted for by prior or early specific interventions. Preexisting auto-Abs neutralizing type I IFNs in APS-1 patients confer a very high risk of life-threatening COVID-19 pneumonia at any age. | |
| 700 | 1 | a Orlova, E4 aut |
| 700 | 1 | a Sozaeva, L4 aut |
| 700 | 1 | a Levy, R4 aut |
| 700 | 1 | a James, A4 aut |
| 700 | 1 | a Schmitt, MM4 aut |
| 700 | 1 | a Ochoa, S4 aut |
| 700 | 1 | a Kareva, M4 aut |
| 700 | 1 | a Rodina, Y4 aut |
| 700 | 1 | a Gervais, A4 aut |
| 700 | 1 | a Le Voyer, T4 aut |
| 700 | 1 | a Rosain, J4 aut |
| 700 | 1 | a Philippot, Q4 aut |
| 700 | 1 | a Neehus, AL4 aut |
| 700 | 1 | a Shaw, E4 aut |
| 700 | 1 | a Migaud, M4 aut |
| 700 | 1 | a Bizien, L4 aut |
| 700 | 1 | a Ekwall, O4 aut |
| 700 | 1 | a Berg, S4 aut |
| 700 | 1 | a Beccuti, G4 aut |
| 700 | 1 | a Ghizzoni, L4 aut |
| 700 | 1 | a Thiriez, G4 aut |
| 700 | 1 | a Pavot, A4 aut |
| 700 | 1 | a Goujard, C4 aut |
| 700 | 1 | a Fremond, ML4 aut |
| 700 | 1 | a Carter, E4 aut |
| 700 | 1 | a Rothenbuhler, A4 aut |
| 700 | 1 | a Linglart, A4 aut |
| 700 | 1 | a Mignot, B4 aut |
| 700 | 1 | a Comte, A4 aut |
| 700 | 1 | a Cheikh, N4 aut |
| 700 | 1 | a Hermine, O4 aut |
| 700 | 1 | a Breivik, L4 aut |
| 700 | 1 | a Husebye, ES4 aut |
| 700 | 1 | a Humbert, S4 aut |
| 700 | 1 | a Rohrlich, P4 aut |
| 700 | 1 | a Coaquette, A4 aut |
| 700 | 1 | a Vuoto, F4 aut |
| 700 | 1 | a Faure, K4 aut |
| 700 | 1 | a Mahlaoui, N4 aut |
| 700 | 1 | a Kotnik, P4 aut |
| 700 | 1 | a Battelino, T4 aut |
| 700 | 1 | a Podkrajsek, KT4 aut |
| 700 | 1 | a Kisand, K4 aut |
| 700 | 1 | a Ferre, EMN4 aut |
| 700 | 1 | a DiMaggio, T4 aut |
| 700 | 1 | a Rosen, LB4 aut |
| 700 | 1 | a Burbelo, PD4 aut |
| 700 | 1 | a McIntyre, M4 aut |
| 700 | 1 | a Kann, NY4 aut |
| 700 | 1 | a Shcherbina, A4 aut |
| 700 | 1 | a Pavlova, M4 aut |
| 700 | 1 | a Kolodkina, A4 aut |
| 700 | 1 | a Holland, SM4 aut |
| 700 | 1 | a Zhang, SY4 aut |
| 700 | 1 | a Crow, YJ4 aut |
| 700 | 1 | a Notarangelo, LD4 aut |
| 700 | 1 | a Su, HC4 aut |
| 700 | 1 | a Abel, L4 aut |
| 700 | 1 | a Anderson, MS4 aut |
| 700 | 1 | a Jouanguy, E4 aut |
| 700 | 1 | a Neven, B4 aut |
| 700 | 1 | a Puel, A4 aut |
| 700 | 1 | a Casanova, JL4 aut |
| 700 | 1 | a Lionakis, MS4 aut |
| 773 | 0 | t The Journal of experimental medicined : Rockefeller University Pressg 218:7q 218:7x 1540-9538x 0022-1007 |
| 856 | 4 | u https://rupress.org/jem/article-pdf/218/7/e20210554/1413883/jem_20210554.pdf |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:147389237 |
| 856 | 4 8 | u https://doi.org/10.1084/jem.20210554 |
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- Bastard, P
- Orlova, E
- Sozaeva, L
- Levy, R
- James, A
- Schmitt, MM
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- Ochoa, S
- Kareva, M
- Rodina, Y
- Gervais, A
- Le Voyer, T
- Rosain, J
- Philippot, Q
- Neehus, AL
- Shaw, E
- Migaud, M
- Bizien, L
- Ekwall, O
- Berg, S
- Beccuti, G
- Ghizzoni, L
- Thiriez, G
- Pavot, A
- Goujard, C
- Fremond, ML
- Carter, E
- Rothenbuhler, A
- Linglart, A
- Mignot, B
- Comte, A
- Cheikh, N
- Hermine, O
- Breivik, L
- Husebye, ES
- Humbert, S
- Rohrlich, P
- Coaquette, A
- Vuoto, F
- Faure, K
- Mahlaoui, N
- Kotnik, P
- Battelino, T
- Podkrajsek, KT
- Kisand, K
- Ferre, EMN
- DiMaggio, T
- Rosen, LB
- Burbelo, PD
- McIntyre, M
- Kann, NY
- Shcherbina, A
- Pavlova, M
- Kolodkina, A
- Holland, SM
- Zhang, SY
- Crow, YJ
- Notarangelo, LD
- Su, HC
- Abel, L
- Anderson, MS
- Jouanguy, E
- Neven, B
- Puel, A
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