WFRF:(Peilot Sjögren Helena 1974)
Sökning: WFRF:(Peilot Sjögren Helena 1974) > PPARalpha activatio...
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
PPARalpha activation increases triglyceride mass and adipose differentiation-related protein in hepatocytes.
-
- Edvardsson, Ulrika, 1967 (författare)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory
-
- Ljungberg, Anna, 1977 (författare)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory
-
- Lindén, Daniel, 1971 (författare)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory
- visa fler...
- William-Olsson, Lena (författare)
- Ahnmark, Andrea (författare)
- visa färre...
- (creator_code:org_t)
- 2006
- 2006
- Engelska.
- Ingår i: Journal of lipid research. - 0022-2275. ; 47:2, s. 329-40
- Tidskriftsartikel (refereegranskat)
Abstract
Ämnesord
Stäng
- Adipose differentiation-related protein (ADRP) is a lipid droplet-associated protein that is expressed in various tissues. In mice treated with the peroxisome proliferator-activated receptor alpha (PPARalpha) agonist Wy14,643 (Wy), hepatic mRNA and protein levels of ADRP as well as hepatic triglyceride content increased. Also in primary mouse hepatocytes, Wy increased ADRP expression and intracellular triglyceride mass. The triglyceride mass increased in spite of unchanged triglyceride biosynthesis and increased palmitic acid oxidation. However, Wy incubation decreased the secretion of newly synthesized triglycerides, whereas apolipoprotein B secretion increased. Thus, decreased availability of triglycerides for VLDL assembly could help to explain the cellular accumulation of triglycerides after Wy treatment. We hypothesized that this effect could be mediated by increased ADRP expression. Similar to PPARalpha activation, adenovirus-mediated ADRP overexpression in mouse hepatocytes enhanced cellular triglyceride mass and decreased the secretion of newly synthesized triglycerides. In ADRP-overexpressing cells, Wy incubation resulted in a further decrease in triglyceride secretion. This effect of Wy was not attributable to decreased cellular triglycerides after increased fatty acid oxidation because the triglyceride mass in Wy-treated ADRP-overexpressing cells was unchanged. In summary, PPARalpha activation prevents the availability of triglycerides for VLDL assembly and increases hepatic triglyceride content in part by increasing the expression of ADRP.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
Nyckelord
- Acyl-CoA Dehydrogenase
- Long-Chain
- genetics
- Acyl-CoA Oxidase
- genetics
- Animals
- Apolipoprotein B-100
- Apolipoprotein B-48
- Apolipoproteins B
- secretion
- Carnitine O-Palmitoyltransferase
- genetics
- Dietary Fats
- administration & dosage
- pharmacology
- Gene Expression
- drug effects
- genetics
- Hepatocytes
- drug effects
- metabolism
- secretion
- Liver
- drug effects
- metabolism
- Membrane Proteins
- genetics
- metabolism
- Mice
- Mice
- Inbred C57BL
- Mice
- Knockout
- Oxidation-Reduction
- PPAR alpha
- antagonists & inhibitors
- genetics
- metabolism
- Palmitic Acid
- metabolism
- Peroxisome Proliferators
- pharmacology
- Pyrimidines
- pharmacology
- Transfection
- Triglycerides
- biosynthesis
- metabolism
- secretion
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
- Journal of lipid research (Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
Hitta mer i SwePub
- Av författaren/redakt...
- Edvardsson, Ulri ...
- Ljungberg, Anna, ...
- Lindén, Daniel, ...
- William-Olsson, ...
- Peilot-Sjögren, ...
- Ahnmark, Andrea
- visa fler...
- Oscarsson, Jan, ...
- visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
- MEDICIN OCH HÄLS ...
- och Medicinska och f ...
- och Fysiologi
- Artiklar i publikationen
- Journal of lipid ...
- Av lärosätet
- Göteborgs universitet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
