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FältnamnIndikatorerMetadata
00004301naa a2200421 4500
001oai:prod.swepub.kib.ki.se:131628045
003SwePub
008240701s2015 | |||||||||||000 ||eng|
009oai:DiVA.org:uu-269775
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1316280452 URI
0247 a https://doi.org/10.1210/jc.2014-35712 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2697752 URI
040 a (SwePub)kid (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Brozzetti, Au Univ Perugia, Dept Internal Med, I-06126 Perugia, Italy.4 aut
2451 0a Autoantibody response against NALP5/MATER in primary ovarian insufficiency and in autoimmune Addison's disease
264 1b The Endocrine Society,c 2015
520 a Context:NACHT leucine-rich-repeat protein 5 (NALP5)/maternal antigen that embryo requires (MATER) is an autoantigen in hypoparathyroidism associated with autoimmune polyendocrine syndrome type 1 (APS1) but is also expressed in the ovary. Mater is an autoantigen in experimental autoimmune oophoritis.Objectives:The objectives of the study were to determine the frequency of NALP5/MATER autoantibodies (NALP5/MATER-Ab) in women with premature ovarian insufficiency (POI) and in patients with autoimmune Addison's disease (AAD) and to evaluate whether inhibin chains are a target for autoantibodies in POI.Methods:Autoantibodies against NALP5/MATER and inhibin chains-α and -βA were determined by radiobinding assays in 172 patients with AAD without clinical signs of gonadal insufficiency, 41 women with both AAD and autoimmune POI [steroidogenic cell autoimmune POI (SCA-POI)], 119 women with idiopathic POI, 19 patients with APS1, and 211 healthy control subjects.Results:NALP5/MATER-Ab were detected in 11 of 19 (58%) sera from APS1 patients, 12 of 172 (7%) AAD sera, 5 of 41 (12%) SCA-POI sera, 0 of 119 idiopathic POI sera and 1 of 211 healthy control sera (P < .001). None of 160 POI sera, including 41 sera from women with SCA-POI and 119 women with idiopathic POI, and none of 211 healthy control sera were positive for inhibin chain-α/βA autoantibodies.Conclusions:NALP5/MATER-Ab are associated with hypoparathyroidism in APS1 but are present also in patients with AAD and in women with SCA-POI without hypoparathyroidism. Inhibin chains do not appear to be likely candidate targets of autoantibodies in human POI.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
7001 a Alimohammadi, Mohammadu Uppsala universitet,Dermatologi och venereologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)moali133
7001 a Morelli, Su Univ Perugia, Dept Internal Med, I-06126 Perugia, Italy.4 aut
7001 a Minarelli, Vu Univ Perugia, Dept Internal Med, I-06126 Perugia, Italy.4 aut
7001 a Hallgren, Au Karolinska Inst, Dept Med Solna, Ctr Mol Med, S-17176 Stockholm, Sweden.4 aut
7001 a Giordano, Ru Univ Turin, Dept Med Sci, Div Endocrinol Diabetol & Metab, I-10126 Turin, Italy.4 aut
7001 a De Bellis, Au Univ Naples 2, Endocrinol Unit, Dept Cardiothorac & Resp Sci, I-80132 Naples, Italy.4 aut
7001 a Perniola, Ru V Fazzi Reg Hosp, Dept Pediat Neonatal Intens Care, I-73100 Lecce, Italy.4 aut
7001 a Kämpe, Olleu Uppsala universitet,Karolinska Institutet,Autoimmunitet,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)ollekamp
7001 a Falorni, Au Univ Perugia, Dept Internal Med, I-06126 Perugia, Italy4 aut
7102 a Univ Perugia, Dept Internal Med, I-06126 Perugia, Italy.b Dermatologi och venereologi4 org
7730 t The Journal of clinical endocrinology and metabolismd : The Endocrine Societyg 100:5, s. 1941-1948q 100:5<1941-1948x 1945-7197x 0021-972X
8564 u https://academic.oup.com/jcem/article-pdf/100/5/1941/10855096/jcem1941.pdf
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:131628045
8564 8u https://doi.org/10.1210/jc.2014-3571
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-269775

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