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Sökning: WFRF:(Poulsen K T) > (1987-1989) > Antibodies to a 64,...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003922naa a2200589 4500
001oai:lup.lub.lu.se:366fb20e-1e1d-4e95-b91a-f7350d6d1b0e
003SwePub
008210917s1987 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/366fb20e-1e1d-4e95-b91a-f7350d6d1b0e2 URI
0247 a https://doi.org/10.1172/JCI1129032 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Baekkeskov, S4 aut
2451 0a Antibodies to a 64,000 Mr human islet cell antigen precede the clinical onset of insulin-dependent diabetes
264 1c 1987
520 a Antibodies in sera from newly diagnosed insulin-dependent diabetes mellitus (IDDM) patients are directed to a human islet cell protein of relative molecular mass (Mr) 64,000. Since IDDM seems to develop after a prodromal period of beta-cell autoimmunity, this study has examined whether 64,000 Mr antibodies could be detected in 14 individuals who subsequently developed IDDM and five first degree relatives who have indications of altered beta-cell function. Sera were screened by immunoprecipitation on total detergent lysates of human islets and positive sera retested on membrane protein preparations. Antibodies to the 64,000 Mr membrane protein were consistently detected in 11/14 IDDM patients, and in all 5 first degree relatives. 10 IDDM patients were already positive in the first samples, obtained 4-91 mo before the clinical onset of IDDM, whereas 1 patient progressed to a high 64,000 Mr immunoreactivity, at a time where a commencement of a decline in beta-cell function was detected. 64,000 Mr antibodies were detected before islet cell cytoplasmic antibodies (ICCA) in two patients. In the control groups of 21 healthy individuals, 36 patients with diseases of the thyroid and 5 SLE patients, the 64,000 Mr antibodies were detected in only one individual, who was a healthy sibling to an IDDM patient. These results suggest that antibodies against the Mr 64,000 human islet protein are an early marker of beta-cell autoimmunity and may be useful to predict a later development of IDDM.
653 a Adolescent
653 a Adult
653 a Autoantibodies/immunology
653 a Autoantigens/immunology
653 a Cytoplasm/immunology
653 a Diabetes Mellitus, Type 1/genetics
653 a Female
653 a Humans
653 a Immunosorbent Techniques
653 a Islets of Langerhans/immunology
653 a Lupus Erythematosus, Systemic/immunology
653 a Male
653 a Membrane Proteins/immunology
653 a Middle Aged
653 a Molecular Weight
653 a Prospective Studies
653 a Thyroid Diseases/immunology
7001 a Landin, Mu Lund University,Lunds universitet,Medicin/akutsjukvård, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Diabetes lab,Forskargrupper vid Lunds universitet,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)med-mla
7001 a Kristensen, J K4 aut
7001 a Srikanta, S4 aut
7001 a Bruining, G J4 aut
7001 a Mandrup-Poulsen, T4 aut
7001 a de Beaufort, C4 aut
7001 a Soeldner, J S4 aut
7001 a Eisenbarth, G4 aut
7001 a Lindgren, F4 aut
7001 a Sundquist, Göran4 aut
7001 a Lernmark, Akeu Hagedorn Research Institute4 aut0 (Swepub:lu)endo-ale
7102 a Medicin/akutsjukvård, Lundb Sektion II4 org
7730 t Journal of Clinical Investigationg 79:3, s. 34-926q 79:3<34-926x 0021-9738
8564 u http://dx.doi.org/10.1172/JCI112903y FULLTEXT
8564 8u https://lup.lub.lu.se/record/366fb20e-1e1d-4e95-b91a-f7350d6d1b0e
8564 8u https://doi.org/10.1172/JCI112903

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