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Neurocognitive impa...
Neurocognitive impairment, employment, and social status in radiotherapy-treated adult survivors of childhood brain tumors
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- Remes, Tiina M. (författare)
- Oulu Univ Hosp, PEDEGO Res Unit, Dept Pediat & Adolescence, Oulu, Finland; Oulu Univ Hosp, Med Res Ctr, Oulu, Finland; Univ Oulu, Oulu, Finland; Univ Helsinki, Childrens Hosp, Dept Child Neurol, Helsinki, Finland; Helsinki Univ Hosp, Helsinki, Finland
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- Hovén, Emma (författare)
- Karolinska Institutet
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- Ritari, Niina (författare)
- Univ Helsinki, Childrens Hosp, Dept Child Neurol, Helsinki, Finland; Helsinki Univ Hosp, Helsinki, Finland
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- Pohjasniemi, Heli (författare)
- Oulu Univ Hosp, PEDEGO Res Unit, Dept Pediat & Adolescence, Oulu, Finland; Oulu Univ Hosp, Med Res Ctr, Oulu, Finland; Univ Oulu, Oulu, Finland
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- Puosi, Riina (författare)
- Univ Helsinki, Childrens Hosp, Dept Child Neurol, Helsinki, Finland; Helsinki Univ Hosp, Helsinki, Finland
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- Arikoski, Pekka M. (författare)
- Univ Eastern Finland, Kuopio Univ Hosp, Dept Pediat & Adolescence, Kuopio, Finland
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- Arola, Mikko O. (författare)
- Tampere Univ Hosp, Dept Pediat, Tampere, Finland; Univ Tampere, Tampere, Finland
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- Lähteenmäki, Päivi M. (författare)
- Turku Univ Hosp, Dept Pediat & Adolescent Med, Turku, Finland; Turku Univ, Turku, Finland
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- Lönnqvist, Tuula R. I. (författare)
- Univ Helsinki, Childrens Hosp, Dept Child Neurol, Helsinki, Finland; Helsinki Univ Hosp, Helsinki, Finland
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- Ojaniemi, Marja K. (författare)
- Oulu Univ Hosp, PEDEGO Res Unit, Dept Pediat & Adolescence, Oulu, Finland; Oulu Univ Hosp, Med Res Ctr, Oulu, Finland; Univ Oulu, Oulu, Finland
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- Riikonen, V. Pekka (författare)
- Univ Eastern Finland, Kuopio Univ Hosp, Dept Pediat & Adolescence, Kuopio, Finland
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- Sirkiä, Kirsti H. (författare)
- Helsinki Univ Hosp, Helsinki, Finland; Univ Helsinki, Dept Pediat & Adolescence, Helsinki, Finland
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- Winqvist, Satu (författare)
- Oulu Univ Hosp, Dept Neurol, Oulu, Finland
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- Rantala, Heikki M. J. (författare)
- Oulu Univ Hosp, PEDEGO Res Unit, Dept Pediat & Adolescence, Oulu, Finland; Oulu Univ Hosp, Med Res Ctr, Oulu, Finland; Univ Oulu, Oulu, Finland
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- Harila, Marika (författare)
- Oulu Univ Hosp, Dept Neurol, Oulu, Finland
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- Harila-Saari, Arja H. (författare)
- Uppsala universitet,Barnneurologi/Barnonkologi
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(creator_code:org_t)
- 2021-01-22
- 2021
- Engelska.
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Ingår i: Neuro-Oncology Practice. - : Oxford University Press. - 2054-2577 .- 2054-2585. ; 8:3, s. 266-277
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- BackgroundLittle is known of the cognitive functions, employment, and social status in adult survivors of childhood brain tumor (BT). We aimed to determine the long-term neurocognitive profile of radiotherapy-treated adult survivors of childhood BT and the relationship between cognitive functions and employment and social status.MethodsNeurocognitive profiles of survivors were assessed in a Finnish national cohort of 71 radiotherapy-treated survivors of childhood BT (median follow-up time: 21 years [range: 5-33 years]) using a cross-sectional design. Neurocognitive outcomes were compared to control (n = 45) and normative values. Tumor- and treatment-related data were collected from the patient files. Information on employment and social status was gathered.ResultsSurvivors’ (median age: 27 years [range: 16-43 years]) median verbal and performance intelligence quotient (IQ) was 90 (range: 49-121) and 87 (range: 43-119), respectively. The cognitive domains with the greatest impairment were executive functions (median z score, −3.5 SD [range: −25.0 to 1.3 SD]), and processing speed and attention (median z score, −2.5 SD [range: −24.9 to 0.5 SD]). Executive functions were associated with employment, educational level, living independently, having an intimate relationship, and having a driving license. Processing speed and attention were related to educational level, living independently, having an intimate relationship, and having a driving license. Performance IQ was associated with educational level and employment status. Working memory was associated with educational level and living independently.ConclusionsRadiotherapy-treated adult survivors of childhood BT experience significant neurocognitive impairment, which is associated with difficulties related to employment and social status.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- brain tumor
- employment
- neurocognitive impairment
- radiation
- social status
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Remes, Tiina M.
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Hovén, Emma
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Ritari, Niina
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Pohjasniemi, Hel ...
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Puosi, Riina
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Arikoski, Pekka ...
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visa fler...
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Arola, Mikko O.
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Lähteenmäki, Päi ...
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Lönnqvist, Tuula ...
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Ojaniemi, Marja ...
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Riikonen, V. Pek ...
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Sirkiä, Kirsti H ...
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Winqvist, Satu
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Rantala, Heikki ...
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Harila, Marika
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Harila-Saari, Ar ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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Neuro-Oncology P ...
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet