WFRF:(Raherison C.)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04201naa a2200541 4500 | |
| 001 | oai:DiVA.org:uu-311302 | |
| 003 | SwePub | |
| 008 | 161222s2017 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3113022 URI |
| 024 | 7 | a https://doi.org/10.1136/thoraxjnl-2015-2081542 DOI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Campbell, B4 aut |
| 245 | 1 0 | a The effects of growing up on a farm on adult lung function and allergic phenotypes :b an international population-based study |
| 264 | c 2016-09-26 | |
| 264 | 1 | b BMJ,c 2017 |
| 338 | a print2 rdacarrier | |
| 520 | a RATIONALE: Evidence has suggested that exposure to environmental or microbial biodiversity in early life may impact subsequent lung function and allergic disease risk.OBJECTIVES: To investigate the influence of childhood living environment and biodiversity indicators on atopy, asthma and lung function in adulthood.METHODS AND MEASUREMENTS: The European Community Respiratory Health Survey II investigated ∼10 201 participants aged 26-54 years from 14 countries, including participants' place of upbringing (farm, rural environment or inner city) before age 5 years. A 'biodiversity score' was created based on childhood exposure to cats, dogs, day care, bedroom sharing and older siblings. Associations with lung function, bronchial hyper-responsiveness (BHR), allergic sensitisation, asthma and rhinitis were analysed.MAIN RESULTS: As compared with a city upbringing, those with early-life farm exposure had less atopic sensitisation (adjusted OR 0.46, 95% CI 0.37 to 0.58), atopic BHR (0.54 (0.35 to 0.83)), atopic asthma (0.47 (0.28 to 0.81)) and atopic rhinitis (0.43 (0.32 to 0.57)), but not non-atopic outcomes. Less pronounced protective effects were observed for rural environment exposures. Women with a farm upbringing had higher FEV1 (adjusted difference 110 mL (64 to 157)), independent of sensitisation and asthma. In an inner city environment, a higher biodiversity score was related to less allergic sensitisation.CONCLUSIONS: This is the first study to report beneficial effects of growing up on a farm on adult FEV1. Our study confirmed the beneficial effects of early farm life on sensitisation, asthma and rhinitis, and found a similar association for BHR. In persons with an urban upbringing, a higher biodiversity score predicted less allergic sensitisation, but to a lesser magnitude than a childhood farm environment. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Lungmedicin och allergi0 (SwePub)302192 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Respiratory Medicine and Allergy0 (SwePub)302192 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng |
| 700 | 1 | a Raherison, C4 aut |
| 700 | 1 | a Lodge, C J4 aut |
| 700 | 1 | a Lowe, A J4 aut |
| 700 | 1 | a Gislason, T4 aut |
| 700 | 1 | a Heinrich, J4 aut |
| 700 | 1 | a Sunyer, J4 aut |
| 700 | 1 | a Gómez Real, F4 aut |
| 700 | 1 | a Norbäck, Danu Uppsala universitet,Arbets- och miljömedicin4 aut0 (Swepub:uu)dagnorba |
| 700 | 1 | a Matheson, M C4 aut |
| 700 | 1 | a Wjst, M4 aut |
| 700 | 1 | a Dratva, J4 aut |
| 700 | 1 | a de Marco, R4 aut |
| 700 | 1 | a Jarvis, D4 aut |
| 700 | 1 | a Schlünssen, V4 aut |
| 700 | 1 | a Janson, Christeru Uppsala universitet,Lungmedicin och allergologi4 aut0 (Swepub:uu)chrisjn |
| 700 | 1 | a Leynaert, B4 aut |
| 700 | 1 | a Svanes, C4 aut |
| 700 | 1 | a Dharmage, S C4 aut |
| 710 | 2 | a Uppsala universitetb Arbets- och miljömedicin4 org |
| 773 | 0 | t Thoraxd : BMJg 72:3, s. 236-244q 72:3<236-244x 0040-6376x 1468-3296 |
| 856 | 4 | u https://thorax.bmj.com/content/thoraxjnl/72/3/236.full.pdf |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-311302 |
| 856 | 4 8 | u https://doi.org/10.1136/thoraxjnl-2015-208154 |
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