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Sökning: WFRF:(Rickert Martin E.) > (2013) > Preterm birth and m...

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FältnamnIndikatorerMetadata
00005401naa a2200433 4500
001oai:DiVA.org:oru-54578
003SwePub
008170112s2013 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:127994696
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-545782 URI
0247 a https://doi.org/10.1001/jamapsychiatry.2013.21072 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1279946962 URI
040 a (SwePub)orud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a D'Onofrio, Brian M.u Department of Psychological and Brain Sciences, Indiana University, Bloomington, United States4 aut
2451 0a Preterm birth and mortality and morbidity :b a population-based quasi-experimental study
264 1a Chicago, USA :b American Medical Association,c 2013
338 a print2 rdacarrier
500 a Funding Agencies:National Institute of Child Health and Human Development National Institute of Mental Health Swedish Prison and Probation Services 
520 a Importance: Preterm birth is associated with increased mortality and morbidity. However, previous studies have been unable to rigorously examine whether confounding factors cause these associations rather than the harmful effects of being born preterm.Objective: To estimate the extent to which the associations between early gestational age and offspring mortality and morbidity are the result of confounding factors by using a quasi-experimental design, the sibling-comparison approach, and by controlling for statistical covariates that varied within families.Design, setting and participants: A population-based cohort study, combining Swedish registries to identify all individuals born in Sweden from 1973 to 2008 (3,300,708 offspring of 1,736,735 mothers) and link them with multiple outcomes.Main outcomes and measures: Offspring mortality (during infancy and throughout young adulthood) and psychiatric (psychotic or bipolar disorder, autism, attention-deficit/hyperactivity disorder, suicide attempts, substance use, and criminality), academic (failing grades and educational attainment), and social (partnering, parenthood, low income, and social welfare benefits) outcomes through 2009.Results: In the population, there was a dose-response relationship between early gestation and the outcome measures. For example, extreme preterm birth (23-27 weeks of gestation) was associated with infant mortality (odds ratio, 288.1; 95% CI, 271.7-305.5), autism (hazard ratio [HR], 3.2; 95% CI, 2.6-4.0), low educational attainment (HR, 1.7; 1.5-2.0), and social welfare benefits (HR, 1.3; 1.2-1.5) compared with offspring born at term. The associations between early gestation and mortality and psychiatric morbidity generally were robust when comparing differentially exposed siblings and controlling for statistical covariates, whereas the associations with academic and some social problems were greatly or completely attenuated in the fixed-effects models.Conclusions and relevance: The mechanisms responsible for the associations between preterm birth and mortality and morbidity are outcome-specific. Associations between preterm birth and mortality and psychiatric morbidity are largely independent of shared familial confounds and measured covariates, consistent with a causal inference. However, some associations, particularly predicting suicide attempt, educational attainment, and social welfare benefits, are the result of confounding factors. The findings emphasize the importance of both reducing preterm birth and providing wraparound services to all siblings in families with an offspring born preterm.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng
7001 a Class, Quetzal A.u Department of Psychological and Brain Sciences, Indiana University, Bloomington, United States4 aut
7001 a Rickert, Martin E.u Department of Psychological and Brain Sciences, Indiana University, Bloomington, United States4 aut
7001 a Larsson, Henrik,d 1975-u Karolinska Institutet4 aut0 (Swepub:oru)hiln
7001 a Långström, Niklasu Karolinska Institutet4 aut
7001 a Lichtenstein, Paulu Karolinska Institutet4 aut
7102 a Karolinska Institutetb Department of Psychological and Brain Sciences, Indiana University, Bloomington, United States4 org
7730 t JAMA psychiatryd Chicago, USA : American Medical Associationg 70:11, s. 1231-1240q 70:11<1231-1240x 2168-6238x 2168-622X
8564 u https://doi.org/10.1001/jamapsychiatry.2013.2107y Fulltext
8564 u https://jamanetwork.com/journals/jamapsychiatry/articlepdf/1743009/yoi130024.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-54578
8564 8u https://doi.org/10.1001/jamapsychiatry.2013.2107
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:127994696

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