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Positron emission tomography with [18F]flutemetamol and [11C]PiB for in vivo detection of cerebral cortical amyloid in normal pressure hydrocephalus patients.
- Leinonen, V (author)
- Rinne, J O (author)
- Virtanen, K A (author)
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- Eskola, O (author)
- Rummukainen, J (author)
- Huttunen, J (author)
- von Und Zu Fraunberg, M (author)
- Nerg, O (author)
- Koivisto, A M (author)
- Rinne, J (author)
- Jääskeläinen, J E (author)
- Buckley, C (author)
- Smith, A (author)
- Jones, P A (author)
- Sherwin, P (author)
- Farrar, G (author)
- McLain, R (author)
- Kailajärvi, M (author)
- Grachev, I D (author)
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- (creator_code:org_t)
- 2013-02-11
- 2013
- English.
- In: European Journal of Neurology. - : Wiley. - 1351-5101 .- 1468-1331. ; 20:7, s. 1043-52
- Journal article (peer-reviewed)
Abstract
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- BACKGROUND AND PURPOSE: This study determined the correlation between uptake of the amyloid positron emission tomography (PET) imaging agent [(18) F]flutemetamol and amyloid-β measured by immunohistochemical and histochemical staining in a frontal cortical biopsy.METHODS: Fifteen patients with possible normal pressure hydrocephalus (NPH) and previous brain biopsy obtained during intracranial pressure monitoring underwent [18F]flutemetamol PET. Seven of these patients also underwent [11C] Pittsburgh compound B (PiB) PET. [18F]Flutemetamol and [11C]PiB uptake was quantified using standardized uptake value ratio (SUVR) with the cerebellar cortex as a reference region. Tissue amyloid-β was evaluated using the monoclonal antibody 4G8, Thioflavin-S and Bielschowsky silver stain.RESULTS: [18F]Flutemetamol and [11C]PiB SUVRs correlated with biopsy specimen amyloid-β levels contralateral (r = 0.86, P < 0.0001; r = 0.96, P = 0.0008) and ipsilateral (r = 0.82, P = 0.0002; r = 0.87, P = 0.01) to the biopsy site. Association between cortical composite [(18) F]flutemetamol SUVRs and [11C]PiB SUVRs was highly significant (r = 0.97, P = 0.0003).CONCLUSIONS: [18F]Flutemetamol detects brain amyloid-β in vivo with moderate to high sensitivity and high specificity. This agent, therefore, represents a valuable new tool to study and verify the presence of amyloid-β pathology, both in patients with possible NPH and among the wider population.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
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- Leinonen, V
- Rinne, J O
- Virtanen, K A
- Eskola, O
- Rummukainen, J
- Huttunen, J
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- von Und Zu Fraun ...
- Nerg, O
- Koivisto, A M
- Rinne, J
- Jääskeläinen, J ...
- Buckley, C
- Smith, A
- Jones, P A
- Sherwin, P
- Farrar, G
- McLain, R
- Kailajärvi, M
- Heurling, Kersti ...
- Grachev, I D
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