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Sökning: WFRF:(Robinson Jody) > (2008) > Somatic mutations a...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 05878naa a2201357 4500 | |
| 001 | oai:DiVA.org:uu-100853 | |
| 003 | SwePub | |
| 008 | 090408s2008 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1008532 URI |
| 024 | 7 | a https://doi.org/10.1038/nature074232 DOI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Ding, Li4 aut |
| 245 | 1 0 | a Somatic mutations affect key pathways in lung adenocarcinoma |
| 264 | 1 | b Springer Science and Business Media LLC,c 2008 |
| 338 | a print2 rdacarrier | |
| 520 | a Determining the genetic basis of cancer requires comprehensive analyses of large collections of histopathologically well-classified primary tumours. Here we report the results of a collaborative study to discover somatic mutations in 188 human lung adenocarcinomas. DNA sequencing of 623 genes with known or potential relationships to cancer revealed more than 1,000 somatic mutations across the samples. Our analysis identified 26 genes that are mutated at significantly high frequencies and thus are probably involved in carcinogenesis. The frequently mutated genes include tyrosine kinases, among them the EGFR homologue ERBB4; multiple ephrin receptor genes, notably EPHA3; vascular endothelial growth factor receptor KDR; and NTRK genes. These data provide evidence of somatic mutations in primary lung adenocarcinoma for several tumour suppressor genes involved in other cancers--including NF1, APC, RB1 and ATM--and for sequence changes in PTPRD as well as the frequently deleted gene LRP1B. The observed mutational profiles correlate with clinical features, smoking status and DNA repair defects. These results are reinforced by data integration including single nucleotide polymorphism array and gene expression array. Our findings shed further light on several important signalling pathways involved in lung adenocarcinoma, and suggest new molecular targets for treatment. | |
| 653 | a MEDICINE | |
| 653 | a MEDICIN | |
| 700 | 1 | a Getz, Gad4 aut |
| 700 | 1 | a Wheeler, David A4 aut |
| 700 | 1 | a Mardis, Elaine R4 aut |
| 700 | 1 | a McLellan, Michael D4 aut |
| 700 | 1 | a Cibulskis, Kristian4 aut |
| 700 | 1 | a Sougnez, Carrie4 aut |
| 700 | 1 | a Greulich, Heidi4 aut |
| 700 | 1 | a Muzny, Donna M4 aut |
| 700 | 1 | a Morgan, Margaret B4 aut |
| 700 | 1 | a Fulton, Lucinda4 aut |
| 700 | 1 | a Fulton, Robert S4 aut |
| 700 | 1 | a Zhang, Qunyuan4 aut |
| 700 | 1 | a Wendl, Michael C4 aut |
| 700 | 1 | a Lawrence, Michael S4 aut |
| 700 | 1 | a Larson, David E4 aut |
| 700 | 1 | a Chen, Ken4 aut |
| 700 | 1 | a Dooling, David J4 aut |
| 700 | 1 | a Sabo, Aniko4 aut |
| 700 | 1 | a Hawes, Alicia C4 aut |
| 700 | 1 | a Shen, Hua4 aut |
| 700 | 1 | a Jhangiani, Shalini N4 aut |
| 700 | 1 | a Lewis, Lora R4 aut |
| 700 | 1 | a Hall, Otis4 aut |
| 700 | 1 | a Zhu, Yiming4 aut |
| 700 | 1 | a Mathew, Tittu4 aut |
| 700 | 1 | a Ren, Yanru4 aut |
| 700 | 1 | a Yao, Jiqiang4 aut |
| 700 | 1 | a Scherer, Steven E4 aut |
| 700 | 1 | a Clerc, Kerstin4 aut |
| 700 | 1 | a Metcalf, Ginger A4 aut |
| 700 | 1 | a Ng, Brian4 aut |
| 700 | 1 | a Milosavljevic, Aleksandar4 aut |
| 700 | 1 | a Gonzalez-Garay, Manuel L4 aut |
| 700 | 1 | a Osborne, John R4 aut |
| 700 | 1 | a Meyer, Rick4 aut |
| 700 | 1 | a Shi, Xiaoqi4 aut |
| 700 | 1 | a Tang, Yuzhu4 aut |
| 700 | 1 | a Koboldt, Daniel C4 aut |
| 700 | 1 | a Lin, Ling4 aut |
| 700 | 1 | a Abbott, Rachel4 aut |
| 700 | 1 | a Miner, Tracie L4 aut |
| 700 | 1 | a Pohl, Craig4 aut |
| 700 | 1 | a Fewell, Ginger4 aut |
| 700 | 1 | a Haipek, Carrie4 aut |
| 700 | 1 | a Schmidt, Heather4 aut |
| 700 | 1 | a Dunford-Shore, Brian H4 aut |
| 700 | 1 | a Kraja, Aldi4 aut |
| 700 | 1 | a Crosby, Seth D4 aut |
| 700 | 1 | a Sawyer, Christopher S4 aut |
| 700 | 1 | a Vickery, Tammi4 aut |
| 700 | 1 | a Sander, Sacha4 aut |
| 700 | 1 | a Robinson, Jody4 aut |
| 700 | 1 | a Winckler, Wendy4 aut |
| 700 | 1 | a Baldwin, Jennifer4 aut |
| 700 | 1 | a Chirieac, Lucian R4 aut |
| 700 | 1 | a Dutt, Amit4 aut |
| 700 | 1 | a Fennell, Tim4 aut |
| 700 | 1 | a Hanna, Megan4 aut |
| 700 | 1 | a Johnson, Bruce E4 aut |
| 700 | 1 | a Onofrio, Robert C4 aut |
| 700 | 1 | a Thomas, Roman K4 aut |
| 700 | 1 | a Tonon, Giovanni4 aut |
| 700 | 1 | a Weir, Barbara A4 aut |
| 700 | 1 | a Zhao, Xiaojun4 aut |
| 700 | 1 | a Ziaugra, Liuda4 aut |
| 700 | 1 | a Zody, Michael C.u Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi4 aut0 (Swepub:uu)miczo266 |
| 700 | 1 | a Giordano, Thomas4 aut |
| 700 | 1 | a Orringer, Mark B4 aut |
| 700 | 1 | a Roth, Jack A4 aut |
| 700 | 1 | a Spitz, Margaret R4 aut |
| 700 | 1 | a Wistuba, Ignacio I4 aut |
| 700 | 1 | a Ozenberger, Bradley4 aut |
| 700 | 1 | a Good, Peter J4 aut |
| 700 | 1 | a Chang, Andrew C4 aut |
| 700 | 1 | a Beer, David G4 aut |
| 700 | 1 | a Watson, Mark A4 aut |
| 700 | 1 | a Ladanyi, Marc4 aut |
| 700 | 1 | a Broderick, Stephen4 aut |
| 700 | 1 | a Yoshizawa, Akihiko4 aut |
| 700 | 1 | a Travis, William D4 aut |
| 700 | 1 | a Pao, William4 aut |
| 700 | 1 | a Province, Michael A4 aut |
| 700 | 1 | a Weinstock, George M4 aut |
| 700 | 1 | a Varmus, Harold E4 aut |
| 700 | 1 | a Gabriel, Stacey B4 aut |
| 700 | 1 | a Lander, Eric S4 aut |
| 700 | 1 | a Gibbs, Richard A4 aut |
| 700 | 1 | a Meyerson, Matthew4 aut |
| 700 | 1 | a Wilson, Richard K4 aut |
| 710 | 2 | a Uppsala universitetb Institutionen för medicinsk biokemi och mikrobiologi4 org |
| 773 | 0 | t Natured : Springer Science and Business Media LLCg 455:7216, s. 1069-1075q 455:7216<1069-1075x 0028-0836x 1476-4687 |
| 856 | 4 | u https://www.nature.com/articles/nature07423.pdf |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-100853 |
| 856 | 4 8 | u https://doi.org/10.1038/nature07423 |
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- Ding, Li
- Getz, Gad
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- Greulich, Heidi
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- Wendl, Michael C
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- Chen, Ken
- Dooling, David J
- Sabo, Aniko
- Hawes, Alicia C
- Shen, Hua
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- Hall, Otis
- Zhu, Yiming
- Mathew, Tittu
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- Meyer, Rick
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- Abbott, Rachel
- Miner, Tracie L
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