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Surgical treatment of peri-implantitis with or without a deproteinized bovine bone mineral and a native bilayer collagen membrane : A randomized clinical trial
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- Renvert, Stefan (author)
- Blekinge Tekniska Högskola,Högskolan Kristianstad,Forskningsmiljön Oral Hälsa - Allmänhälsa - Livskvalitet (OHAL),Avdelningen för oral hälsa,Irland, HongKong & Blekinge Tekniska Högskola,Institutionen för hälsa
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- Giovannoli, Jean-Louis (author)
- Frankrike,University of Corsica, FRA
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- Roos-Jansåker, Ann Marie (author)
- Public Dental Services, Karlskrona
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- Rinke, Sven (author)
- Tyskland,University Medical Center, Goettingen, DEU
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- Roos-Jansåker, Ann-Marie (author)
- Public Dental Services, Karlskrona, SWE
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(creator_code:org_t)
- John Wiley and Sons Inc, 2021
- 2021
- English.
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In: Journal of Clinical Periodontology. - : John Wiley and Sons Inc. - 0303-6979 .- 1600-051X. ; 48:10, s. 1312-1321
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Abstract
Subject headings
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- AIM: To assess whether the use of deproteinized bovine bone mineral (DBBM) and native bilayer collagen membrane (NBCM) improved healing of peri-implantitis-related bone defects at 12 months.MATERIALS AND METHODS: In a multicentre randomized clinical trial, 32 individuals received surgical debridement (CG), and 34 adjunct use of DBBM and NBCM (TG). Radiographic defect fill (RDF), probing pocket depth (PPD), bleeding on probing (BOP) suppuration (SUP), recession (REC), cytokines (IL-1β, IL-1ra, IL-6, IL-8, IL-12, IP10, PDGF-BB, TNF-α, VEGF), and patient-reported outcomes (PROs) were evaluated at 3, 6, 9 and 12 months.RESULTS: RDF at deepest site amounted 2.7 ± 1.3 mm in TG and 1.4 ± 1.2 mm in CG (p < 0.0001). PPD was reduced by 1.9 mm in TG and 2.3 mm in CG (p =0.5783). There were no significant differences between groups regarding reductions of BOP, SUP, REC, cytokines levels, or OHIP 14 scores at 12 months. Successful treatment (RDF ≥1.0 mm, PPD ≤5 mm, ≤1/4 site with BOP grade 1, no SUP) were identified in 32% in TG and 21 % in CG.CONCLUSIONS: DBBM and NBCM resulted in significantly more RDF than debridement alone. No difference was found in any clinical parameters or PROs between groups.
Subject headings
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- bone augmentation
- bone substitute
- deproteinized bovine bone mineral
- native bilayer collagen membrane
- peri-implantitis
- surgical treatment
Publication and Content Type
- ref (subject category)
- art (subject category)