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Risk of specific ca...
Risk of specific cardiovascular diseases in obsessive-compulsive disorder
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- Isomura, Kayoko (författare)
- Karolinska Institutet,Karolinska Inst, Dept Clin Neurosci, Ctr Psychiat Res, Stockholm, Sweden; Reg Stockholm, Stockholm Hlth Care Serv, Stockholm, Sweden
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- Sidorchuk, Anna (författare)
- Karolinska Institutet,Karolinska Inst, Dept Clin Neurosci, Ctr Psychiat Res, Stockholm, Sweden; Reg Stockholm, Stockholm Hlth Care Serv, Stockholm, Sweden
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- Brander, Gustaf (författare)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Karolinska Inst, Dept Clin Neurosci, Ctr Psychiat Res, Stockholm, Sweden; Reg Stockholm, Stockholm Hlth Care Serv, Stockholm, Sweden
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- Jernberg, Tomas (författare)
- Karolinska Institutet,Danderyd Hosp, Dept Clin Sci, Stockholm, Sweden
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- Rück, Andreas (författare)
- Karolinska Institutet,Karolinska Univ Hosp, Dept Cardiol, Stockholm, Sweden
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- Song, Huan (författare)
- West China Biomedical Big Data Centre, West China Hospital, Sichuan University, Chengdu, China; Center of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavík, Iceland; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden,Sichuan Univ, West China Hosp, West China Biomed Big Data Ctr, Chengdu, Peoples R China; Univ Iceland, Ctr Publ Hlth Sci, Fac Med, Reykjavik, Iceland; Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden
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- Valdimarsdóttir, Unnur A. (författare)
- Karolinska Institutet,Univ Iceland, Ctr Publ Hlth Sci, Fac Med, Reykjavik, Iceland; Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden; Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA
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- Lichtenstein, Paul (författare)
- Karolinska Institutet,Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden
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- Larsson, Henrik, 1975- (författare)
- Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden; Örebro Univ, Sch Med Sci, Örebro, Sweden
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- Rück, Christian (författare)
- Karolinska Institutet,Karolinska Inst, Dept Clin Neurosci, Ctr Psychiat Res, Stockholm, Sweden; Reg Stockholm, Stockholm Hlth Care Serv, Stockholm, Sweden
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- Mataix-Cols, David (författare)
- Karolinska Institutet,Karolinska Inst, Dept Clin Neurosci, Ctr Psychiat Res, Stockholm, Sweden; Reg Stockholm, Stockholm Hlth Care Serv, Stockholm, Sweden
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- Fernández de la Cruz, Lorena (författare)
- Karolinska Institutet,Karolinska Inst, Dept Clin Neurosci, Ctr Psychiat Res, Stockholm, Sweden; Reg Stockholm, Stockholm Hlth Care Serv, Stockholm, Sweden
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(creator_code:org_t)
- Elsevier, 2020
- 2020
- Engelska.
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Ingår i: Journal of Psychiatric Research. - : Elsevier. - 0022-3956 .- 1879-1379. ; 135, s. 189-196
- Relaterad länk:
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Abstract
Ämnesord
Stäng
- Individuals with obsessive-compulsive disorder (OCD) may have an increased risk of cardiovascular disease (CVD), but evidence for specific types of CVD is limited. This population-based, sibling-controlled cohort study investigated the risk of specific CVD in individuals with OCD. Linking data from various Swedish population-based registers, we explored the risk of a range of CVD in a cohort of individuals diagnosed with OCD between 1973 and 2013 (n = 33,561), compared to matched (1:10) unaffected individuals (n = 335,610). Hazard ratios (HR) with 95% confidence intervals (CI) were calculated using conditional Cox proportional hazards regression models, adjusting for history of somatic diseases. To control for familial confounders, we analyzed 23,263 clusters of full siblings discordant for OCD. Individuals with psychiatric comorbidities were systematically excluded to assess the impact of these comorbidities. Over an average follow-up time of 27 years, OCD was associated with an increased risk of a broad range of CVD (adjusted HR [aHR] for any CVD = 1.25 [95% confidence interval [CI], 1.22-1.29]). These associations were strongest for the subtypes venous thrombo-embolism (aHR = 1.48 [95% CI, 1.38-1.58]) and heart failure (aHR = 1.37 [95% CI, 1.28-1.46]). When comparing OCD-exposed individuals with their non-exposed full siblings, results were largely similar. Exclusion of several groups of psychiatric comorbidities resulted in comparable results, albeit attenuated. Individuals with OCD have a moderately increased risk of CVD-related morbidity, independent from history of somatic diseases, familial confounders, and psychiatric comorbidities. The time may be ripe for the development and evaluation of lifestyle interventions to help reduce the risk of cardiovascular morbidity in OCD.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Nyckelord
- Cardiovascular disease
- Cohort study
- Morbidity
- Obsessive-compulsive disorder
- Quasi-experimental design
- Sibling comparison
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Isomura, Kayoko
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Sidorchuk, Anna
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Brander, Gustaf
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Jernberg, Tomas
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Rück, Andreas
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Song, Huan
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visa fler...
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Valdimarsdóttir, ...
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Lichtenstein, Pa ...
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Larsson, Henrik, ...
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Rück, Christian
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Mataix-Cols, Dav ...
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Fernández de la ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Psykiatri
- Artiklar i publikationen
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Journal of Psych ...
- Av lärosätet
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Örebro universitet
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Karolinska Institutet
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Uppsala universitet