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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003302naa a2200529 4500
001oai:DiVA.org:su-169092
003SwePub
008190618s2019 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1690922 URI
0247 a https://doi.org/10.1038/s41589-019-0251-42 DOI
040 a (SwePub)su
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Edgar, Rebecca J.4 aut
2451 0a Discovery of glycerol phosphate modification on streptococcal rhamnose polysaccharides
264 c 2019-04-01
264 1b Springer Science and Business Media LLC,c 2019
338 a print2 rdacarrier
520 a Cell wall glycopolymers on the surface of Gram-positive bacteria are fundamental to bacterial physiology and infection biology. Here we identify gacH, a gene in the Streptococcus pyogenes group A carbohydrate (GAC) biosynthetic cluster, in two independent transposon library screens for its ability to confer resistance to zinc and susceptibility to the bactericidal enzyme human group IIA-secreted phospholipase A(2). Subsequent structural and phylogenetic analysis of the GacH extracellular domain revealed that GacH represents an alternative class of glycerol phosphate transferase. We detected the presence of glycerol phosphate in the GAC, as well as the serotype c carbohydrate from Streptococcus mutans, which depended on the presence of the respective gacH homologs. Finally, nuclear magnetic resonance analysis of GAC confirmed that glycerol phosphate is attached to approximately 25% of the GAC N-acetylglucosamine side-chains at the C6 hydroxyl group. This previously unrecognized structural modification impacts host-pathogen interaction and has implications for vaccine design.
650 7a NATURVETENSKAPx Biologi0 (SwePub)1062 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciences0 (SwePub)1062 hsv//eng
650 7a NATURVETENSKAPx Kemi0 (SwePub)1042 hsv//swe
650 7a NATURAL SCIENCESx Chemical Sciences0 (SwePub)1042 hsv//eng
7001 a van Hensbergen, Vincent P.4 aut
7001 a Ruda, Alessandrou Stockholms universitet,Institutionen för organisk kemi4 aut0 (Swepub:su)alru3031
7001 a Turner, Andrew G.4 aut
7001 a Deng, Pan4 aut
7001 a Le Breton, Yoann4 aut
7001 a El-Sayed, Najib M.4 aut
7001 a Belew, Ashton T.4 aut
7001 a McIver, Kevin S.4 aut
7001 a McEwan, Alastair G.4 aut
7001 a Morris, Andrew J.4 aut
7001 a Lambeau, Gérard4 aut
7001 a Walker, Markj4 aut
7001 a Rush, Jeffrey S.4 aut
7001 a Korotkov, Konstantin4 aut
7001 a Widmalm, Göranu Stockholms universitet,Institutionen för organisk kemi4 aut0 (Swepub:su)gw
7001 a van Sorge, Nina M.4 aut
7001 a Korotkova, Natalia4 aut
7102 a Stockholms universitetb Institutionen för organisk kemi4 org
7730 t Nature Chemical Biologyd : Springer Science and Business Media LLCg 15:5, s. 463-+q 15:5<463-+x 1552-4450x 1552-4469
8564 u https://www.nature.com/articles/s41589-019-0251-4.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-169092
8564 8u https://doi.org/10.1038/s41589-019-0251-4

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