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Sökning: WFRF:(Sarhadi Virinder) > (2018) > Stool Microbiota Co...

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FältnamnIndikatorerMetadata
00004899naa a2200505 4500
001oai:DiVA.org:uu-370010
003SwePub
008190107s2018 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3700102 URI
0247 a https://doi.org/10.1007/s10620-018-5190-52 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Youssef, Omaru Univ Helsinki, Fac Med, Dept Pathol, Haartmaninkatu 3,POB 21, FIN-00014 Helsinki, Finland4 aut
2451 0a Stool Microbiota Composition Differs in Patients with Stomach, Colon, and Rectal Neoplasms
264 c 2018-07-11
264 1b SPRINGER,c 2018
338 a electronic2 rdacarrier
520 a BackgroundMicrobial ecosystems that inhabit the human gut form central component of our physiology and metabolism, regulating and modulating both health and disease. Changes or disturbances in the composition and activity of this gut microbiota can result in altered immunity, inflammation, and even cancer.AimTo compare the composition and diversity of gut microbiota in stool samples from patient groups based on the site of neoplasm in the gastrointestinal tract (GIT) and to assess the possible contribution of the bacterial composition to tumorigenesis.MethodsWe studied gut microbiota by16S RNA gene sequencing from stool DNA of 83 patients, who were diagnosed with different GIT neoplasms, and 13 healthy individuals.ResultsAs compared to healthy individuals, stools of patients with stomach neoplasms had elevated levels of Enterobacteriaceae, and those with rectal neoplasms had lower levels of Bifidobacteriaceae. Lower abundance of Lactobacillaceae was seen in patients with colon neoplasms. Abundance of Lactobacillaceae was higher in stools of GIT patients sampled after cancer treatment compared to samples collected before start of any treatment. In addition to site-specific differences, higher abundances of Ruminococcus, Subdoligranulum and lower abundances of Lachnoclostridium and Oscillibacter were observed in overall GIT neoplasms as compared to healthy controlsConclusionOur study demonstrates that the alterations in gut microbiota vary according to the site of GIT neoplasm. The observed lower abundance of two common families, Lactobacillaceae and Bifidobacteriaceae, and the increased abundance of Enterobacteriaceae could provide indicators of compromised gut health and potentially facilitate GIT disease monitoring.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Gastroenterologi0 (SwePub)302132 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Gastroenterology and Hepatology0 (SwePub)302132 hsv//eng
653 a Fecal microbiota
653 a Gastrointestinal neoplasms
653 a 16S rRNA gene sequencing
7001 a Lahti, Leou Univ Turku, Dept Math & Stat, Turku 20014, Finland4 aut
7001 a Kokkola, Artou Univ Cent Hosp Helsinki, HUCH Gastrointestinal Clin, Helsinki 00290, Finland4 aut
7001 a Karla, Tiinau Thermo Fisher Sci Co, Vantaa 01620, Finland4 aut
7001 a Tikkanen, Miljau Thermo Fisher Sci Co, Vantaa 01620, Finland4 aut
7001 a Ehsan, Homau Univ Helsinki, Fac Med, Dept Pathol, Haartmaninkatu 3,POB 21, FIN-00014 Helsinki, Finland4 aut
7001 a Carpelan-Holmstrom, Monikau Univ Cent Hosp Helsinki, HUCH Gastrointestinal Clin, Helsinki 00290, Finland4 aut
7001 a Koskensalo, Seljau Univ Cent Hosp Helsinki, HUCH Gastrointestinal Clin, Helsinki 00290, Finland4 aut
7001 a Bohling, Tomu Univ Helsinki, Dept Pathol, FIN-00014 Helsinki, Finland;Helsinki Univ Hosp, HUSLAB, Helsinki 00014, Finland4 aut
7001 a Rautelin, Hilpiu Uppsala universitet,Klinisk mikrobiologi4 aut0 (Swepub:uu)hilra999
7001 a Puolakkainen, Pauliu Univ Cent Hosp Helsinki, HUCH Gastrointestinal Clin, Helsinki 00290, Finland4 aut
7001 a Knuutila, Sakariu Univ Helsinki, Fac Med, Dept Pathol, Haartmaninkatu 3,POB 21, FIN-00014 Helsinki, Finland4 aut
7001 a Sarhadi, Virinderu Univ Helsinki, Fac Med, Dept Pathol, Haartmaninkatu 3,POB 21, FIN-00014 Helsinki, Finland4 aut
7102 a Univ Helsinki, Fac Med, Dept Pathol, Haartmaninkatu 3,POB 21, FIN-00014 Helsinki, Finlandb Univ Turku, Dept Math & Stat, Turku 20014, Finland4 org
7730 t Digestive Diseases and Sciencesd : SPRINGERg 63:11, s. 2950-2958q 63:11<2950-2958x 0163-2116x 1573-2568
8564 u https://doi.org/10.1007/s10620-018-5190-5y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1275957/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://link.springer.com/content/pdf/10.1007/s10620-018-5190-5.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-370010
8564 8u https://doi.org/10.1007/s10620-018-5190-5

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