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Sökning: WFRF:(Savva A) > (2005-2009) > Monosomy 7 and dele...

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FältnamnIndikatorerMetadata
00004084naa a2200781 4500
001oai:DiVA.org:umu-7073
003SwePub
008080112s2007 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-70732 URI
040 a (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Hasle, Henrik4 aut
2451 0a Monosomy 7 and deletion 7q in children and adolescents with acute myeloid leukemia :b an international retrospective study.
264 1c 2007
338 a print2 rdacarrier
520 a Monosomy 7 (-7) and deletion 7q \del(7q)] are rare in childhood acute myeloid leukemia (AML). We retrospectively collected data on 258 children with AML or refractory anemia with excess blasts in transformation (RAEB-T) and -7 or del(7q) with or without other cytogenetic aberrations \+/- other]. Karyotypes included -7 (n = 90), -7 other (n = 82), del(7q) (n = 21), and del(7q) other (n = 65). Complete remission (CR) was achieved in fewer patients with -7 +/- other compared with del(7q) +/- other (61% versus 89%, P < .001). Overall, the 5-year survival rate was 39% (SE, 3%). Survival was superior in del(7q) +/- other compared with -7 +/- other (51% versus 30%, P < .01). Cytogenetic aberrations considered favorable in AML \t(8;21)(q22;q22), inv(16)(p13q22), t(15;17)(q22;q21), t(9;11)(p22;q23)] (n = 24) were strongly associated with del(7q) and a higher 5-year survival rate compared with del(7q) without favorable cytogenetics (75% versus 46%, P = .03). Patients with -7 and inv(3),-5/del(5q), or + 21 had a 5-year survival rate of 5%. Stem cell transplantation analyzed as a time-dependent variable had no impact on overall survival. However, patients not achieving CR had a 31% survival rate after stem cell transplantation. Childhood AML with chromosome 7 aberrations represents a heterogeneous group of disorders with additional cytogenetic aberrations having a major prognostic impact which should be reflected in future risk-group stratification.
653 a Adolescent
653 a Child
653 a Chromosome Aberrations
653 a Chromosomes; Human; Pair 7
653 a Female
653 a Gene Deletion
653 a Humans
653 a International Cooperation
653 a Leukemia; Myeloid; Acute/*genetics/*mortality
653 a Male
653 a Monosomy
653 a Remission Induction
653 a Retrospective Studies
653 a Stem Cell Transplantation
653 a Translocation; Genetic
7001 a Alonzo, Todd A4 aut
7001 a Auvrignon, Anne4 aut
7001 a Behar, Catherine4 aut
7001 a Chang, Myron4 aut
7001 a Creutzig, Ursula4 aut
7001 a Fischer, Alexandra4 aut
7001 a Forestier, Eriku Umeå universitet,Pediatrik4 aut
7001 a Fynn, Alcira4 aut
7001 a Haas, Oskar A4 aut
7001 a Harbott, Jochen4 aut
7001 a Harrison, Christine J4 aut
7001 a Heerema, Nyla A4 aut
7001 a van den Heuvel-Eibrink, Marry M4 aut
7001 a Kaspers, Gertjan J L4 aut
7001 a Locatelli, Franco4 aut
7001 a Noellke, Peter4 aut
7001 a Polychronopoulou, Sophia4 aut
7001 a Ravindranath, Yaddanapudi4 aut
7001 a Razzouk, Bassem4 aut
7001 a Reinhardt, Dirk4 aut
7001 a Savva, Natalia N4 aut
7001 a Stark, Batia4 aut
7001 a Suciu, Stefan4 aut
7001 a Tsukimoto, Ichiro4 aut
7001 a Webb, David K4 aut
7001 a Wojcik, Dorora4 aut
7001 a Woods, William G4 aut
7001 a Zimmermann, Martin4 aut
7001 a Niemeyer, Charlotte M4 aut
7001 a Raimondi, Susana C4 aut
7102 a Umeå universitetb Pediatrik4 org
7730 t Bloodg 109:11, s. 4641-7q 109:11<4641-7x 0006-4971
8564 u http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=17299091&dopt=Citation
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-7073

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