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Risk of late health...
Risk of late health effects after soft-tissue sarcomas in childhood–a population-based cohort study within the Adult Life after Childhood Cancer in Scandinavia research programme
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- Norsker, Filippa Nyboe (författare)
- Danish Cancer Society
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- Boschini, Cristina (författare)
- Danish Cancer Society,University of Copenhagen
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- Rechnitzer, Catherine (författare)
- Copenhagen University Hospital
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- Holmqvist, Anna Sällfors (författare)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Sena effekter efter barncancerbehandling,Forskargrupper vid Lunds universitet,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Late effects after childhood cancer treatment,Lund University Research Groups,Skåne University Hospital
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- Tryggvadottir, Laufey (författare)
- Icelandic Cancer Registry,University of Iceland
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- Madanat-Harjuoja, Laura Maria (författare)
- Finnish Cancer Registry,Harvard University
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- Schrøder, Henrik (författare)
- Aarhus University Hospital
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- Scheike, Thomas H. (författare)
- University of Copenhagen
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- Hasle, Henrik (författare)
- Aarhus University Hospital
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- Winther, Jeanette Falck (författare)
- Aarhus University Hospital,Danish Cancer Society
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- Andersen, Klaus Kaae (författare)
- Danish Cancer Society
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(creator_code:org_t)
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- 2020
- 2020
- Engelska 11 s.
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Ingår i: Acta Oncologica. - 0284-186X. ; 59:10, s. 1-11
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Background: In the 1960s only 1/3 of children with soft-tissue sarcomas survived, however with improved treatments survival today has reached 70%. Given the previous poor survival and the rarity of soft-tissue sarcomas, the risk of somatic late effects in a large cohort of Nordic soft-tissue sarcoma survivors has not yet been assessed. Methods: In this population-based cohort study we identified 985 five-year soft-tissue sarcoma survivors in Nordic nationwide cancer registries and late effects in national hospital registries covering the period 1964–2012. Information on tumour site and radiotherapy was available for Danish and Finnish survivors (N = 531). Using disease-specific rates of first-time hospital contacts for somatic diseases in survivors and in 4,830 matched comparisons we calculated relative rates (RR) and rate differences (RD). Results: Survivors had a RR of 1.5 (95% CI 1.4–1.7) and an absolute RD of 23.5 (17.7–29.2) for a first hospital contact per 1,000 person-years. The highest risks in both relative and absolute terms were of endocrine disorders (RR = 2.5; RD = 7.6), and diseases of the nervous system (RR = 1.9; RD = 6.6), digestive organs (RR = 1.7; RD = 5.4) and urinary system (RR = 1.7; RD = 5.6). By tumour site, excess risk was lower after extremity tumours. Irradiated survivors had a 2.6 (1.2–5.9) times higher risk than non-irradiated. Conclusions: Soft-tissue sarcoma survivors have an increased risk of somatic late effects in 5 out of 10 main diagnostic groups of diseases, and the risk remains increased up to 40 years after cancer diagnosis. Risks were slightly lower for those treated for tumours in the extremities, and radiotherapy increased the risk by more than two-fold.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
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Norsker, Filippa ...
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Boschini, Cristi ...
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Rechnitzer, Cath ...
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Holmqvist, Anna ...
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Tryggvadottir, L ...
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Madanat-Harjuoja ...
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Schrøder, Henrik
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Scheike, Thomas ...
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Hasle, Henrik
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Winther, Jeanett ...
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Andersen, Klaus ...
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