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Functional metabolomics as a tool to analyze Mediator function and structure in plants

Davoine, Celine (author)
Umeå universitet,Institutionen för medicinsk kemi och biofysik
Abreu, Ilka (author)
Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för skoglig genetik och växtfysiologi,Department of Forest Genetics and Plant Physiology
Khajeh, Khalil (author)
Umeå universitet,Institutionen för medicinsk kemi och biofysik
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Blomberg, Jeanette (author)
Umeå universitet,Institutionen för medicinsk kemi och biofysik
Kidd, Brendan N. (author)
Kazan, Kemal (author)
Schenk, Peer M. (author)
Gerber, Lorenz (author)
Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för skoglig genetik och växtfysiologi,Department of Forest Genetics and Plant Physiology
Nilsson, Ove (author)
Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för skoglig genetik och växtfysiologi,Department of Forest Genetics and Plant Physiology
Moritz, Thomas (author)
Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för skoglig genetik och växtfysiologi,Department of Forest Genetics and Plant Physiology
Björklund, Stefan (author)
Umeå universitet,Institutionen för medicinsk kemi och biofysik
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 (creator_code:org_t)
 
2017-06-22
2017
English.
In: PLOS ONE. - : Public Library Science. - 1932-6203. ; 12:6
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https://umu.diva-por... (primary) (Raw object)
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Mediator is a multiprotein transcriptional co-regulator complex composed of four modules; Head, Middle, Tail, and Kinase. It conveys signals from promoter-bound transcriptional regulators to RNA polymerase II and thus plays an essential role in eukaryotic gene regulation. We describe subunit localization and activities of Mediator in Arabidopsis through metabolome and transcriptome analyses from a set of Mediator mutants. Functional metabolomic analysis based on the metabolite profiles of Mediator mutants using multivariate statistical analysis and heat-map visualization shows that different subunit mutants display distinct metabolite profiles, which cluster according to the reported localization of the corresponding subunits in yeast. Based on these results, we suggest localization of previously unassigned plant Mediator subunits to specific modules. We also describe novel roles for individual subunits in development, and demonstrate changes in gene expression patterns and specific metabolite levels in med18 and med25, which can explain their phenotypes. We find that med18 displays levels of phytoalexins normally found in wild type plants only after exposure to pathogens. Our results indicate that different Mediator subunits are involved in specific signaling pathways that control developmental processes and tolerance to pathogen infections.

Subject headings

NATURVETENSKAP  -- Biologi -- Utvecklingsbiologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Developmental Biology (hsv//eng)
NATURVETENSKAP  -- Biologi -- Genetik (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Genetics (hsv//eng)
NATURVETENSKAP  -- Annan naturvetenskap -- Övrig annan naturvetenskap (hsv//swe)
NATURAL SCIENCES  -- Other Natural Sciences -- Other Natural Sciences not elsewhere specified (hsv//eng)
NATURVETENSKAP  -- Biologi -- Annan biologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Other Biological Topics (hsv//eng)

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