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Rituximab in patients with pediatric multiple sclerosis and other demyelinating disorders of the CNS : Practical considerations
- Ghezzi, Angelo (author)
- Banwell, Brenda (author)
- Bar-Or, Amit (author)
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- Chitnis, Tanuja (author)
- Dale, Russell C. (author)
- Gorman, Mark (author)
- Kornek, Barbara (author)
- Krupp, Lauren (author)
- Krysko, Kristen M. (author)
- Nosadini, Margherita (author)
- Rostasy, Kevin (author)
- Schreiner, Teri (author)
- Tenembaum, Silvia (author)
- Waubant, Emmanuelle (author)
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- (creator_code:org_t)
- 2020-06-19
- 2021
- English.
- In: Multiple Sclerosis Journal. - : Sage Publications. - 1352-4585 .- 1477-0970. ; 27:12, s. 1814-1822
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Anti-CD20 therapies have established efficacy in the treatment of immune-mediated neurological and non-neurological diseases. Rituximab, one of the first B-cell-directed therapies, is relatively inexpensive compared to newer anti-CD20 molecules, is available in many countries, and has been used off-label in pediatric patients with neuroimmune conditions. The objective of this paper is to describe the experience with rituximab in pediatric multiple sclerosis and other inflammatory immune-mediated disorders of the central nervous system (CNS), and to define a protocol for its use in clinical practice, in particular addressing doses, interval of administration, duration of treatment, and tests to perform at baseline and during follow-up.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Pediatric multiple sclerosis
- rituximab
- CD19+cells
- CD20+cells
- anti-CD20 therapy
Publication and Content Type
- ref (subject category)
- art (subject category)
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- Ghezzi, Angelo
- Banwell, Brenda
- Bar-Or, Amit
- Chitnis, Tanuja
- Dale, Russell C.
- Gorman, Mark
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- Kornek, Barbara
- Krupp, Lauren
- Krysko, Kristen ...
- Nosadini, Marghe ...
- Rostasy, Kevin
- Salzer, Jonatan
- Schreiner, Teri
- Tenembaum, Silvi ...
- Waubant, Emmanue ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Neurosciences
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- Multiple Scleros ...
- By the university
- Umeå University
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