SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Servage Kelly A.)
 

Sökning: WFRF:(Servage Kelly A.) > A Bacterial Effecto...

A Bacterial Effector Mimics a Host HSP90 Client to Undermine Immunity

Lopez, Victor A. (författare)
University of Texas Southwestern Medical Center
Park, Brenden C. (författare)
University of Texas Southwestern Medical Center
Nowak, Dominika (författare)
Institute of Biochemistry and Biophysics of the Polish Academy of Sciences
visa fler...
Sreelatha, Anju (författare)
University of Texas Southwestern Medical Center
Zembek, Patrycja (författare)
Institute of Biochemistry and Biophysics of the Polish Academy of Sciences
Fernandez, Jessie (författare)
University of Texas Southwestern Medical Center
Servage, Kelly A. (författare)
University of Texas Southwestern Medical Center,Howard Hughes Medical Institute
Gradowski, Marcin (författare)
Warsaw University of Life Sciences
Hennig, Jacek (författare)
Institute of Biochemistry and Biophysics of the Polish Academy of Sciences
Tomchick, Diana R. (författare)
University of Texas Southwestern Medical Center
Pawłowski, Krzysztof (författare)
Lund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups,Warsaw University of Life Sciences
Krzymowska, Magdalena (författare)
Institute of Biochemistry and Biophysics of the Polish Academy of Sciences
Tagliabracci, Vincent S. (författare)
University of Texas Southwestern Medical Center
visa färre...
 (creator_code:org_t)
Elsevier BV, 2019
2019
Engelska.
Ingår i: Cell. - : Elsevier BV. - 0092-8674. ; 179:1, s. 21-218
Relaterad länk:
http://dx.doi.org/10...
visa fler...
http://www.cell.com/...
https://lup.lub.lu.s...
https://doi.org/10.1...
visa färre...
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • The molecular chaperone HSP90 facilitates the folding of several client proteins, including innate immune receptors and protein kinases. HSP90 is an essential component of plant and animal immunity, yet pathogenic strategies that directly target the chaperone have not been described. Here, we identify the HopBF1 family of bacterial effectors as eukaryotic-specific HSP90 protein kinases. HopBF1 adopts a minimal protein kinase fold that is recognized by HSP90 as a host client. As a result, HopBF1 phosphorylates HSP90 to completely inhibit the chaperone's ATPase activity. We demonstrate that phosphorylation of HSP90 prevents activation of immune receptors that trigger the hypersensitive response in plants. Consequently, HopBF1-dependent phosphorylation of HSP90 is sufficient to induce severe disease symptoms in plants infected with the bacterial pathogen, Pseudomonas syringae. Collectively, our results uncover a family of bacterial effector kinases with toxin-like properties and reveal a previously unrecognized betrayal mechanism by which bacterial pathogens modulate host immunity.

Ämnesord

NATURVETENSKAP  -- Biologi -- Cellbiologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Cell Biology (hsv//eng)
NATURVETENSKAP  -- Biologi -- Immunologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Immunology (hsv//eng)

Nyckelord

chaperone
effector
HopBF1
HSP90
immunity
kinase
phosphorylation
Pseudomonas syringae

Publikations- och innehållstyp

art (ämneskategori)
ref (ämneskategori)

Hitta via bibliotek

  • Cell (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy