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  • Simonson, Oscar E.Karolinska Inst, Dept Mol Med & Surg, Karolinska Univ Hosp, Stockholm, Sweden.;Karolinska Inst, Dept Cardiothorac Surg & Anesthesia, Karolinska Univ Hosp, Stockholm, Sweden.;Karolinska Inst, Dept Lab Med, Karolinska Univ Hosp, Stockholm, Sweden. (author)

In Vivo Effects of Mesenchymal Stromal Cells in Two Patients With Severe Acute Respiratory Distress Syndrome

  • Article/chapterEnglish2015

Publisher, publication year, extent ...

  • 2015-08-18
  • Oxford University Press (OUP),2015
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-265697
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-265697URI
  • https://doi.org/10.5966/sctm.2015-0021DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:132122757URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • De 2 första författarna delar förstaförfattarskapet.De 3 sista författarna delar sistaförfattarskapet.
  • Mesenchymal stromal cells (MSCs) have been investigated as a treatment for various inflammatory diseases because of their immunomodulatory and reparative properties. However, many basic questions concerning their mechanisms of action after systemic infusion remain unanswered. We performed a detailed analysis of the immunomodulatory properties and proteomic profile of MSCs systemically administered to two patients with severe refractory acute respiratory distress syndrome (ARDS) on a compassionate use basis and attempted to correlate these with in vivo anti-inflammatory actions. Both patients received 2 x 10(6) cells per kilogram, and each subsequently improved with resolution of respiratory, hemodynamic, and multiorgan failure. In parallel, a decrease was seen in multiple pulmonary and systemic markers of inflammation, including epithelial apoptosis, alveolar-capillary fluid leakage, and proinflammatory cytokines, microRNAs, and chemokines. In vitro studies of the MSCs demonstrated a broad anti-inflammatory capacity, including suppression of T-cell responses and induction of regulatory phenotypes in T cells, monocytes, and neutrophils. Some of these in vitro potency assessments correlated with, and were relevant to, the observed in vivo actions. These experiences highlight both the mechanistic information that can be gained from clinical experience and the value of correlating in vitro potency assessments with clinical effects. The findings also suggest, but do not prove, a beneficial effect of lung protective strategies using adoptively transferred MSCs in ARDS. Appropriate randomized clinical trials are required to further assess any potential clinical efficacy and investigate the effects on in vivo inflammation. STEM CELLS TRANSLATIONAL MEDICINE 2015;4:1199-1213

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Mougiakakos, DimitriosUniv Erlangen Nurnberg, Dept Internal Med Hematol & Oncol, D-91054 Erlangen, Germany. (author)
  • Heldring, NinaKarolinska Institutet (author)
  • Bassi, GiulioUniv Verona, Dept Med, Sect Hematol, Stem Cell Res Lab, I-37100 Verona, Italy. (author)
  • Johansson, Henrik J.Karolinska Institutet (author)
  • Dalen, MagnusKarolinska Institutet (author)
  • Jitschin, ReginaKarolinska Inst, Dept Lab Med, Karolinska Univ Hosp, Stockholm, Sweden. (author)
  • Rodin, SergeyKarolinska Institutet (author)
  • Corbascio, MatthiasKarolinska Institutet (author)
  • El Andaloussi, SamirKarolinska Institutet (author)
  • Wiklander, Oscar P. B.Karolinska Institutet (author)
  • Nordin, Joel Z.Karolinska Institutet (author)
  • Skog, JohanExosome Diagnost Inc, New York, NY USA. (author)
  • Romain, CharlotteExosome Diagnost Inc, New York, NY USA. (author)
  • Koestler, TinaExosome Diagnost Inc, New York, NY USA. (author)
  • Johansson Hellgren, LailaUppsala universitet,Thoraxkirurgi(Swepub:uu)lahel172 (author)
  • Schiller, PetterUppsala universitet,Thoraxkirurgi(Swepub:uu)pesch021 (author)
  • Joachimsson, Per-OlofUppsala universitet,Anestesiologi och intensivvård(Swepub:uu)pejoa103 (author)
  • Hägglund, HansKarolinska Institutet,Uppsala universitet,Hematologi,Univ Uppsala Hosp, Dept Hematol, Uppsala, Sweden.(Swepub:uu)hanha689 (author)
  • Mattsson, MattiasUppsala universitet,Hematologi,Univ Uppsala Hosp, Dept Hematol, Uppsala, Sweden.(Swepub:uu)matma431 (author)
  • Lentio, Janne (author)
  • Faridani, Omid R.Ludwig Inst Canc Res, S-10401 Stockholm, Sweden. (author)
  • Sandberg, RickardKarolinska Institutet (author)
  • Korsgren, OlleUppsala universitet,Klinisk immunologi(Swepub:uu)ollekors (author)
  • Krampera, MauroUniv Verona, Dept Med, Sect Hematol, Stem Cell Res Lab, I-37100 Verona, Italy. (author)
  • Weiss, Daniel J.Univ Vermont, Dept Med, Hlth Sci Res Facil, Burlington, VT USA. (author)
  • Grinnemo, Karl-HenrikKarolinska Inst, Dept Mol Med & Surg, Karolinska Univ Hosp, Stockholm, Sweden.;Karolinska Inst, Dept Cardiothorac Surg & Anesthesia, Karolinska Univ Hosp, Stockholm, Sweden.;Vaccine & Gene Therapy Inst Florida, Ctr Dis Aging, Port St Lucie, FL USA. (author)
  • Le Blanc, KatarinaKarolinska Institutet (author)
  • Karolinska Inst, Dept Mol Med & Surg, Karolinska Univ Hosp, Stockholm, Sweden.;Karolinska Inst, Dept Cardiothorac Surg & Anesthesia, Karolinska Univ Hosp, Stockholm, Sweden.;Karolinska Inst, Dept Lab Med, Karolinska Univ Hosp, Stockholm, Sweden.Univ Erlangen Nurnberg, Dept Internal Med Hematol & Oncol, D-91054 Erlangen, Germany. (creator_code:org_t)

Related titles

  • In:Stem Cells Translational Medicine: Oxford University Press (OUP)4:10, s. 1199-12132157-65642157-6580

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