Automated mitotic spindle hotspot counts are highly associated with clinical outcomes in systemically untreated early-stage triple-negative breast cancer

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Fältnamn	Indikatorer	Metadata
000		04525naa a2200457 4500
001		oai:DiVA.org:liu-202499
003		SwePub
008		240416s2024 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-2024992 URI
024	7	a https://doi.org/10.1038/s41523-024-00629-32 DOI
040		a (SwePub)liu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Leon-Ferre, Roberto A.u Mayo Clin, MN 55905 USA4 aut
245	1 0	a Automated mitotic spindle hotspot counts are highly associated with clinical outcomes in systemically untreated early-stage triple-negative breast cancer
264	1	b NATURE PORTFOLIO,c 2024
338		a print2 rdacarrier
500		a Funding Agencies\|Supported in part by Mayo Clinic Breast Cancer SPORE grant P50 CA116201 (MPG and RLF), the George M. Eisenberg Foundation for Charities (MPG and JCB), NIH grant R35 CA253187 (FJC), the Breast Cancer Research Foundation (FJC), and the Mayo Clinic K2R Pipeli [P50 CA116201]; Mayo Clinic Breast Cancer SPORE; George M. Eisenberg Foundation for Charities [R35 CA253187]; NIH [P2-11-34]; Breast Cancer Research Foundation
520		a Operable triple-negative breast cancer (TNBC) has a higher risk of recurrence and death compared to other subtypes. Tumor size and nodal status are the primary clinical factors used to guide systemic treatment, while biomarkers of proliferation have not demonstrated value. Recent studies suggest that subsets of TNBC have a favorable prognosis, even without systemic therapy. We evaluated the association of fully automated mitotic spindle hotspot (AMSH) counts with recurrence-free (RFS) and overall survival (OS) in two separate cohorts of patients with early-stage TNBC who did not receive systemic therapy. AMSH counts were obtained from areas with the highest mitotic density in digitized whole slide images processed with a convolutional neural network trained to detect mitoses. In 140 patients from the Mayo Clinic TNBC cohort, AMSH counts were significantly associated with RFS and OS in a multivariable model controlling for nodal status, tumor size, and tumor-infiltrating lymphocytes (TILs) (p < 0.0001). For every 10-point increase in AMSH counts, there was a 16% increase in the risk of an RFS event (HR 1.16, 95% CI 1.08-1.25), and a 7% increase in the risk of death (HR 1.07, 95% CI 1.00-1.14). We corroborated these findings in a separate cohort of systemically untreated TNBC patients from Radboud UMC in the Netherlands. Our findings suggest that AMSH counts offer valuable prognostic information in patients with early-stage TNBC who did not receive systemic therapy, independent of tumor size, nodal status, and TILs. If further validated, AMSH counts could help inform future systemic therapy de-escalation strategies.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
700	1	a Carter, Jodi M.u Univ Alberta, Canada4 aut
700	1	a Zahrieh, Davidu Mayo Clin, MN 55905 USA4 aut
700	1	a Sinnwell, Jason P.u Mayo Clin, MN 55905 USA4 aut
700	1	a Salgado, Robertou GZA ZNA Hosp, Belgium; Peter Mac Callum Canc Ctr, Australia4 aut
700	1	a Suman, Vera J.u Mayo Clin, MN 55905 USA4 aut
700	1	a Hillman, David W.u Mayo Clin, MN 55905 USA4 aut
700	1	a Boughey, Judy C.u Mayo Clin, MN 55905 USA4 aut
700	1	a Kalari, Krishna R.u Mayo Clin, MN 55905 USA4 aut
700	1	a Couch, Fergus J.u Mayo Clin, MN 55905 USA4 aut
700	1	a Ingle, James N.u Mayo Clin, MN 55905 USA4 aut
700	1	a Balkenhol, Maschenkau Radboud Univ Nijmegen, Netherlands4 aut
700	1	a Ciompi, Francescou Radboud Univ Nijmegen, Netherlands4 aut
700	1	a van der Laak, Jeroenu Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Region Östergötland, Klinisk patologi,Radboud Univ Nijmegen, Netherlands4 aut0 (Swepub:liu)jerva26
700	1	a Goetz, Matthew P.u Mayo Clin, MN 55905 USA4 aut
710	2	a Mayo Clin, MN 55905 USAb Univ Alberta, Canada4 org
773	0	t npj Breast Cancerd : NATURE PORTFOLIOg 10:1q 10:1x 2374-4677
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-202499
856	4 8	u https://doi.org/10.1038/s41523-024-00629-3

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By the author/editor: Leon-Ferre, Robe ...; Carter, Jodi M.; Zahrieh, David; Sinnwell, Jason ...; Salgado, Roberto; Suman, Vera J.; show more...; Hillman, David W ...; Boughey, Judy C.; Kalari, Krishna ...; Couch, Fergus J.; Ingle, James N.; Balkenhol, Masch ...; Ciompi, Francesc ...; van der Laak, Je ...; Goetz, Matthew P ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

Articles in the publication: npj Breast Cance ...

By the university: Linköping University

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