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Sökning: WFRF:(Sjöblom Liisa) > (2016) > Microseminoprotein-...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004341naa a2200481 4500
001oai:lup.lub.lu.se:4d63a6f7-1819-4fea-a4c0-0ce731ffc3eb
003SwePub
008160404s2016 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/88563452 URI
0247 a https://doi.org/10.1371/journal.pone.01502412 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Sjöblom, Liisa4 aut
2451 0a Microseminoprotein-Beta Expression in Different Stages of Prostate Cancer.
264 c 2016-03-03
264 1b Public Library of Science (PLoS),c 2016
520 a Microseminoprotein-beta (MSMB, MSMB) is an abundant secretory protein contributed by the prostate, and is implicated as a prostate cancer (PC) biomarker based on observations of its lower expression in cancerous cells compared with benign prostate epithelium. However, as the current literature on MSMB is inconsistent, we assessed the expression of MSMB at the protein and mRNA levels in a comprehensive set of different clinical stages of PC. Immunohistochemistry using monoclonal and polyclonal antibodies against MSMB was used to study protein expression in tissue specimens representing prostatectomies (n = 261) and in diagnostic needle biopsies from patients treated with androgen deprivation therapy (ADT) (n = 100), and in locally recurrent castration-resistant PC (CRPC) (n = 105) and CRPC metastases (n = 113). The transcript levels of MSMB, nuclear receptor co-activator 4 (NCOA4) and MSMB-NCOA4 fusion were examined by qRT-PCR in prostatectomy samples and by RNA-sequencing in benign prostatic hyperplasia, PC, and CRPC samples. We also measured serum MSMB levels and genotyped the single nucleotide polymorphism rs10993994 using DNA from the blood of 369 PC patients and 903 controls. MSMB expression in PC (29% of prostatectomies and 21% of needle biopsies) was more frequent than in CRPC (9% of locally recurrent CRPCs and 9% of CRPC metastases) (p<0.0001). Detection of MSMB protein was inversely correlated with the Gleason score in prostatectomy specimens (p = 0.024). The read-through MSMB-NCOA4 transcript was detected at very low levels in PC. MSMB levels in serum were similar in cases of PC and controls but were significantly associated with PC risk when adjusted for age at diagnosis and levels of free or total PSA (p<0.001). Serum levels of MSMB in both PC patients and controls were significantly associated with the rs10993994 genotype (p<0.0001). In conclusion, decreased expression of MSMB parallels the clinical progression of PC and adjusted serum MSMB levels are associated with PC risk.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng
7001 a Saramäki, Outi4 aut
7001 a Annala, Matti4 aut
7001 a Leinonen, Katri4 aut
7001 a Nättinen, Janika4 aut
7001 a Tolonen, Teemu4 aut
7001 a Wahlfors, Tiina4 aut
7001 a Nykter, Matti4 aut
7001 a Bova, G Steven4 aut
7001 a Schleutker, Johanna4 aut
7001 a Tammela, Teuvo L J4 aut
7001 a Lilja, Hansu Lund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)klke-hli
7001 a Visakorpi, Tapio4 aut
7102 a Klinisk kemi, Malmöb Forskargrupper vid Lunds universitet4 org
7730 t PLoS ONEd : Public Library of Science (PLoS)g 11:3q 11:3x 1932-6203
8564 u http://www.ncbi.nlm.nih.gov/pubmed/26939004?dopt=Abstracty FULLTEXT
8564 u http://dx.doi.org/10.1371/journal.pone.0150241x freey FULLTEXT
8564 u https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0150241&type=printable
8564 8u https://lup.lub.lu.se/record/8856345
8564 8u https://doi.org/10.1371/journal.pone.0150241

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