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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03341naa a2200481 4500 | |
| 001 | oai:gup.ub.gu.se/318275 | |
| 003 | SwePub | |
| 008 | 240528s2022 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://gup.ub.gu.se/publication/3182752 URI |
| 024 | 7 | a https://doi.org/10.1038/s42255-022-00607-82 DOI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Gloyn, A. L.4 aut |
| 245 | 1 0 | a Every islet matters: improving the impact of human islet research |
| 264 | c 2022-08-11 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2022 |
| 520 | a The authors of this Perspective summarize the state of human islet research and compare available islet procurement methods, proposing strategies to increase collaboration and standardization to accelerate discoveries on diabetes. Detailed characterization of human pancreatic islets is key to elucidating the pathophysiology of all forms of diabetes, especially type 2 diabetes. However, access to human pancreatic islets is limited. Pancreatic tissue for islet retrieval can be obtained from brain-dead organ donors or from individuals undergoing pancreatectomy, often referred to as 'living donors'. Different protocols for human islet procurement can substantially impact islet function. This variability, coupled with heterogeneity between individuals and islets, results in analytical challenges to separate genuine disease pathology or differences between human donors from experimental noise. There are currently no international guidelines for human donor phenotyping, islet procurement and functional characterization. This lack of standardization means that substantial investments from multiple international efforts towards improved understanding of diabetes pathology cannot be fully leveraged. In this Perspective, we overview the status of the field of human islet research, highlight the challenges and propose actions that could accelerate research progress and increase understanding of type 2 diabetes to slow its pandemic spreading. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
| 653 | a pancreatectomized patients | |
| 653 | a glucose-metabolism | |
| 653 | a donors | |
| 653 | a organ | |
| 653 | a genes | |
| 653 | a pathophysiology | |
| 653 | a transplantation | |
| 653 | a individuals | |
| 653 | a secretion | |
| 653 | a pancreas | |
| 653 | a Endocrinology & Metabolism | |
| 700 | 1 | a Ibberson, M.4 aut |
| 700 | 1 | a Marchetti, P.4 aut |
| 700 | 1 | a Powers, A. C.4 aut |
| 700 | 1 | a Rorsman, Patrik,d 1959u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology4 aut0 (Swepub:gu)xrorpa |
| 700 | 1 | a Sander, M.4 aut |
| 700 | 1 | a Solimena, M.4 aut |
| 710 | 2 | a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi4 org |
| 773 | 0 | t Nature Metabolismd : Springer Science and Business Media LLCg 4, s. 970-977q 4<970-977x 2522-5812 |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/318275 |
| 856 | 4 8 | u https://doi.org/10.1038/s42255-022-00607-8 |
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