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Burkitt Lymphoma In...
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Olszewski, Adam J.Brown University
(författare)
Burkitt Lymphoma International Prognostic Index
- Artikel/kapitelEngelska2021
Förlag, utgivningsår, omfång ...
Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:253268fe-3739-4ded-92c9-a425c507d2ae
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https://lup.lub.lu.se/record/253268fe-3739-4ded-92c9-a425c507d2aeURI
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https://doi.org/10.1200/JCO.20.03288DOI
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Språk:engelska
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Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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PURPOSE: Burkitt lymphoma (BL) has unique biology and clinical course but lacks a standardized prognostic model. We developed and validated a novel prognostic index specific for BL to aid risk stratification, interpretation of clinical trials, and targeted development of novel treatment approaches. METHODS: We derived the BL International Prognostic Index (BL-IPI) from a real-world data set of adult patients with BL treated with immunochemotherapy in the United States between 2009 and 2018, identifying candidate variables that showed the strongest prognostic association with progression-free survival (PFS). The index was validated in an external data set of patients treated in Europe, Canada, and Australia between 2004 and 2019. RESULTS: In the derivation cohort of 633 patients with BL, age ≥ 40 years, performance status ≥ 2, serum lactate dehydrogenase > 3× upper limit of normal, and CNS involvement were selected as equally weighted factors with an independent prognostic value. The resulting BL-IPI identified groups with low (zero risk factors, 18% of patients), intermediate (one factor, 36% of patients), and high risk (≥ 2 factors, 46% of patients) with 3-year PFS estimates of 92%, 72%, and 53%, respectively, and 3-year overall survival estimates of 96%, 76%, and 59%, respectively. The index discriminated outcomes regardless of HIV status, stage, or first-line chemotherapy regimen. Patient characteristics, relative size of the BL-IPI groupings, and outcome discrimination were consistent in the validation cohort of 457 patients, with 3-year PFS estimates of 96%, 82%, and 63% for low-, intermediate-, and high-risk BL-IPI, respectively. CONCLUSION: The BL-IPI provides robust discrimination of survival in adult BL, suitable for use as prognostication and stratification in trials. The high-risk group has suboptimal outcomes with standard therapy and should be considered for innovative treatment approaches.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Jakobsen, Lasse H.Aalborg University Hospital
(författare)
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Collins, Graham P.Oxford University Hospitals NHS Foundation Trust
(författare)
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Cwynarski, KateUniversity College London Hospital
(författare)
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Bachanova, VeronikaUniversity of Minnesota
(författare)
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Blum, Kristie A.Emory University
(författare)
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Boughan, Kirsten M.University Hospitals Case Medical Center
(författare)
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Bower, MarkChelsea and Westminster Hospital
(författare)
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Dalla Pria, AlessiaChelsea and Westminster Hospital
(författare)
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Danilov, AlexeyCity of Hope National Medical Center
(författare)
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David, Kevin A.Rutgers Cancer Institute of New Jersey
(författare)
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Diefenbach, CatherineNYU Langone
(författare)
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Ellin, FredrikLund University,Lunds universitet,Lymfom - Klinisk forskning,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Lymphoma - Clinical Research,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments(Swepub:lu)med-fke
(författare)
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Epperla, NarendranathOhio State University
(författare)
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Farooq, UmarUniversity of Iowa
(författare)
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Feldman, Tatyana A.Hackensack University Medical Center,Hackensack Meridian Health School of Medicine
(författare)
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Gerrie, Alina S.University of British Columbia
(författare)
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Jagadeesh, DeepaCleveland Clinic Taussig Cancer Center
(författare)
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Kamdar, ManaliUniversity of Colorado
(författare)
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Karmali, ReemNorthwestern University
(författare)
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Kassam, ShireenKing's College Hospital
(författare)
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Kenkre, Vaishalee P.University of Wisconsin Carbone Cancer Center
(författare)
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Khan, NadiaFox Chase Cancer Center
(författare)
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Kim, Seo HyunRush University Medical Center Chicago
(författare)
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Klein, Andreas K.Tufts Medical Center
(författare)
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Lossos, Izidore S.University of Miami
(författare)
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Lunning, Matthew A.University of Nebraska Medical Center
(författare)
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Martin, PeterNew York Presbyterian Hospital/Columbia University Medical Center
(författare)
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Martinez-Calle, NicolasNottingham University Hospitals NHS Trust
(författare)
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Montoto, SilviaBarts Health NHS Trust
(författare)
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Naik, SeemaPenn State Hershey Cancer Institute
(författare)
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Palmisiano, NeilThomas Jefferson University
(författare)
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Peace, DavidUniversity of Illinois at Chicago
(författare)
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Phillips, Elizabeth H.University of Manchester
(författare)
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Phillips, Tycel J.University of Michigan Rogel Cancer Center
(författare)
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Portell, Craig A.University of Virginia
(författare)
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Reddy, NishithaVanderbilt University Medical Center
(författare)
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Santarsieri, AnnaCambridge University Hospitals NHS Foundation Trust
(författare)
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Sarraf Yazdy, MaryamMedStar Georgetown University Hospital
(författare)
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Smeland, Knut B.Oslo university hospital
(författare)
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Smith, Scott E.Loyola University Medical Center
(författare)
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Smith, Stephen D.Fred Hutchinson Cancer Research Center
(författare)
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Sundaram, SuchitraRoswell Park Cancer Institute
(författare)
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Zayac, Adam S.Brown University
(författare)
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Zhang, Xiao YinOxford University Hospitals NHS Foundation Trust
(författare)
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Zhu, CatherineUniversity College London Hospital
(författare)
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Cheah, Chan Y.Sir Charles Gairdner Hospital
(författare)
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El-Galaly, Tarec C.Aalborg University Hospital
(författare)
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Evens, Andrew M.Rutgers Cancer Institute of New Jersey
(författare)
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Brown UniversityAalborg University Hospital
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of clinical oncology : official journal of the American Society of Clinical Oncology39:10, s. 1129-11380732-183X
Internetlänk
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Till lärosätets databas
- Av författaren/redakt...
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Olszewski, Adam ...
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Jakobsen, Lasse ...
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Collins, Graham ...
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Cwynarski, Kate
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Bachanova, Veron ...
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Blum, Kristie A.
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visa fler...
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Boughan, Kirsten ...
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Bower, Mark
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Dalla Pria, Ales ...
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Danilov, Alexey
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David, Kevin A.
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Diefenbach, Cath ...
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Ellin, Fredrik
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Epperla, Narendr ...
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Farooq, Umar
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Feldman, Tatyana ...
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Gerrie, Alina S.
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Jagadeesh, Deepa
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Kamdar, Manali
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Karmali, Reem
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Kassam, Shireen
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Kenkre, Vaishale ...
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Khan, Nadia
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Kim, Seo Hyun
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Klein, Andreas K ...
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Lossos, Izidore ...
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Lunning, Matthew ...
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Martin, Peter
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Martinez-Calle, ...
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Montoto, Silvia
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Naik, Seema
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Palmisiano, Neil
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Peace, David
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Phillips, Elizab ...
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Phillips, Tycel ...
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Portell, Craig A ...
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Reddy, Nishitha
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Santarsieri, Ann ...
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Sarraf Yazdy, Ma ...
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Smeland, Knut B.
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Smith, Scott E.
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Smith, Stephen D ...
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Sundaram, Suchit ...
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Zayac, Adam S.
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Zhang, Xiao Yin
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Zhu, Catherine
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Cheah, Chan Y.
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El-Galaly, Tarec ...
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Evens, Andrew M.
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