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Sökning: WFRF:(Syro L V) > (2022) > Clinical Biology of...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04106naa a2200637 4500 | |
| 001 | oai:gup.ub.gu.se/316414 | |
| 003 | SwePub | |
| 008 | 240528s2022 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://gup.ub.gu.se/publication/3164142 URI |
| 024 | 7 | a https://doi.org/10.1210/endrev/bnac0102 DOI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Melmed, S.4 aut |
| 245 | 1 0 | a Clinical Biology of the Pituitary Adenoma |
| 264 | c 2022-04-08 | |
| 264 | 1 | b The Endocrine Society,c 2022 |
| 520 | a All endocrine glands are susceptible to neoplastic growth, yet the health consequences of these neoplasms differ between endocrine tissues. Pituitary neoplasms are highly prevalent and overwhelmingly benign, exhibiting a spectrum of diverse behaviors and impact on health. To understand the clinical biology of these common yet often innocuous neoplasms, we review pituitary physiology and adenoma epidemiology, pathophysiology, behavior, and clinical consequences. The anterior pituitary develops in response to a range of complex brain signals integrating with intrinsic ectodermal cell transcriptional events that together determine gland growth, cell type differentiation, and hormonal production, in turn maintaining optimal endocrine health. Pituitary adenomas occur in 10% of the population; however, the overwhelming majority remain harmless during life. Triggered by somatic or germline mutations, disease-causing adenomas manifest pathogenic mechanisms that disrupt intrapituitary signaling to promote benign cell proliferation associated with chromosomal instability. Cellular senescence acts as a mechanistic buffer protecting against malignant transformation, an extremely rare event. It is estimated that fewer than one-thousandth of all pituitary adenomas cause clinically significant disease. Adenomas variably and adversely affect morbidity and mortality depending on cell type, hormone secretory activity, and growth behavior. For most clinically apparent adenomas, multimodal therapy controlling hormone secretion and adenoma growth lead to improved quality of life and normalized mortality. The clinical biology of pituitary adenomas, and particularly their benign nature, stands in marked contrast to other tumors of the endocrine system, such as thyroid and neuroendocrine tumors. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
| 653 | a pituitary adenoma | |
| 653 | a acromegaly | |
| 653 | a prolactinoma | |
| 653 | a Cushing's disease | |
| 653 | a aggressive pituitary tumor | |
| 653 | a hypothalamus | |
| 653 | a radiological vertebral fractures | |
| 653 | a mccune-albright syndrome | |
| 653 | a tumor-transforming gene | |
| 653 | a growth-hormone hypersecretion | |
| 653 | a cavernous sinus | |
| 653 | a space | |
| 653 | a cushings-syndrome | |
| 653 | a neuroendocrine tumors | |
| 653 | a transcription factors | |
| 653 | a cardiovascular risk | |
| 653 | a natural-history | |
| 653 | a Endocrinology & Metabolism | |
| 700 | 1 | a Kaiser, U. B.4 aut |
| 700 | 1 | a Lopes, M. B.4 aut |
| 700 | 1 | a Bertherat, J.4 aut |
| 700 | 1 | a Syro, L. V.4 aut |
| 700 | 1 | a Raverot, G.4 aut |
| 700 | 1 | a Reincke, M.4 aut |
| 700 | 1 | a Johannsson, Gudmundur,d 1960u Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine4 aut0 (Swepub:gu)xjgudn |
| 700 | 1 | a Beckers, A.4 aut |
| 700 | 1 | a Fleseriu, M.4 aut |
| 700 | 1 | a Giustina, A.4 aut |
| 700 | 1 | a Wass, J. A. H.4 aut |
| 700 | 1 | a Ho, K. K. Y.4 aut |
| 710 | 2 | a Göteborgs universitetb Institutionen för medicin4 org |
| 773 | 0 | t Endocrine Reviewsd : The Endocrine Societyg 43:6, s. 1003-1037q 43:6<1003-1037x 0163-769Xx 1945-7189 |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/316414 |
| 856 | 4 8 | u https://doi.org/10.1210/endrev/bnac010 |
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