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Sökning: WFRF:(Szeman Nágy Gábor) > Individual variabil...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003763naa a2200481 4500
001oai:DiVA.org:su-147032
003SwePub
008170927s2017 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1470322 URI
0247 a https://doi.org/10.1016/j.toxicon.2017.06.0042 DOI
040 a (SwePub)su
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Malina, Tamás4 aut
2451 0a Individual variability of venom from the European adder (Vipera berus berus) from one locality in Eastern Hungary
264 1b Elsevier BV,c 2017
338 a print2 rdacarrier
520 a We have revealed intra-population variability among venom samples from several individual European adders (Vipera berus berus) within a defined population in Eastern Hungary. Individual differences in venom pattern were noticed, both gender-specific and age-related, by one-dimensional electrophoresis. Gelatin zymography demonstrated that these individual venoms have different degradation profiles indicating varying protease activity in the specimens from adders of different ages and genders. Some specimens shared a conserved region of substrate degradation, while others had lower or extremely low protease activity. Phospholipase A(2) activity of venoms was similar but not identical. Interspecimen diversity of the venom phospholipase A(2)-spectra (based on the components' molecular masses) was detected by MALDI-TOF MS. The lethal toxicity of venoms (LD50) also showed differences among individual snakes. Extracted venom samples had varying neuromuscular paralysing effect on chick biventer cervicis nerve-muscle preparations. The paralysing effect of venom was lost when calcium in the physiological salt solution was replaced by strontium; indicating that the block of twitch responses to nerve stimulation is associated with the activity of a phospholipase-dependent neurotoxin. In contrast to the studied V.b. berus venoms from different geographical regions so far, this is the first V.b berus population discovered to have predominantly neurotoxic neuromuscular activity. The relevance of varying venom yields is also discussed. This study demonstrates that individual venom variation among V.b. berus living in particular area of Eastern Hungary might contribute to a wider range of clinical manifestations of V.b. hems envenoming than elsewhere in Europe.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmaceutiska vetenskaper0 (SwePub)301012 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmaceutical Sciences0 (SwePub)301012 hsv//eng
653 a Intra-species venom variation
653 a Neurotoxic
653 a Phospholipase A(2)
653 a Protease
653 a Vipera berus berus
7001 a Krecsák, László4 aut
7001 a Westerström, Alexanderu Stockholms universitet,Fysikum4 aut
7001 a Szeman-Nágy, Gábor4 aut
7001 a Gyémánt, Gyöengyi4 aut
7001 a M-Hamvas, Márta4 aut
7001 a Rowan, Edward G.4 aut
7001 a Harvey, Alan L.4 aut
7001 a Warrell, David A.4 aut
7001 a Pál, Balázs4 aut
7001 a Rusznák, Zoltán4 aut
7001 a Vasas, Gábor4 aut
7102 a Stockholms universitetb Fysikum4 org
7730 t Toxicond : Elsevier BVg 135, s. 59-70q 135<59-70x 0041-0101x 1879-3150
8564 u https://strathprints.strath.ac.uk/61460/1/Malina_etal_Toxicon_2017_Individual_variability_of_venom_from_the_European_adder.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-147032
8564 8u https://doi.org/10.1016/j.toxicon.2017.06.004

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