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Sökning: WFRF:(Tartaro Gianpaolo) > (2017) > Patients with high ...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003693naa a2200517 4500
001oai:DiVA.org:umu-141977
003SwePub
008171206s2017 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1419772 URI
0247 a https://doi.org/10.1111/jop.125792 DOI
040 a (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Strindlund, Klasu Umeå universitet,Patologi4 aut0 (Swepub:umu)klst0005
2451 0a Patients with high c-MYC-expressing squamous cell carcinomas of the tongue show better survival than those with low- and medium-expressing tumours
264 c 2017-05-09
264 1b John Wiley & Sons,c 2017
338 a print2 rdacarrier
520 a Backgroundc-MYC is a potent oncoprotein with roles in a wide range of cellular processes such as differentiation, apoptosis and growth control. Deregulation of the MYC gene is commonly seen in human tumours resulting in overexpression of the protein. Here we studied expression of c-MYC in correlation to clinical outcome in patients with primary squamous cell carcinoma of the mobile tongue. MethodsImmunohistochemistry was used to identify c-MYC in a group of 104 tongue squamous cell carcinomas with an antibody directed against the N-terminal part of the protein. Staining was evaluated by multiplying the percentage of c-MYC-expressing cells with staining intensity, giving a quick score for each tumour. ResultsAll 104 tumours expressed c-MYC at varying levels. Quantitation according to per cent of positive cells and staining intensity revealed that most (15/21; 71%) high-expressing tumours were seen in males. Within the group of high c-MYC-expressing tumours, the majority were alive 2 and 5 years after treatment. ConclusionsThe present findings show that expression of c-MYC has prognostic value in squamous cell carcinoma of the tongue, and could be useful in choice of therapy.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a c-MYC
653 a radiotherapy
653 a squamous cell carcinoma
653 a tongue
7001 a Troiano, Giuseppe4 aut
7001 a Sgaramella, Nicola4 aut
7001 a Coates, Philip J.4 aut
7001 a Gu, Xiaolianu Umeå universitet,Patologi4 aut0 (Swepub:umu)xinguu04
7001 a Boldrup, Lindau Umeå universitet,Patologi4 aut0 (Swepub:umu)liabop98
7001 a Califano, Luigi4 aut
7001 a Fåhraeus, Robinu Umeå universitet,Patologi,RECAMO, Masaryk Memorial Cancer Institute, Brno, Czech Republic; Institut de Génétique Moléculaire, Hôpital St. Louis, Université Paris 7, Paris, France4 aut0 (Swepub:umu)rofa0013
7001 a Muzio, Lorenzo Lo4 aut
7001 a Ardito, Fatima4 aut
7001 a Colella, Giuseppe4 aut
7001 a Tartaro, Gianpaolo4 aut
7001 a Franco, Renato4 aut
7001 a Norberg-Spaak, Lenau Umeå universitet,Öron- näs- och halssjukdomar4 aut0 (Swepub:umu)leno0027
7001 a Saadat, Mohammadu Umeå universitet,Öron- näs- och halssjukdomar4 aut0 (Swepub:umu)mosa0037
7001 a Nylander, Karinu Umeå universitet,Patologi4 aut0 (Swepub:umu)kaanyr77
7102 a Umeå universitetb Patologi4 org
7730 t Journal of Oral Pathology & Medicined : John Wiley & Sonsg 46:10, s. 967-971q 46:10<967-971x 0904-2512x 1600-0714
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-141977
8564 8u https://doi.org/10.1111/jop.12579

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