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Ototoxicity associa...
Ototoxicity associated with extended dalbavancin treatment for a shoulder prosthetic joint infection
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- Lange, Anna, 1975- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Infectious Diseases
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- Thunberg, Ulrica, 1967- (author)
- Örebro universitet,Institutionen för hälsovetenskaper,Institutionen för medicinska vetenskaper,Department of Otorhinolaryngology
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- Söderquist, Bo, 1955- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper
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(creator_code:org_t)
- BioMed Central (BMC), 2023
- 2023
- English.
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In: BMC Infectious Diseases. - : BioMed Central (BMC). - 1471-2334. ; 23:1
- Related links:
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https://doi.org/10.1...
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Abstract
Subject headings
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- BACKGROUND: Dalbavancin is a lipoglycopeptide antibiotic approved for treatment of skin and soft tissue infections, administered as a single or two-dose treatment. The extended half-life, good penetration into bone and synovial fluid, and bactericidal activity against gram-positive bacteria, including those in biofilm, make dalbavancin an appealing choice for treatment of bone and joint infections in outpatient settings. However, we present a rare case of ototoxicity associated with off-label extended dalbavancin treatment of a prosthetic joint infection.CASE PRESENTATION: A 55-year-old man with a prosthetic joint infection of the shoulder underwent off-label extended dalbavancin treatment, receiving a cumulative dose of 2500 mg. The patient experienced a gradual onset of hearing loss following the first dose, leading to a diagnosis of bilateral sensorineural hearing loss that persisted 1 year after dalbavancin was discontinued.CONCLUSIONS: This case report highlights the importance of exercising caution when administering dalbavancin beyond approved dosing guidelines, and emphasizes the need for vigilance regarding the potential for ototoxicity.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Keyword
- Dalbavancin
- Ototoxicity
- Prosthetic joint infection
Publication and Content Type
- ref (subject category)
- art (subject category)
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