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Sökning: WFRF:(Thyssen Stine) > (2015) > Genetic ablation of...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004044naa a2200409 4500
001oai:lup.lub.lu.se:a5927605-f50f-478b-8ac2-b9701fd087e7
003SwePub
008160404s2015 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/85050272 URI
0247 a https://doi.org/10.1177/0271678X156103392 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Madsen, Pernille M4 aut
2451 0a Genetic ablation of soluble tumor necrosis factor with preservation of membrane tumor necrosis factor is associated with neuroprotection after focal cerebral ischemia.
264 1c 2015
520 a Microglia respond to focal cerebral ischemia by increasing their production of the neuromodulatory cytokine tumor necrosis factor, which exists both as membrane-anchored tumor necrosis factor and as cleaved soluble tumor necrosis factor forms. We previously demonstrated that tumor necrosis factor knockout mice display increased lesion volume after focal cerebral ischemia, suggesting that tumor necrosis factor is neuroprotective in experimental stroke. Here, we extend our studies to show that mice with intact membrane-anchored tumor necrosis factor, but no soluble tumor necrosis factor, display reduced infarct volumes at one and five days after stroke. This was associated with improved functional outcome after experimental stroke. No changes were found in the mRNA levels of tumor necrosis factor and tumor necrosis factor-related genes (TNFR1, TNFR2, TACE), pro-inflammatory cytokines (IL-1β, IL-6) or chemokines (CXCL1, CXCL10, CCL2); however, protein expression of TNF, IL-1β, IL-6 and CXCL1 was reduced in membrane-anchored tumor necrosis factor(Δ/Δ) compared to membrane-anchored tumor necrosis factor(wt/wt) mice one day after experimental stroke. This was paralleled by reduced MHCII expression and a reduction in macrophage infiltration in the ipsilateral cortex of membrane-anchored tumor necrosis factor(Δ/Δ) mice. Collectively, these findings indicate that membrane-anchored tumor necrosis factor mediates the protective effects of tumor necrosis factor signaling in experimental stroke, and therapeutic strategies specifically targeting soluble tumor necrosis factor could be beneficial in clinical stroke therapy.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
7001 a Clausen, Bettina H4 aut
7001 a Degn, Matilda4 aut
7001 a Thyssen, Stine4 aut
7001 a Kristensen, Lotte K4 aut
7001 a Svensson, Martinau Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Neuroinflammation,Forskargrupper vid Lunds universitet,Department of Experimental Medical Science,Faculty of Medicine,Lund University Research Groups4 aut0 (Swepub:lu)med-ms17
7001 a Ditzel, Nicholas4 aut
7001 a Finsen, Bente4 aut
7001 a Deierborg, Tomasu Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Neuroinflammation,Forskargrupper vid Lunds universitet,Department of Experimental Medical Science,Faculty of Medicine,Lund University Research Groups4 aut0 (Swepub:lu)expb-tol
7001 a Brambilla, Roberta4 aut
7001 a Lambertsen, Kate L4 aut
7102 a Institutionen för experimentell medicinsk vetenskapb Medicinska fakulteten4 org
7730 t Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolismx 1559-7016
8564 u http://www.ncbi.nlm.nih.gov/pubmed/26661199?dopt=Abstracty FULLTEXT
8564 u http://dx.doi.org/10.1177/0271678X15610339y FULLTEXT
8564 8u https://lup.lub.lu.se/record/8505027
8564 8u https://doi.org/10.1177/0271678X15610339

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