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Sökning: WFRF:(Toure Ousmane) > (2013) > Human Candidate Pol...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04723naa a2200613 4500 | |
| 001 | oai:DiVA.org:su-96099 | |
| 003 | SwePub | |
| 008 | 131111s2013 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-960992 URI |
| 024 | 7 | a https://doi.org/10.1371/journal.pone.00756752 DOI |
| 040 | a (SwePub)su | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Maiga, Bakaryu Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,University of Science, Technique and Technologies of Bamako (USTTB), Mali4 aut0 (Swepub:su)maba8346 |
| 245 | 1 0 | a Human Candidate Polymorphisms in Sympatric Ethnic Groups Differing in Malaria Susceptibility in Mali |
| 264 | c 2013-10-02 | |
| 264 | 1 | b Public Library of Science (PLoS),c 2013 |
| 338 | a print2 rdacarrier | |
| 500 | a AuthorCount:15;Funding agencies:Wellcome Trust WT077383/Z/05/Z, 090770/Z/09/Z, 075491/Z/04, 090532/Z/09/Z, 098051; Foundation of the National Institutes of Health, Bill & Melinda Gates' Grand Challenges in Global Health Initiative 566; Medical Research Council G0600718, G0600230; Fundacao para Ciencia e Tecnologia, Portugal Pest-OE/MAT/UI0006/2011 | |
| 520 | a Malaria still remains a major public health problem in Mali, although disease susceptibility varies between ethnic groups, particularly between the Fulani and Dogon. These two sympatric groups share similar socio-cultural factors and malaria transmission rates, but Fulani individuals tend to show significantly higher spleen enlargement scores, lower parasite prevalence, and seem less affected by the disease than their Dogon neighbours. We have used genetic polymorphisms from malaria-associated genes to investigate associations with various malaria metrics between the Fulanai and Dogon groups. Two cross sectional surveys (transmission season 2006, dry season 2007) were performed. Healthy volunteers from the both ethnic groups (n=939) were recruited in a rural setting. In each survey, clinical (spleen enlargement, axillary temperature, weight) and parasitological data (malaria parasite densities and species) were collected, as well as blood samples. One hundred and sixty six SNPs were genotyped and 5 immunoassays (AMA1, CSP, MSP1, MSP2, total IgE) were performed on the DNA and serum samples respectively. The data confirm the reduced malaria susceptibility in the Fulani, with a higher level of the protective O-blood group, and increased circulating antibody levels to several malaria antigens (p<10(-15)). We identified SNP allele frequency differences between the 2 ethnic groups in CD36, IL4, RTN3 and ADCY9. Moreover, polymorphisms in FCER1A, RAD50, TNF, SLC22A4, and IL13 genes were correlated with antibody production (p-value<0.003). Further work is required to understand the mechanisms underpinning these genetic factors. | |
| 650 | 7 | a NATURVETENSKAPx Biologi0 (SwePub)1062 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Biological Sciences0 (SwePub)1062 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng |
| 653 | a Malaria | |
| 653 | a Malarial parasites | |
| 653 | a Ethnic epidemiology | |
| 653 | a Spleen | |
| 653 | a Variant genotypes | |
| 653 | a Mali | |
| 653 | a Parasitic diseases | |
| 653 | a Genetic polymorphism | |
| 700 | 1 | a Dolo, Amagana4 aut |
| 700 | 1 | a Toure, Ousmane4 aut |
| 700 | 1 | a Dara, Victor4 aut |
| 700 | 1 | a Tapily, Amadou4 aut |
| 700 | 1 | a Campino, Susana4 aut |
| 700 | 1 | a Sepulveda, Nuno4 aut |
| 700 | 1 | a Risley, Paul4 aut |
| 700 | 1 | a Silva, Nipula4 aut |
| 700 | 1 | a Corran, Patrick4 aut |
| 700 | 1 | a Rockett, Kirk A.4 aut |
| 700 | 1 | a Kwiatkowski, Dominic4 aut |
| 700 | 1 | a Clark, Taane G.4 aut |
| 700 | 1 | a Troye-Blomberg, Maritau Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut4 aut0 (Swepub:su)marita |
| 700 | 1 | a Doumbo, Ogobara K.4 aut |
| 710 | 2 | a Stockholms universitetb Institutionen för molekylär biovetenskap, Wenner-Grens institut4 org |
| 773 | 0 | t PLOS ONEd : Public Library of Science (PLoS)g 8:10q 8:10x 1932-6203 |
| 856 | 4 | u https://doi.org/10.1371/journal.pone.0075675y Fulltext |
| 856 | 4 | u https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0075675&type=printable |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-96099 |
| 856 | 4 8 | u https://doi.org/10.1371/journal.pone.0075675 |
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