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Sökning: WFRF:(Travaglini Leana) > (2013) > Between Peptides an...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003482naa a2200373 4500
001oai:lup.lub.lu.se:abe60f39-572c-4f59-8424-f750b85c55b7
003SwePub
008160401s2013 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/40624732 URI
0247 a https://doi.org/10.1021/jp405342v2 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Travaglini, Leana4 aut
2451 0a Between Peptides and Bile Acids: Self-Assembly of Phenylalanine Substituted Cholic Acids
264 c 2013-07-25
264 1b American Chemical Society (ACS),c 2013
520 a Biocompatible molecules that undergo self-assembly are of high importance in biological and medical applications of nanoscience. Peptides and bile acids are among the most investigated due to their ability to self-organize into many different, often stimuli-sensitive, supramolecular structures. With the aim of preparing molecules mixing the aggregation properties of bile acid and amino acid-based molecules, we report on the synthesis and self-association behavior of two diastereomers obtained by substituting a hydroxyl group of cholic acid with a L-phenylalanine residue. The obtained molecules are amphoteric, and we demonstrate that they show a pH-dependent self-assembly. Both molecules aggregate in globular micelles at high pH, whereas they form tubular superstructures under acid conditions. Unusual narrow nanotubes with outer and inner cross-section diameters of about 6 and 3 um are formed by the derivatives. The diasteroisomer with alpha orientation of the substituent forms in addition a wider tubule (17 nm cross-section diameter). The ability to pack in supramolecular tubules is explained in terms of a wedge-shaped bola-form structure of the derivatives. Parallel or antiparallel face-to-face dimers are hypothesized as fundamental building blocks for the formation of the narrow and wide nanotubes, respectively.
650 7a NATURVETENSKAPx Kemix Fysikalisk kemi0 (SwePub)104022 hsv//swe
650 7a NATURAL SCIENCESx Chemical Sciencesx Physical Chemistry0 (SwePub)104022 hsv//eng
7001 a D'Annibale, Andrea4 aut
7001 a di Gregorio, Maria Chiara4 aut
7001 a Schillén, Karinu Lund University,Lunds universitet,Fysikalisk kemi,Enheten för fysikalisk och teoretisk kemi,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Physical Chemistry,Physical and theoretical chemistry,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH4 aut0 (Swepub:lu)fk1-ksc
7001 a Olsson, Ulfu Lund University,Lunds universitet,Fysikalisk kemi,Enheten för fysikalisk och teoretisk kemi,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Physical Chemistry,Physical and theoretical chemistry,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH4 aut0 (Swepub:lu)fk1-uol
7001 a Sennato, Simona4 aut
7001 a Pavel, Nicolae V.4 aut
7001 a Galantini, Luciano4 aut
7102 a Fysikalisk kemib Enheten för fysikalisk och teoretisk kemi4 org
7730 t The Journal of Physical Chemistry Part Bd : American Chemical Society (ACS)g 117:31, s. 9248-9257q 117:31<9248-9257x 1520-5207x 1520-6106
8564 u http://dx.doi.org/10.1021/jp405342vy FULLTEXT
8564 8u https://lup.lub.lu.se/record/4062473
8564 8u https://doi.org/10.1021/jp405342v

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