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Identification of O...
Identification of Objective Morphometric Markers of Xerostomia in the Oral Mucosa Epithelium with In Vivo Confocal Microscopy
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- Fostad, Ida G. (författare)
- University of Oslo, Norway; Norwegian Dry Eye Clin, Norway
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- Eidet, Jon R. (författare)
- Norwegian Dry Eye Clin, Norway; Oslo University Hospital, Norway
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- Lagali, Neil (författare)
- Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Ögonkliniken US
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- Dartt, Darlene A. (författare)
- Harvard Medical Sch, MA 02114 USA
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- Raeder, Sten (författare)
- Norwegian Dry Eye Clin, Norway
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- Messelt, Edvard B. (författare)
- University of Oslo, Norway
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- Utheim, Tor P. (författare)
- University of Oslo, Norway; Norwegian Dry Eye Clin, Norway; Oslo University Hospital, Norway; Vestre Viken Hospital Trust, Norway
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(creator_code:org_t)
- CAMBRIDGE UNIV PRESS, 2017
- 2017
- Engelska.
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Ingår i: Microscopy and Microanalysis. - : CAMBRIDGE UNIV PRESS. - 1431-9276 .- 1435-8115. ; 23:1, s. 88-96
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The purpose of this work was to determine whether the morphology of the oral mucosa epithelium (OME) of patients with xerostomia differ from patients without xerostomia. In total, 34 patients with dry eye disease (DED) with or without xerostomia were examined at The Norwegian Dry Eye Disease Clinic with in vivo confocal microscopy of the lower lip. In addition, age- and gender-matched healthy controls (HC) were included. DED patients with xerostomia had a higher superficial to deep backscatter ratio compared with DED patients without xerostomia (p=0.002) and HC (p=0.001). Regression analysis demonstrated that this ratio was related to xerostomia independently of gender and age (pamp;lt;0.001). Sensitivity and specificity of detecting xerostomia were 0.78 and 0.85, respectively, when using a superficial to deep backscatter ratio cut-off value of 0.995 (p=0.004). The mean nucleus to cytosol backscatter ratio in the superficial OME was lower in patients with xerostomia than in those without xerostomia (p=0.034). In vivo confocal microscopy is a potential tool for evaluating the oral cavity and to assess changes in the OME associated with xerostomia, objectively and quantitatively. The cause of the increased backscatter in the superficial OME in xerostomia, however, remains to be elucidated.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Nyckelord
- xerostomia; dry mouth; in vivo confocal microscopy; oral mucosa epithelium
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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