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Sökning: WFRF:(Van Steen Kristel) > (2020-2022) > Robust genome-wide ...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005656naa a2200541 4500
001oai:DiVA.org:uu-419786
003SwePub
008200917s2020 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4197862 URI
0247 a https://doi.org/10.1038/s41598-020-68259-w2 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Li, Jiaruiu Univ Hosp Leuven, MIRC, Med Imaging Res Ctr, Leuven, Belgium.;Katholieke Univ Leuven, Dept Elect Engn, ESAT PSI, Leuven, Belgium.4 aut
2451 0a Robust genome-wide ancestry inference for heterogeneous datasets :b illustrated using the 1,000 genome project with 3D facial images
264 c 2020-07-16
264 1b Springer Science and Business Media LLC,c 2020
338 a electronic2 rdacarrier
520 a Estimates of individual-level genomic ancestry are routinely used in human genetics, and related fields. The analysis of population structure and genomic ancestry can yield insights in terms of modern and ancient populations, allowing us to address questions regarding admixture, and the numbers and identities of the parental source populations. Unrecognized population structure is also an important confounder to correct for in genome-wide association studies. However, it remains challenging to work with heterogeneous datasets from multiple studies collected by different laboratories with diverse genotyping and imputation protocols. This work presents a new approach and an accompanying open-source toolbox that facilitates a robust integrative analysis for population structure and genomic ancestry estimates for heterogeneous datasets. We show robustness against individual outliers and different protocols for the projection of new samples into a reference ancestry space, and the ability to reveal and adjust for population structure in a simulated case-control admixed population. Given that visually evident and easily recognizable patterns of human facial characteristics co-vary with genomic ancestry, and based on the integration of three different sources of genome data, we generate average 3D faces to illustrate genomic ancestry variations within the 1,000 Genome project and for eight ancient-DNA profiles, respectively.
650 7a NATURVETENSKAPx Biologix Genetik0 (SwePub)106092 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Genetics0 (SwePub)106092 hsv//eng
650 7a NATURVETENSKAPx Biologix Evolutionsbiologi0 (SwePub)106152 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Evolutionary Biology0 (SwePub)106152 hsv//eng
7001 a Zarzar, Tomas Gonzalezu Penn State Univ, Dept Anthropol, University Pk, PA 16802 USA.4 aut
7001 a White, Julie D.u Penn State Univ, Dept Anthropol, University Pk, PA 16802 USA.4 aut
7001 a Indencleef, Karlijneu Univ Hosp Leuven, MIRC, Med Imaging Res Ctr, Leuven, Belgium.;Katholieke Univ Leuven, Dept Neurosci, Expt Otorhinolaryngol, Leuven, Belgium.4 aut
7001 a Hoskens, Hanneu Univ Hosp Leuven, MIRC, Med Imaging Res Ctr, Leuven, Belgium.;Katholieke Univ Leuven, Dept Human Genet, Leuven, Belgium.4 aut
7001 a Matthews, Harryu Univ Hosp Leuven, MIRC, Med Imaging Res Ctr, Leuven, Belgium.;Katholieke Univ Leuven, Dept Human Genet, Leuven, Belgium.;Murdoch Childrens Res Inst, Melbourne, Vic, Australia.4 aut
7001 a Nauwelaers, Neleu Univ Hosp Leuven, MIRC, Med Imaging Res Ctr, Leuven, Belgium.;Katholieke Univ Leuven, Dept Elect Engn, ESAT PSI, Leuven, Belgium.4 aut
7001 a Zaidi, Arslanu Penn State Univ, Dept Anthropol, University Pk, PA 16802 USA.4 aut
7001 a Eller, Ryan J.u Indiana Univ Purdue Univ Indianapolis, Dept Biol, Indianapolis, IN USA.4 aut
7001 a Herrick, Noahu Indiana Univ Purdue Univ Indianapolis, Dept Biol, Indianapolis, IN USA.4 aut
7001 a Günther, Torstenu Uppsala universitet,Människans evolution4 aut0 (Swepub:uu)torgu835
7001 a Svensson, Emma,d 1979-u Uppsala universitet,Människans evolution4 aut0 (Swepub:uu)emsve020
7001 a Jakobsson, Mattiasu Uppsala universitet,Människans evolution4 aut0 (Swepub:uu)matja323
7001 a Walsh, Susanu Indiana Univ Purdue Univ Indianapolis, Dept Biol, Indianapolis, IN USA.4 aut
7001 a Van Steen, Kristelu Katholieke Univ Leuven, Dept Human Genet, Leuven, Belgium.;Univ Liege, Med Genom Res Unit, GIGA R, Liege, Belgium.;Walloon Excellence Life Sci & Biotechnol WELBIO, Liege, Belgium.4 aut
7001 a Shriver, Mark D.u Penn State Univ, Dept Anthropol, University Pk, PA 16802 USA.4 aut
7001 a Claes, Peteru Univ Hosp Leuven, MIRC, Med Imaging Res Ctr, Leuven, Belgium.;Katholieke Univ Leuven, Dept Elect Engn, ESAT PSI, Leuven, Belgium.;Katholieke Univ Leuven, Dept Human Genet, Leuven, Belgium.;Murdoch Childrens Res Inst, Melbourne, Vic, Australia.4 aut
7102 a Univ Hosp Leuven, MIRC, Med Imaging Res Ctr, Leuven, Belgium.;Katholieke Univ Leuven, Dept Elect Engn, ESAT PSI, Leuven, Belgium.b Penn State Univ, Dept Anthropol, University Pk, PA 16802 USA.4 org
7730 t Scientific Reportsd : Springer Science and Business Media LLCg 10:1q 10:1x 2045-2322
8564 u https://doi.org/10.1038/s41598-020-68259-wy Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1468286/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://www.nature.com/articles/s41598-020-68259-w.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-419786
8564 8u https://doi.org/10.1038/s41598-020-68259-w

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