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Proteomics Standards Initiative's ProForma 2.0 : Unifying the Encoding of Proteoforms and Peptidoforms br

LeDuc, Richard D. (author)
Northwestern Univ, Natl Resource Translat & Dev Prote, Evanston, IL 60611 USA.
Deutsch, Eric W. (author)
Inst Syst Biol, Seattle, WA 98109 USA.
Binz, Pierre-Alain (author)
Lausanne Univ Hosp, Clin Chem Serv, CH-1011 Lausanne, Switzerland.
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Fellers, Ryan T. (author)
Northwestern Univ, Natl Resource Translat & Dev Prote, Evanston, IL 60611 USA.
Cesnik, Anthony J. (author)
KTH,Science for Life Laboratory, SciLifeLab,Cellulär och klinisk proteomik,Stanford Univ, Dept Genet, Stanford, CA 94305 USA.;Chan Zuckerberg Biohub, San Francisco, CA 94158 USA.
Klein, Joshua A. (author)
Boston Univ, Program Bioinformat, Boston, MA 02215 USA.
Van den Bossche, Tim (author)
VIB UGent Ctr Med Biotechnol, B-9052 Ghent, Belgium.;Univ Ghent, Fac Med & Hlth Sci, Dept Biomol Med, B-9000 Ghent, Belgium.
Gabriels, Ralf (author)
VIB UGent Ctr Med Biotechnol, B-9052 Ghent, Belgium.;Univ Ghent, Fac Med & Hlth Sci, Dept Biomol Med, B-9000 Ghent, Belgium.
Yalavarthi, Arshika (author)
Northwestern Univ, Natl Resource Translat & Dev Prote, Evanston, IL 60611 USA.
Perez-Riverol, Yasset (author)
EMBL European Bioinformat Inst EMBL EBI, European Mol Biol Lab, Cambridge CB10 1SD, England.
Carver, Jeremy (author)
UCSD, Ctr Computat Mass Spectrometry, Dept Comp Sci & Engn, La Jolla, CA 92093 USA.;UCSD, Skaggs Sch Pharm & Pharmaceut Sci, La Jolla, CA 92093 USA.
Bittremieux, Wout (author)
UCSD, Skaggs Sch Pharm & Pharmaceut Sci, La Jolla, CA 92093 USA.;UCSD, Ctr Computat Mass Spectrometry, La Jolla, CA 92093 USA.
Kawano, Shin (author)
Toyama Univ Int Studies, Toyama, Toyama 9301292, Japan.;Res Org Informat & Syst, Joint Support Ctr Data Sci Res, Database Ctr Life Sci, Kashiwa, Chiba 2770871, Japan.
Pullman, Benjamin (author)
UCSD, Ctr Computat Mass Spectrometry, La Jolla, CA 92093 USA.;UCSD, Dept Comp Sci & Engn, La Jolla, CA 92093 USA.
Bandeira, Nuno (author)
UCSD, Ctr Computat Mass Spectrometry, Dept Comp Sci & Engn, La Jolla, CA 92093 USA.;UCSD, Skaggs Sch Pharm & Pharmaceut Sci, La Jolla, CA 92093 USA.
Kelleher, Neil L. (author)
Northwestern Univ, Natl Resource Translat & Dev Prote, Evanston, IL 60611 USA.
Thomas, Paul M. (author)
Northwestern Univ, Natl Resource Translat & Dev Prote, Evanston, IL 60611 USA.;AbbVie Inc, 1401 Sheridan Rd, N Chicago, IL 60064 USA.
Vizcaino, Juan Antonio (author)
EMBL European Bioinformat Inst EMBL EBI, European Mol Biol Lab, Cambridge CB10 1SD, England.
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Northwestern Univ, Natl Resource Translat & Dev Prote, Evanston, IL 60611 USA Inst Syst Biol, Seattle, WA 98109 USA. (creator_code:org_t)
2022-03-15
2022
English.
In: Journal of Proteome Research. - : American Chemical Society (ACS). - 1535-3893 .- 1535-3907. ; 21:4, s. 1189-1195
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • It is important for the proteomics community to have a standardizedmanner to represent all possible variations of a protein or peptide primary sequence,including natural, chemically induced, and artifactual modifications. The HumanProteome Organization Proteomics Standards Initiative in collaboration with severalmembers of the Consortium for Top-Down Proteomics (CTDP) has developed astandard notation called ProForma 2.0, which is a substantial extension of the originalProForma notation developed by the CTDP. ProForma 2.0 aims to unify therepresentation of proteoforms and peptidoforms. ProForma 2.0 supports use casesneeded for bottom-up and middle-/top-down proteomics approaches and allows theencoding of highly modified proteins and peptides using a human- and machine-readable string. ProForma 2.0 can be used to represent protein modifications in a specified or ambiguous location, designated bymass shifts, chemical formulas, or controlled vocabulary terms, including cross-links (natural and chemical) and atomic isotopes.Notational conventions are based on public controlled vocabularies and ontologies. The most up-to-date full specification documentand information about software implementations are available athttp://psidev.info/proforma.

Subject headings

NATURVETENSKAP  -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)

Keyword

ProForma
proteoform
peptidoform
top-down proteomics
file formats
data standards
mass spectrometry
FAIR

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art (subject category)

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