Sökning: WFRF:(Verdu Amoros J.) >
Pediatric Precursor...
Pediatric Precursor B-Cell Lymphoblastic Malignancies: From Extramedullary to Medullary Involvement
-
Kroeze, E. (författare)
-
Padilla, L. A. (författare)
-
Bakker, M. (författare)
-
visa fler...
-
Boer, J. M. (författare)
-
Hagleitner, M. M. (författare)
-
Burkhardt, B. (författare)
-
Mori, T. (författare)
-
Attarbaschi, A. (författare)
-
Verdu-Amoros, J. (författare)
-
Pillon, M. (författare)
-
Anderzhanova, L. (författare)
-
Kabickova, E. (författare)
-
Chiang, A. K. S. (författare)
-
Kebudi, R. (författare)
-
- Mellgren, Karin, 1962 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics
-
Lazic, J. (författare)
-
Jazbec, J. (författare)
-
Meijerink, J. P. P. (författare)
-
Beishuizen, A. (författare)
-
Loeffen, J. L. C. (författare)
-
European Intergrp, Childhood (författare)
-
Int Berlin Frankfurt, Munster (författare)
-
visa färre...
-
(creator_code:org_t)
- 2022-08-12
- 2022
- Engelska.
-
Ingår i: Cancers. - : MDPI AG. - 2072-6694. ; 14:16
- Relaterad länk:
-
https://gup.ub.gu.se...
-
visa fler...
-
https://doi.org/10.3...
-
visa färre...
Abstract
Ämnesord
Stäng
- Simple Summary B-cell lymphoblastic lymphoma (BCP-LBL) and B-cell acute lymphoblastic leukemia (BCP-ALL) are both malignancies of immature B-cells. However, BCP-ALL has been extensively studied and treatment protocols have changed over the last decades, whereas BCP-LBL is quite rare, and treatment has stayed roughly the same. In this retrospective study, we compare the clinical characteristics of a cohort of BCP-LBL patients to a cohort BCP-ALL patients. With the comparison of this unique large cohort of immature B-cell malignancies, we aim to contribute to elucidating whether BCP-LBL and BCP-ALL represent two diseases, or different representations of the same disease. Increasing the understanding of BCP-LBL in comparison to BCP-ALL is crucial for improving treatment and prognosis for BCP-LBL. B-cell lymphoblastic lymphoma (BCP-LBL) and B-cell acute lymphoblastic leukemia (BCP-ALL) are the malignant counterparts of immature B-cells. BCP-ALL is the most common hematological malignancy in childhood, while BCP-LBL accounts for only 1% of all hematological malignancies in children. Therefore, BCP-ALL has been well studied and treatment protocols have changed over the last decades, whereas treatment for BCP-LBL has stayed roughly the same. Clinical characteristics of 364 pediatric patients with precursor B-cell malignancies were studied, consisting of BCP-LBL (n = 210) and BCP-ALL (n = 154) patients. Our results indicate that based on the clinical presentation of disease, B-cell malignancies probably represent a spectrum ranging from complete isolated medullary disease to apparent complete extramedullary disease. Hepatosplenomegaly and peripheral blood involvement are the most important discriminators, as both seen in 80% and 95% of the BCP-ALL patients and in 2% of the BCP-LBL patients, respectively. In addition, we show that the overall survival rates in this cohort differ significantly between BCP-LBL and BCP-ALL patients aged 1-18 years (p = 0.0080), and that the outcome for infants (0-1 years) with BCP-LBL is significantly decreased compared to BCP-LBL patients of all other pediatric ages (p < 0.0001).
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- B-cell lymphoblastic lymphoma
- BCP-LBL
- B-cell acute lymphoblastic
- leukemia
- BCP-ALL
- non-Hodgkin lymphoma
- NHL
- disease spectrum
- leukemia
- children
- adolescents
- infants
- disease
- reduction
- lymphomas
- survival
- therapy
- trial
- Oncology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
-
Cancers
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- Av författaren/redakt...
-
Kroeze, E.
-
Padilla, L. A.
-
Bakker, M.
-
Boer, J. M.
-
Hagleitner, M. M ...
-
Burkhardt, B.
-
visa fler...
-
Mori, T.
-
Attarbaschi, A.
-
Verdu-Amoros, J.
-
Pillon, M.
-
Anderzhanova, L.
-
Kabickova, E.
-
Chiang, A. K. S.
-
Kebudi, R.
-
Mellgren, Karin, ...
-
Lazic, J.
-
Jazbec, J.
-
Meijerink, J. P. ...
-
Beishuizen, A.
-
Loeffen, J. L. C ...
-
European Intergr ...
-
Int Berlin Frank ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Cancer och onkol ...
- Artiklar i publikationen
-
Cancers
- Av lärosätet
-
Göteborgs universitet