Sökning: WFRF:(Williams Lynda M) > (2010-2014) > Genome-wide meta-an...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 13352naa a2203145 4500 | |
001 | oai:gup.ub.gu.se/161420 | |
003 | SwePub | |
008 | 240910s2012 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:umu-54103 | |
009 | oai:lup.lub.lu.se:9dc40d40-ba91-4bb7-af5b-36be7f6d81ae | |
009 | oai:DiVA.org:uu-176250 | |
024 | 7 | a https://gup.ub.gu.se/publication/1614202 URI |
024 | 7 | a https://doi.org/10.1038/ng.22492 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-541032 URI |
024 | 7 | a https://lup.lub.lu.se/record/28095202 URI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1762502 URI |
040 | a (SwePub)gud (SwePub)umud (SwePub)lud (SwePub)uu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Estrada, Karol4 aut |
245 | 1 0 | a Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. |
264 | c 2012-04-15 | |
264 | 1 | b Springer Science and Business Media LLC,c 2012 |
500 | a Published online 15 April 2012 | |
520 | a Bone mineral density (BMD) is the most widely used predictor of fracture risk. We performed the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 genome-wide association studies and 32,961 individuals of European and east Asian ancestry. We tested the top BMD-associated markers for replication in 50,933 independent subjects and for association with risk of low-trauma fracture in 31,016 individuals with a history of fracture (cases) and 102,444 controls. We identified 56 loci (32 new) associated with BMD at genome-wide significance (P < 5 × 10(-8)). Several of these factors cluster within the RANK-RANKL-OPG, mesenchymal stem cell differentiation, endochondral ossification and Wnt signaling pathways. However, we also discovered loci that were localized to genes not known to have a role in bone biology. Fourteen BMD-associated loci were also associated with fracture risk (P < 5 × 10(-4), Bonferroni corrected), of which six reached P < 5 × 10(-8), including at 18p11.21 (FAM210A), 7q21.3 (SLC25A13), 11q13.2 (LRP5), 4q22.1 (MEPE), 2p16.2 (SPTBN1) and 10q21.1 (DKK1). These findings shed light on the genetic architecture and pathophysiological mechanisms underlying BMD variation and fracture susceptibility. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Ortopedi0 (SwePub)302112 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Orthopaedics0 (SwePub)302112 hsv//eng |
653 | a Bone Density | |
653 | a genetics | |
653 | a Computational Biology | |
653 | a European Continental Ancestry Group | |
653 | a Extracellular Matrix Proteins | |
653 | a genetics | |
653 | a Female | |
653 | a Femur Neck | |
653 | a physiopathology | |
653 | a Fractures | |
653 | a Bone | |
653 | a genetics | |
653 | a Gene Expression Profiling | |
653 | a Genetic Predisposition to Disease | |
653 | a Genome-Wide Association Study | |
653 | a Genotype | |
653 | a Glycoproteins | |
653 | a genetics | |
653 | a Humans | |
653 | a Intercellular Signaling Peptides and Proteins | |
653 | a genetics | |
653 | a Low Density Lipoprotein Receptor-Related Protein-5 | |
653 | a genetics | |
653 | a Lumbar Vertebrae | |
653 | a physiopathology | |
653 | a Male | |
653 | a Mitochondrial Membrane Transport Proteins | |
653 | a genetics | |
653 | a Osteoporosis | |
653 | a genetics | |
653 | a Phosphoproteins | |
653 | a genetics | |
653 | a Polymorphism | |
653 | a Single Nucleotide | |
653 | a genetics | |
653 | a Quantitative Trait Loci | |
653 | a Risk Factors | |
653 | a Spectrin | |
653 | a genetics | |
653 | a genetik | |
653 | a Orthopaedics | |
700 | 1 | a Styrkarsdottir, Unnur4 aut |
700 | 1 | a Evangelou, Evangelos4 aut |
700 | 1 | a Hsu, Yi-Hsiang4 aut |
700 | 1 | a Duncan, Emma L4 aut |
700 | 1 | a Ntzani, Evangelia E4 aut |
700 | 1 | a Oei, Ling4 aut |
700 | 1 | a Albagha, Omar M E4 aut |
700 | 1 | a Amin, Najaf4 aut |
700 | 1 | a Kemp, John P4 aut |
700 | 1 | a Koller, Daniel L4 aut |
700 | 1 | a Li, Guo4 aut |
700 | 1 | a Liu, Ching-Ti4 aut |
700 | 1 | a Minster, Ryan L4 aut |
700 | 1 | a Moayyeri, Alireza4 aut |
700 | 1 | a Vandenput, Liesbeth,d 1974u Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research4 aut0 (Swepub:gu)xvanli |
700 | 1 | a Willner, Dana4 aut |
700 | 1 | a Xiao, Su-Mei4 aut |
700 | 1 | a Yerges-Armstrong, Laura M4 aut |
700 | 1 | a Zheng, Hou-Feng4 aut |
700 | 1 | a Alonso, Nerea4 aut |
700 | 1 | a Eriksson, Joelu Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research4 aut0 (Swepub:gu)xerjoe |
700 | 1 | a Kammerer, Candace M4 aut |
700 | 1 | a Kaptoge, Stephen K4 aut |
700 | 1 | a Leo, Paul J4 aut |
700 | 1 | a Thorleifsson, Gudmar4 aut |
700 | 1 | a Wilson, Scott G4 aut |
700 | 1 | a Wilson, James F4 aut |
700 | 1 | a Aalto, Ville4 aut |
700 | 1 | a Alen, Markku4 aut |
700 | 1 | a Aragaki, Aaron K4 aut |
700 | 1 | a Aspelund, Thor4 aut |
700 | 1 | a Center, Jacqueline R4 aut |
700 | 1 | a Dailiana, Zoe4 aut |
700 | 1 | a Duggan, David J4 aut |
700 | 1 | a Garcia, Melissa4 aut |
700 | 1 | a Garcia-Giralt, Natalia4 aut |
700 | 1 | a Giroux, Sylvie4 aut |
700 | 1 | a Hallmans, Göranu Umeå universitet,Näringsforskning4 aut0 (Swepub:umu)goha0001 |
700 | 1 | a Hocking, Lynne J4 aut |
700 | 1 | a Husted, Lise Bjerre4 aut |
700 | 1 | a Jameson, Karen A4 aut |
700 | 1 | a Khusainova, Rita4 aut |
700 | 1 | a Kim, Ghi Su4 aut |
700 | 1 | a Kooperberg, Charles4 aut |
700 | 1 | a Koromila, Theodora4 aut |
700 | 1 | a Kruk, Marcin4 aut |
700 | 1 | a Laaksonen, Marika4 aut |
700 | 1 | a Lacroix, Andrea Z4 aut |
700 | 1 | a Lee, Seung Hun4 aut |
700 | 1 | a Leung, Ping C4 aut |
700 | 1 | a Lewis, Joshua R4 aut |
700 | 1 | a Masi, Laura4 aut |
700 | 1 | a Mencej-Bedrac, Simona4 aut |
700 | 1 | a Nguyen, Tuan V4 aut |
700 | 1 | a Nogues, Xavier4 aut |
700 | 1 | a Patel, Millan S4 aut |
700 | 1 | a Prezelj, Janez4 aut |
700 | 1 | a Rose, Lynda M4 aut |
700 | 1 | a Scollen, Serena4 aut |
700 | 1 | a Siggeirsdottir, Kristin4 aut |
700 | 1 | a Smith, Albert V4 aut |
700 | 1 | a Svensson, Olleu Umeå universitet,Institutionen för kirurgisk och perioperativ vetenskap4 aut0 (Swepub:umu)olsv0001 |
700 | 1 | a Trompet, Stella4 aut |
700 | 1 | a Trummer, Olivia4 aut |
700 | 1 | a Mellström, Dan,d 1945u Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research4 aut0 (Swepub:gu)xmelda |
700 | 1 | a Woo, Jean4 aut |
700 | 1 | a Zhu, Kun4 aut |
700 | 1 | a Balcells, Susana4 aut |
700 | 1 | a Brandi, Maria Luisa4 aut |
700 | 1 | a Buckley, Brendan M4 aut |
700 | 1 | a Cheng, Sulin4 aut |
700 | 1 | a Christiansen, Claus4 aut |
700 | 1 | a Cooper, Cyrus4 aut |
700 | 1 | a Dedoussis, George4 aut |
700 | 1 | a Ford, Ian4 aut |
700 | 1 | a Frost, Morten4 aut |
700 | 1 | a Goltzman, David4 aut |
700 | 1 | a Gonzalez-Macias, Jesus4 aut |
700 | 1 | a Kähönen, Mika4 aut |
700 | 1 | a Karlsson, Magnusu Lund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups4 aut0 (Swepub:lu)orto-mka |
700 | 1 | a Khusnutdinova, Elza4 aut |
700 | 1 | a Koh, Jung-Min4 aut |
700 | 1 | a Kollia, Panagoula4 aut |
700 | 1 | a Langdahl, Bente Lomholt4 aut |
700 | 1 | a Leslie, William D4 aut |
700 | 1 | a Lips, Paul4 aut |
700 | 1 | a Ljunggren, Östenu Uppsala universitet,Institutionen för medicinska vetenskaper,Metabola bensjukdomar4 aut0 (Swepub:uu)osteljun |
700 | 1 | a Lorenc, Roman S4 aut |
700 | 1 | a Marc, Janja4 aut |
700 | 1 | a Mellström, Dan,d 1945u Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research4 aut0 (Swepub:gu)xmelda |
700 | 1 | a Obermayer-Pietsch, Barbara4 aut |
700 | 1 | a Olmos, José M4 aut |
700 | 1 | a Pettersson-Kymmer, Ulrikau Umeå universitet,Klinisk farmakologi4 aut0 (Swepub:umu)ulpe0007 |
700 | 1 | a Reid, David M4 aut |
700 | 1 | a Riancho, José A4 aut |
700 | 1 | a Ridker, Paul M4 aut |
700 | 1 | a Rousseau, François4 aut |
700 | 1 | a Slagboom, P Eline4 aut |
700 | 1 | a Tang, Nelson L S4 aut |
700 | 1 | a Urreizti, Roser4 aut |
700 | 1 | a Van Hul, Wim4 aut |
700 | 1 | a Viikari, Jorma4 aut |
700 | 1 | a Zarrabeitia, María T4 aut |
700 | 1 | a Aulchenko, Yurii S4 aut |
700 | 1 | a Castano-Betancourt, Martha4 aut |
700 | 1 | a Grundberg, Elin4 aut |
700 | 1 | a Herrera, Lizbeth4 aut |
700 | 1 | a Ingvarsson, Thorvaldur4 aut |
700 | 1 | a Johannsdottir, Hrefna4 aut |
700 | 1 | a Kwan, Tony4 aut |
700 | 1 | a Li, Rui4 aut |
700 | 1 | a Luben, Robert4 aut |
700 | 1 | a Medina-Gomez, Carolina4 aut |
700 | 1 | a Palsson, Stefan Th4 aut |
700 | 1 | a Reppe, Sjur4 aut |
700 | 1 | a Rotter, Jerome I4 aut |
700 | 1 | a Sigurdsson, Gunnar4 aut |
700 | 1 | a van Meurs, Joyce B J4 aut |
700 | 1 | a Verlaan, Dominique4 aut |
700 | 1 | a Williams, Frances M K4 aut |
700 | 1 | a Wood, Andrew R4 aut |
700 | 1 | a Zhou, Yanhua4 aut |
700 | 1 | a Gautvik, Kaare M4 aut |
700 | 1 | a Pastinen, Tomi4 aut |
700 | 1 | a Raychaudhuri, Soumya4 aut |
700 | 1 | a Cauley, Jane A4 aut |
700 | 1 | a Chasman, Daniel I4 aut |
700 | 1 | a Clark, Graeme R4 aut |
700 | 1 | a Cummings, Steven R4 aut |
700 | 1 | a Danoy, Patrick4 aut |
700 | 1 | a Dennison, Elaine M4 aut |
700 | 1 | a Eastell, Richard4 aut |
700 | 1 | a Eisman, John A4 aut |
700 | 1 | a Gudnason, Vilmundur4 aut |
700 | 1 | a Hofman, Albert4 aut |
700 | 1 | a Jackson, Rebecca D4 aut |
700 | 1 | a Jones, Graeme4 aut |
700 | 1 | a Jukema, J Wouter4 aut |
700 | 1 | a Khaw, Kay-Tee4 aut |
700 | 1 | a Lehtimäki, Terho4 aut |
700 | 1 | a Liu, Yongmei4 aut |
700 | 1 | a Lorentzon, Mattias,d 1970u Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research4 aut0 (Swepub:gu)xlomat |
700 | 1 | a McCloskey, Eugene4 aut |
700 | 1 | a Mitchell, Braxton D4 aut |
700 | 1 | a Nandakumar, Kannabiran4 aut |
700 | 1 | a Nicholson, Geoffrey C4 aut |
700 | 1 | a Oostra, Ben A4 aut |
700 | 1 | a Peacock, Munro4 aut |
700 | 1 | a Pols, Huibert A P4 aut |
700 | 1 | a Prince, Richard L4 aut |
700 | 1 | a Raitakari, Olli4 aut |
700 | 1 | a Reid, Ian R4 aut |
700 | 1 | a Robbins, John4 aut |
700 | 1 | a Sambrook, Philip N4 aut |
700 | 1 | a Sham, Pak Chung4 aut |
700 | 1 | a Shuldiner, Alan R4 aut |
700 | 1 | a Tylavsky, Frances A4 aut |
700 | 1 | a van Duijn, Cornelia M4 aut |
700 | 1 | a Wareham, Nick J4 aut |
700 | 1 | a Cupples, L Adrienne4 aut |
700 | 1 | a Econs, Michael J4 aut |
700 | 1 | a Evans, David M4 aut |
700 | 1 | a Harris, Tamara B4 aut |
700 | 1 | a Kung, Annie Wai Chee4 aut |
700 | 1 | a Psaty, Bruce M4 aut |
700 | 1 | a Reeve, Jonathan4 aut |
700 | 1 | a Spector, Timothy D4 aut |
700 | 1 | a Streeten, Elizabeth A4 aut |
700 | 1 | a Zillikens, M Carola4 aut |
700 | 1 | a Thorsteinsdottir, Unnur4 aut |
700 | 1 | a Ohlsson, Claes,d 1965u Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research4 aut0 (Swepub:gu)xohlcl |
700 | 1 | a Karasik, David4 aut |
700 | 1 | a Richards, J Brent4 aut |
700 | 1 | a Brown, Matthew A4 aut |
700 | 1 | a Stefansson, Kari4 aut |
700 | 1 | a Uitterlinden, Andre G4 aut |
700 | 1 | a Ralston, Stuart H4 aut |
700 | 1 | a Ioannidis, John P A4 aut |
700 | 1 | a Kiel, Douglas P4 aut |
700 | 1 | a Rivadeneira, Fernando4 aut |
710 | 2 | a Göteborgs universitetb Centre for Bone and Arthritis Research4 org |
773 | 0 | t Nature geneticsd : Springer Science and Business Media LLCg 44:5, s. 491-501q 44:5<491-501x 1546-1718x 1061-4036 |
856 | 4 | u https://www.pure.ed.ac.uk/ws/files/8324950/Genome_wide_meta_analysis_identifies_56_bone_mineral_density_loci_and_reveals_14_loci_associated_with_risk_of_fracture.pdf |
856 | 4 | u http://dx.doi.org/10.1038/ng.2249y FULLTEXT |
856 | 4 8 | u https://gup.ub.gu.se/publication/161420 |
856 | 4 8 | u https://doi.org/10.1038/ng.2249 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-54103 |
856 | 4 8 | u https://lup.lub.lu.se/record/2809520 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-176250 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
Kopiera och spara länken för att återkomma till aktuell vy